Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Yukihisa Takayama Last modified date:2020.06.11

Assistant Professor / Radiology / Kyushu University Hospital


Presentations
1. Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Yasuhiro Ushijima, Tomohiro Nakayama, Daisuke Kakihara, Yuichiro Kubo, Koichiro Morita, Keisuke Ishimatsu, Seiichiro Takao, Tomoharu Yoshizumi, Kenichi Kouhashi, Prediction of Liver Fibrosis Using T1ρ and T2 Relaxations, 105th annual meeting of Radiological Society of North America, 2019.12, Purpose: To investigate the diagnostic performance of liver fibrosis stage using T1ρ relaxation in comparison with T2 relaxation
Materials and Methods: Eighty-three patients (F/M = 29/54, mean age, 69.4 yrs) with liver tumor were scanned MRI including T1ρ and T2 maps before the surgery. Among 83 patients, 67 patients had a history of chronic liver disease. but other 16 patients did not. All patients were classified into five stages (F0, n=21; F1, n=12; F2, n=20; F3, n=6 and F4, n=24) referring to the pathological examination of surgically resected specimens of the liver. Averaged T1ρ and T2 values of the liver parenchyma of each patient were measured after drawing three regions of interest on both maps. The Spearman correlation coefficient was calculated between T1ρ and liver fibrosis stages, and between T2 value and liver fibrosis stages. The performances in diagnosing cirrhosis (F4 vs F0-3), advanced fibrosis (F3-4 vs F0-2), clinically significant fibrosis (F2-4 vs F0-1), and with or without fibrosis (F1-4 vs. F0) were evaluated using a receiver operating characteristic (ROC) analysis.
Results: Mean T1ρ values of five stages were as follow: F0, 51.2 ms; F1, 52.0 ms; F2, 52.5 ms; F3, 61.9 ms and F4, 62.8 ms, respectively. Mean T2 values of five stages were as follow; F0, 37.2 ms; F1, 37.0 ms; F2, 37.9 ms; F3, 39.9 ms and F4, 43.3 ms, respectively. The Spearman correlation coefficients of T1ρ and T2 values were 0.55 and 0.51, respectively (p<0.05). ROC analysis showed the area under the curves (AUCs) of T1ρ for diagnosing cirrhosis (F4), advanced fibrosis (F3 or greater), and significant fibrosis (F2 or greater), with fibrosis (F1 or greater) were 0.82, 0.86, 0.75 and 0.69, respectively (p<0.05). In addition, ROC analysis showed the AUCs of T2 for diagnosing cirrhosis, advanced fibrosis, and significant fibrosis, with fibrosis were 0.82, 0.80, 0.71 and 0.64, respectively (p<0.05). However, there were no significant differences in AUCs between T1ρ and T2 values.
Conclusion: T1ρ relaxation, as well as T2 relaxation, has potential as a biomarker to predict liver fibrosis stage.
CLINICAL RELEVANCE/APPLICATION
T1ρ and T2 relaxations may help clinicians for the non-invasive prediction of liver fibrosis stage in patients with chronic liver disease.
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2. Yukihisa Takayama, Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, 柿原 大輔, Yasuhiro Ushijima, Fujita Nobuhiro, Takashi Yoshiura, Hiroshi Honda, Abdominal Diffusion-Weighted Imaging at 3T; Optimization to Improve Image Quality and Diagnostic Performance, 98th Scientific Assembly and Annual Meeting of Radiological Society of North America 2012, 2012.11.
3. Yukihisa Takayama, Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, Fujita Nobuhiro, 柿原 大輔, Yasuhiro Ushijima, Takashi Yoshiura, Hiroshi Honda, Optimization of Diffusion-Weighted Imaging for the Liver MRI at 3T: Usefulness for the Detection of Hepatocellular Carcinoma, ISMRM 20th Annual Meeting & Exhibition, 2012.05.
4. Yasuhiro Ushijima, Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, 柿原 大輔, Yukihisa Takayama, Fujita Nobuhiro, Yuichiro Kubo, Seiji Naito, Hiroshi Honda, Efficacy of diffusion-weighted magnetic resonance imaging in detection of renal pelvic cancer, The 2nd Meeting of Radiology Congress of North East Asia (RCNEA), 2012.09.
5. Kousei Ishigami, Akihiro Nishie, Asayama Yoshiki, 柿原 大輔, Yasuhiro Ushijima, Yukihisa Takayama, Fujita Nobuhiro, Masafumi Nakamura, Tetsuhide Ito, Hiroshi Honda, Differential diagnosis of pancreatic epidermoid cyst without a solid component (residual splenic tissue) vs. mucinous cystic neoplasm, The 2012 Annual Meeting of the American Roentgen Ray Society, 2012.04.
6. Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, 柿原 大輔, Yasuhiro Ushijima, Yukihisa Takayama, Fujita Nobuhiro, Ken Shirabe, Hiroshi Honda, Clinicopathological significance of the peritumoral decreased uptake area of Gd-EOB-DTPA in hypervascular hepatocellular carcinoma: novel application of Gd-EOB-DTPA-enhanced MRI., ISMRM 20th Annual Meeting & Exhibition, 2012.05.
7. Yasuhiro Ushijima, Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, 柿原 大輔, Yukihisa Takayama, Fujita Nobuhiro, Kanehiro Hasuo, Hiroshi Honda, Peribiliary arterial plexus; normal anatomy and clinical significance for hepato-biliary-pancreatic system, 98th Scientific Assembly and Annual Meeting of Radiological Society of North America 2012, 2012.11.
8. Asayama Yoshiki, Akihiro Nishie, Kousei Ishigami, 柿原 大輔, Yasuhiro Ushijima, Yukihisa Takayama, Fujita Nobuhiro, Ken Shirabe, Shinichi Aishima, Yuichiro Kubo, Hiroshi Honda, Fatty change in poorly differentiated hepatocellular carcinoma: possible mechanism in relation to decreased arterial flow., 98th Scientific Assembly and Annual Meeting of Radiological Society of North America 2012, 2012.11.
9. Akihiro Nishie, Asayama Yoshiki, Kousei Ishigami, 柿原 大輔, Yasuhiro Ushijima, Yukihisa Takayama, Fujita Nobuhiro, Seiji Naito, Hiroshi Honda, Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT, 98th Scientific Assembly and Annual Meeting of Radiological Society of North America 2012, 2012.11.
10. Fujita Nobuhiro, Akihiro Nishie, Asayama Yoshiki, Yasuhiro Ushijima, Yukihisa Takayama, Yuichiro Kubo, Ken Shirabe, Hiroshi Honda, Tumor-associated Macrophages Possibly Promote Angiogenesis in Well-differentiated Hepatocellular Carcinoma, European Congress of Radiology 2013, 2013.03.