Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
UMENO JUNJI Last modified date:2022.05.02

Assistant Professor / Department of Medicine and Clinical Science, Graduate School of Medical Sciences / Department of Gastroenterology / Kyushu University Hospital

1. Colitis associated with anticancer/molecular-targeted drug.
2. Profile Views of Early Colorectal Cancers during Barium Enema.
3. Nakanishi T, Nakamura Y, Umeno J, Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action., Pharmacology & Therapeutics, 10.1016/j.pharmthera.2021.107803, Vol.223, p.107803, 2021.01, Solute carrier organic anion transporter family member 2A1 (SLCO2A1, also known as PGT, OATP2A1, PHOAR2, or SLC21A2) is a plasma membrane transporter consisting of 12 transmembrane domains. It is ubiquitously expressed in tissues, and mediates the membrane transport of prostaglandins (PGs, mainly PGE2, PGF2α, PGD2) and thromboxanes (e.g., TxB2). SLCO2A1-mediated transport is electrogenic and is facilitated by an outwardly directed gradient of lactate. PGs imported by SLCO2A1 are rapidly oxidized by cytoplasmic 15-hydroxyprostaglandin dehydrogenase (15-PGDH, encoded by HPGD). Accumulated evidence suggests that SLCO2A1 plays critical roles in many physiological processes in mammals, and it is considered a potential pharmacological target for diabetic foot ulcer treatment, antipyresis, and non-hormonal contraception. Furthermore, whole-exome analyses suggest that recessive inheritance of SLCO2A1 mutations is associated with two refractory diseases, primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with SLCO2A1 (CEAS). Intriguingly, SLCO2A1 is also a key component of the Maxi-Cl channel, which regulates fluxes of inorganic and organic anions, including ATP. Further study of the bimodal function of SLCO2A1 as a transporter and ion channel is expected to throw new light on the complex pathology of human diseases. Here, we review and summarize recent information on the molecular functions of SLCO2A1, and we discuss its pathophysiological significance..
4. Clinical Practice and Usefulness of Small Bowel Radiography.
5. Diagnosis of Gastrointestinal Polyposis Syndromes.
6. Clinical features of chronic enteropathy associated with SLCO2A1 gene (CEAS).
7. IBD unclassified (IBDU)/Indeterminate colitis (IC).
8. Non-neoplastic Disease of the Small Intestine-Chronic Enteropathy Associated with the SLCO2A1 Gene (CEAS).
9. Gastrointestinal Manifestations in Systemic Lupus Erythematosus.
10. motohiro esaki, Umeno Junji, Takanari Kitazono, Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine., Clinical journal of gastroenterology, 10.1007/s12328-015-0559-x, Vol.8, No.2, pp.57-62, 2015.04, Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use. However, because of the term "nonspecific" in its nomenclature, some gastroenterologists have misinterpreted the disease as the condition with small intestinal ulcers caused by undetermined etiologies without considering clinical features. Such misinterpretation has led to the heterogeneity of clinicopathologic features of the disease, as well as to ambiguity regarding a possible genetic contribution. It thus seems necessary to recognize the clinical entity of the disease precisely to avoid misinterpretation. In this review, we describe the clinicopathologic features, differential diagnosis, and the possibility of a genetic contribution to the disease..
11. Umeno Junji, Motohiro Esaki, Takayuki Matsumoto, lansoprazole consumption is more common in Japanese patients with collagenous colitis., 2013.07.
12. Endoscopic Diagnosis of Nontumorous Lesions of the Small Intestine.