| 田代 幸寛（たしろ ゆきひろ） | データ更新日：2024.04.17 |
准教授 ／
農学研究院
生命機能科学部門
| 1. | 田代幸寛、大城麦人, 4-1. バイオによるこれからのモノづくり 環境分野に関連したバイオによるこれからのモノづくりについて, 日本生物工学会100年史, pp. 51-53, 2022.10. |
| 2. | Min Zhang, Yukihiro Tashiro, Natsumi Ishida, Kenji Sakai, Application of autothermal thermophilic aerobic digestion as a sustainable recycling process of organic liquid waste: Recent advances and prospects, Science of the Total Environment, doi.org/10.1016/j.scitotenv.2022.154187, 828, 154187, 2022.07. |
| 3. | 田代幸寛、酒井謙二, 複合微生物プロセスの積極的な設計と制御―複合微生物工学創成を目指す研究アプローチ―, 日本生物工学会誌, DOI: 10.34565/seibutsukogaku.99.12_627, 99巻, 第12号, pp. 627-630, 2021.12. |
| 4. | 酒井謙二、田代幸寛, 複合微生物工学の創成, 日本生物工学会誌, DOI: 10.34565/seibutsukogaku.99.12_616, 99巻, 第12号, pp. 616, 2021.12. |
| 5. | Ming Gao、田代幸寛、Qunhui Wang、酒井謙二、園元謙二, 酢酸とグルコースを用いたpH-stat流加培養による高効率アセトン－ブタノール－エタノール生産（生物工学論文賞紹介記事） , 日本生物工学会誌, 第96巻, 第2号, pp. 68, 2018.02. |
| 6. | 宮本浩邦、宮本久、田代幸寛、酒井謙二、児玉浩明, 好熱性微生物を活用した未利用バイオマス資源からの高機能性発酵製品の製造と学術的解明【生物工学技術賞受賞記事】, 日本生物工学会誌, 第96巻, 第2号, pp. 56-63, 2018.02. |
| 7. | 渡邉康太, 西英二, 田代 幸寛, 酒井 謙二, ヒト毛髪に付着する細菌の存在形態および群集構造の解析, 第69回生物工学会大会 (2017) トピック集, pp. 66-67, 2017.09. |
| 8. | 西英二, 田代 幸寛, 酒井 謙二, 犯罪捜査におけるDNA鑑定によるヒトの異同識別, 化学と生物, 第55巻, 第8号, pp. 559 – 565, 2017.07. |
| 9. | Mohamed Ali Abdel-Rahman、Yaotian Xiao、田代幸寛、Ying Wang、善藤威史、酒井謙二、園元謙二, 混合糖からのカタボライト抑制を回避した効率的なブタノール生産（生物工学論文賞紹介記事）, 日本生物工学会誌, 第95巻, 第2号, pp. 73, 2017.02. |
| 10. | 田代 幸寛, 酒井 謙二, 複合微生物系を用いたメタ発酵による有価物変換法の制御と体系化, 環境バイオテクノロジー学会誌, 第16巻, 第1号, pp. 11-15, 2016.09. |
| 11. | Pramod Poudel, Yukihiro Tashiro, Kenji Sakai, New application of Bacillus strains for optically pure L-lactic acid production General overview and future prospects, Bioscience, Biotechnology and Biochemistry, 10.1080/09168451.2015.1095069, 2016.04, [URL], Members of the genus Bacillus are considered to be both, among the best studied and most commonly used bacteria as well as the most still unexplored and the most wide-applicable potent bacteria because novel Bacillus strains are continuously being isolated and used in various areas. Production of optically pure L-lactic acid (L-LA), a feedstock for bioplastic synthesis, from renewable resources has recently attracted attention as a valuable application of Bacillus strains. L-LA fermentation by other producers, including lactic acid bacteria and Rhizopus strains (fungi) has already been addressed in several reviews. However, despite the advantages of L-LA fermentation by Bacillus strains, including its high growth rate, utilization of various carbon sources, tolerance to high temperature, and growth in simple nutritional conditions, it has not been reviewed. This review article discusses new findings on LA-producing Bacillus strains and compares them to other producers. The future prospects for LA-producing Bacillus strains are also discussed.. |
| 12. | 木原隆寛, 野口拓也, 田代 幸寛, 酒井 謙二, 園元 謙二, デザインドバイオマスを用いたバイオプロセス開発：カタボライト抑制を回避した高効率連続ブタノール生産系の構築, 第67回生物工学会大会 (2015) トピック集, pp. 41-42, 2015.09. |
| 13. | 田代 幸寛, 淺田実, 砂掛愛, 酒井 謙二, 火山灰（桜島）における高度好熱細菌の生態分布と新規分離, 第67回生物工学会大会 (2015) トピック集, pp. 5-6, 2015.09. |
| 14. | 田代幸寛, バイオ燃料生産におけるデザインドバイオマスの創生と高速高効率化に関する新生物化学工学研究 , 生物工学, 第93巻, 第3号, pp. 130-138, 第37回生物工学奨励賞（照井賞）受賞論文, 2015.03. |
| 15. | 野口拓也, 田代 幸寛, 吉田剛士, Jin Zheng, 酒井 謙二, 園元 謙二, 混合糖からのカタボライト抑制を回避した効率的なブタノール生産（生物工学論文賞紹介記事, 日本生物工学会誌, 第93巻, 第2号, pp. 80, 2015.02. |
| 16. | Jin Zheng, Yukihiro Tashiro, Qunhui Wang, Kenji Sonomoto, Recent advances to improve fermentative butanol production Genetic engineering and fermentation technology, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2014.05.023, 第119巻, 第1号, pp.1–9, 2015.01, [URL], Butanol has recently attracted attention as an alternative biofuel because of its various advantages over other biofuels. Many researchers have focused on butanol fermentation with renewable and sustainable resources, especially lignocellulosic materials, which has provided significant progress in butanol fermentation. However, there are still some drawbacks in butanol fermentation in terms of low butanol concentration and productivity, high cost of feedstock and product inhibition, which makes butanol fermentation less competitive than the production of other biofuels. These hurdles are being resolved in several ways. Genetic engineering is now available for improving butanol yield and butanol ratio through overexpression, knock out/down, and insertion of genes encoding key enzymes in the metabolic pathway of butanol fermentation. In addition, there are also many strategies to improve fermentation technology, such as multi-stage continuous fermentation, continuous fermentation integrated with immobilization and cell recycling, and the inclusion of additional organic acids or electron carriers to change metabolic flux. This review focuses on the most recent advances in butanol fermentation especially from the perspectives of genetic engineering and fermentation technology.. |
| 17. | Ying Wang, Yukihiro Tashiro, Kenji Sonomoto, Fermentative production of lactic acid from renewable materials Recent achievements, prospects, and limits, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2014.06.003, 第119巻, 第1号, pp.10–18, 2015.01, [URL], The development and implementation of renewable materials for the production of versatile chemical resources have gained considerable attention recently, as this offers an alternative to the environmental problems caused by the petroleum industry and the limited supply of fossil resources. Therefore, the concept of utilizing biomass or wastes from agricultural and industrial residues to produce useful chemical products has been widely accepted. Lactic acid plays an important role due to its versatile application in the food, medical, and cosmetics industries and as a potential raw material for the manufacture of biodegradable plastics. Currently, the fermentative production of optically pure lactic acid has increased because of the prospects of environmental friendliness and cost-effectiveness. In order to produce lactic acid with high yield and optical purity, many studies focus on wild microorganisms and metabolically engineered strains. This article reviews the most recent advances in the biotechnological production of lactic acid mainly by lactic acid bacteria, and discusses the feasibility and potential of various processes.. |
| 18. | 田代 幸寛, 園元 謙二, 乳酸菌の新産業創成をめざした戦略的研究, 日本乳酸菌学会誌, 第25巻, 第3号, pp.155-165, 2014.11. |
| 19. | 田代 幸寛, 酒井 謙二, 複合微生物系を用いたメタ発酵による有価物生産プロセスの開発と制御, バイオサイエンスとインダストリー, 第72巻, 第6号, pp.486-487, 2014.11. |
| 20. | 田代 幸寛, バイオ燃料生産におけるデザインドバイオマスの創生と高速高効率化に関する新生物化学工学研究, 第66回生物工学会大会 (2014) トピック集, p. 11, 2014.09. |
| 21. | 吉田剛士, 田代 幸寛, 園元 謙二, Clostridium saccharoperbutylacetonicumによる乳酸とペントースからの高ブタノール生産（生物工学論文賞紹介記事）, 日本生物工学会誌, 第92巻, 第2号, pp. 69, 2014.02. |
| 22. | 野口拓也, 田代 幸寛, 園元 謙二, スマート発酵工学によるブタノール生産, バイオサイエンスとインダストリー, 第71巻, 第6号, pp. 530-532, 2013.11. |
| 23. | Mohamed Ali Sayed Mohamed Abdelrahman, Yukihiro Tashiro, Kenji Sonomoto, Recent advances in lactic acid production by microbial fermentation processes, Biotechnology Advances, 10.1016/j.biotechadv.2013.04.002, 第31巻, 第6巻, pp. 877–902, 2013.11, [URL], Fermentative production of optically pure lactic acid has roused interest among researchers in recent years due to its high potential for applications in a wide range of fields. More specifically, the sharp increase in manufacturing of biodegradable polylactic acid (PLA) materials, green alternatives to petroleum-derived plastics, has significantly increased the global interest in lactic acid production. However, higher production costs have hindered the large-scale application of PLA because of the high price of lactic acid. Therefore, reduction of lactic acid production cost through utilization of inexpensive substrates and improvement of lactic acid production and productivity has become an important goal. Various methods have been employed for enhanced lactic acid production, including several bioprocess techniques facilitated by wild-type and/or engineered microbes. In this review, we will discuss lactic acid producers with relation to their fermentation characteristics and metabolism. Inexpensive fermentative substrates, such as dairy products, food and agro-industrial wastes, glycerol, and algal biomass alternatives to costly pure sugars and food crops are introduced. The operational modes and fermentation methods that have been recently reported to improve lactic acid production in terms of concentrations, yields, and productivities are summarized and compared. High cell density fermentation through immobilization and cell-recycling techniques are also addressed. Finally, advances in recovery processes and concluding remarks on the future outlook of lactic acid production are presented.. |
| 24. | 村上奈緒, 大場真奈, 岩本真梨子, Abdel-Rahman Mohamed Ali, 田代 幸寛, 善藤 威史, 酒井 謙二, 園元 謙二, デザインドバイオマスを用いたバイオプロセス開発：乳酸菌によるグリセロールからのカーボンロスを伴わない光学活性乳酸とエタノール生産, 第65回生物工学会大会 (2013) トピック集, pp. 13-14, 2013.09. |
| 25. | Yukihiro Tashiro, Tsuyoshi Yoshida, Takuya Noguchi, Kenji Sonomoto, Recent advances and future prospects for increased butanol production by acetone-butanol-ethanol fermentation, Engineering in Life Sciences, 10.1002/elsc.201200128, 第13巻, 第5号, pp. 432–445 , 2013.09, [URL], Presently, several researchers are increasingly focusing on producing butanol as the next-generation fuel by acetone-butanol-ethanol (ABE) fermentation. Butanol has many superior characteristics compared to other biofuels, such as ethanol. However, its production by ABE fermentation faces the challenges of low productivity and yield because of product inhibition and heterofermentation, respectively, and thereby, high costs. Until date, molecular biological techniques and fermentation engineering methods have been applied for high butanol production. Although glucose remains the substrate of choice since traditional research, it is now necessary to substitute glucose derived from edible starch to other substrates from low-cost feedstock, such as agricultural residue. In addition, ABE-producing clostridia cannot directly produce butanol from lignocelluloses. Therefore, recent research is focusing on pretreatment and enzymatic saccharification of the complex molecules derived from agricultural residue for use as feedstock in butanol production. This article reviews traditional research, including the metabolism patterns and characteristics of ABE-producing clostridia. Furthermore, this article describes developments in ABE fermentation with respect to the establishment of highly efficient butanol production processes, such as batch, fed-batch, and continuous cultures, with the introduction of butanol removal, as well as butanol production from lignocellulosic biomasses or alternative substrates to sugars.. |
| 26. | 田代 幸寛, 環境中の細菌群集を知る新技術と課題, 日本生物工学会誌, 第91巻, 第4号, pp. 210, 2013.04. |
| 27. | Mohamed Ali Abdel-Rahman, Yukihiro Tashiro, Kenji Sonomoto, Lactic Acid Production from Lignocellulose-Derived Sugars using Lactic Acid Bacteria: Overview and Limits, Journal of Biotechnology, 第156巻, 第4号, pp. 286–301 (doi:10.1016/j.jbiotec.2011.06.017), 2011.12. |
| 28. | 田代幸寛, 複合微生物の有効活用と機能理解のために…, 日本生物工学会誌, 第89巻, 第6号, pp. 341, 2011.06. |
| 29. | 田代幸寛、吉田剛士、園元謙二, デザインドバイオマスによるバイオブタノール生産, 化学と工業, 第63巻, 第11号, pp. 894-896, 2010.11. |
| 30. | 田代幸寛、大城麦人、花田克浩、園元謙二, デザインドバイオマスによるバイオプロセスの開発：乳酸からのブタノール生産, 第62回生物工学会大会 (2010) トピック集, pp. 35-36, 2010.10. |
| 31. | 田代幸寛、園元謙二, 高速高効率バイオブタノール生産システムの開発, 日本生物工学会誌, 第87巻, 第10号, pp. 484-486, 2009.10. |
| 32. | 田代幸寛, 代謝工学とは？その発展と応用性, 日本生物工学会誌, 第87巻, 第5号, pp. 237, 2009.05. |
| 33. | 小林元太、田中重光、中園唯、田代幸寛、加藤富民雄、神田康三, 分子生物学的手法による有明海底泥中の細菌相解析, 佐賀大学有明海総合研究プロジェクト成果報告集, 第5巻, pp. 121-126, 2009.05. |
| 34. | 田代幸寛、進藤秀彰、林実希、馬場俊一、小林元太、園元謙二, 静止菌体を用いた酪酸からの新奇な高効率ブタノール生産システムの構築, 日本生物工学会誌, 第87巻, 第2号, pp. 79, 2009.02. |
| 35. | 大城麦人、田代幸寛、園元謙二, アセトン・ブタノール発酵における新バイオディーゼル燃料の生産, 廃棄物学会誌, 第19巻, 第6号, pp. 271-277, 2008.12. |
| 36. | 田代幸寛、大城麦人、園元謙二, 廃棄物からのバイオブタノールの製造と高効率生産システムの開発, 分離技術, 第38巻, 第4号, pp. 241-245, 2008.07. |
| 37. | 大石浩隆、中島幹夫、田代幸寛、小林元太、富田由紀子、松本浩一、大重賢治, ビブリオ・バルニフィカス感染症対策―基礎医学的アプローチ（第三報）―, 佐賀大学有明海総合研究プロジェクト成果報告集, 第4巻, pp. 137-142, 2008.05. |
| 38. | 小林元太、田代幸寛、加藤富民雄, 有明海由来の微生物に関する研究, 佐賀大学有明海総合研究プロジェクト成果報告集, 第2巻, pp. 99-106,, 2006.07. |
| 39. | 田代幸寛、光武奈緒子、小林元太、加藤富民雄, 有明海干潟泥中の細菌相解析とビブリオ・バルニフィカス感染性バクテリオファージの分離, 第3巻, pp. 127-134, 2007.05. |
| 40. | 小林元太、岡宏圭、田代幸寛、加藤富民雄、林信行, 有明海由来のキシロース資化性新奇乳酸菌に関する研究, 佐賀大学有明海総合研究プロジェクト成果報告集, 第3巻, pp. 121-126, 2007.05. |
| 41. | 田代幸寛, 微生物の能力を最大限に発揮させよう!, 日本生物工学会誌, 第86巻, 第2号, pp. 97, 2008.02. |
| 42. | 田代幸寛、光武奈緒子、小林元太、加藤富民雄、神田康三, 有明海における細菌相解析, 佐賀大学有明海総合研究プロジェクト成果報告集, 第4巻, pp. 113-120, 2008.05. |
| 43. | 小林元太、田代幸寛、光武奈緒子、加藤富民雄、神田康三, 有明海と伊勢湾・三河湾における細菌相の比較, 佐賀大学有明海総合研究プロジェクト成果報告集, 第4巻, pp. 105-112, 2008.05. |
| 44. | 加藤富民雄、中川良美、小林元太、田代幸寛、神田康三, 有明海に生息する乳酸菌の生産するII型制限酵素, 佐賀大学有明海総合研究プロジェクト成果報告集, 第4巻, pp. 99-104, 2008.05. |
| 45. | 田代幸寛、小林元太, アセトン・ブタノール発酵による未利用バイオマスの資源化, バイオサイエンスとインダストリー, 第61巻, 第8号, pp.28-31, 2003.08. |
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