Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Hiromitsu Araki Last modified date:2022.05.11

Assistant Professor / Department of Business and Technology Management / Department of Business and Technology Management / Faculty of Economics


Papers
1. Dai Shimizu, Kenzui Taniue, Yusuke Matsui, Hiroshi Haeno, Hiromitsu Araki, Fumihito Miura, Mitsuko Fukunaga, Kenji Shiraishi, Yuji Miyamoto, Seiichi Tsukamoto, Aya Komine, Yuta Kobayashi, Akihiro Kitagawa, Yukihiro Yoshikawa, Kuniaki Sato, Tomoko Saito, Shuhei Ito, Takaaki Masuda, Atsushi Niida, Makoto Suzuki, Hideo Baba, Takashi Ito, Nobuyoshi Akimitsu, Yasuhiro Kodera, Koshi Mimori, Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin, CANCER GENE THERAPY, 10.1038/s41417-021-00401-w, 2021.11, The accurate and early diagnosis and classification of cancer origin from either tissue or liquid biopsy is crucial for selecting the appropriate treatment and reducing cancer-related mortality. Here, we established the CAncer Cell-of-Origin (CACO) methylation panel using the methylation data of the 28 types of cancer in The Cancer Genome Atlas (7950 patients and 707 normal controls) as well as healthy whole blood samples (95 subjects). We showed that the CACO methylation panel had high diagnostic potential with high sensitivity and specificity in the discovery (maximum AUC = 0.998) and validation (maximum AUC = 1.000) cohorts. Moreover, we confirmed that the CACO methylation panel could identify the cancer cell type of origin using the methylation profile from liquid as well as tissue biopsy, including primary, metastatic, and multiregional cancer samples and cancer of unknown primary, independent of the methylation analysis platform and specimen preparation method. Together, the CACO methylation panel can be a powerful tool for the classification and diagnosis of cancer..
2. Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono, Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle, SCIENCE ADVANCES, 10.1126/sciadv.abd7924, 7, 24, 2021.06.
3. Kentaro Inoue, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Transcriptome dynamics during cholesterol-induced transdifferentiation of human coronary artery smooth muscle cells: A Gene Ontology-centric clustering approach, Biochemistry and biophysics reports, 10.1016/j.bbrep.2021.101061, 27, 101061, 2021.09, Macrophage-like cells derived from vascular smooth muscle cells (SMCs) play critical roles in atherogenesis, and DNA hydroxymethylation was implicated in transdifferentiation. We examined transcriptomes and (hydroxy)methylomes of human coronary artery SMCs during cholesterol-induced transdifferentiation. A unique approach of exhaustive identification of differentially expressed genes followed by Gene Ontology-centric clustering facilitated deeper understanding of multifaceted modulations of genes involved in extracellular matrix organization, angiogenesis, cell migration, hypoxia response, and cholesterol biosynthesis. Intriguingly, type I interferon response was transiently activated, presumably forming an immuno-metabolic circuit with cholesterol metabolism. Neither global nor DEG-proximal changes were evident in (hydroxy)methylation. These results would not only provide a unique data resource for atherosclerosis research but present a potentially useful approach in transcriptome data interpretation..
4. Teruhiko Kawamura, Hiroyuki Tomari, Ichiro Onoyama, Hiromitsu Araki, Masafumi Yasunaga, Cui Lin, Keiko Kawamura, Natsuko Yokota, Sachiko Yoshida, Hiroshi Yagi, Kazuo Asanoma, Kenzo Sonoda, Katsuko Egashira, Takashi Ito, Kiyoko Kato, Identification of genes associated with endometrial cell ageing, Molecular Human Reproduction, 10.1093/molehr/gaaa078, 27, 2, 2020.12.
5. Yuhei Sangatsuda, Fumihito Miura, Hiromitsu Araki, Masahiro Mizoguchi, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yojiro Akagi, Takeo Amemiya, Yutaka Fujioka, Yasuhito Arai, Akihiko Yoshida, Tatsuhiro Shibata, Koji Yoshimoto, Koji Iihara & Takashi Ito, Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors, Scientific Reports, https://doi.org/10.1038/s41598-020-73116-x, 10, 16162, 2020.10.
6. Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif , Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki, Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity, NATURE IMMUNOLOGY, 10.1038/s41590-020-0700-y, 21, 8, 950-+, 2020.08.
7. Keisuke Yoshida, Toshio Maekawa, Nhung Hong Ly, Shin ichiro Fujita, Masafumi Muratani, Minami Ando, Yuki Katou, Hiromitsu Araki, Fumihito Miura, Katsuhiko Shirahige, Mariko Okada, Takashi Ito, Bruno Chatton, Shunsuke Ishii, ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet, Molecular Cell, 10.1016/j.molcel.2020.02.028, 78, 3, 445-458.e6, 2020.05.
8. Araki H, Miura F, Watanabe A, Morinaga C, Kitaoka F, Kitano Y, Sakai N, Shibata Y, Terada M, Goto S, Yamanaka S, Takahashi M, Ito T., Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation, STEM CELL REPORTS, 10.1016/j.stemcr.2019.08.014, 13, 4, 761-774, 2019.10.
9. Miura F, Shibata Y, Miura M, Sangatsuda Y, Hisano O, Araki H, Ito T., Highly efficient single-stranded DNA ligation technique improves low-input whole-genome bisulfite sequencing by post-bisulfite adaptor tagging, NUCLEIC ACIDS RESEARCH, 10.1093/nar/gkz435, 47, 15, 2019.09.
10. Alexander J. Trevarton, Michael B. Mann, Christoph Knapp, Hiromitsu Araki, Jonathan D. Wren, Steven Stones-Havas, Michael A. Black, Cristin G. Print, MelanomaDB
A web tool for integrative analysis of melanoma genomic information to identify disease-associated molecular pathways, Frontiers in Oncology, 10.3389/fonc.2013.00184, 3 JUL, 2013.12.
11. Yoshinori Tamada, Hiromitsu Araki, Seiya Imoto, Masao Nagasaki, Atsushi Doi, Yukiko Nakanishi, Yuki Tomiyasu, Kaori Yasuda, Ben Dunmore, Deborah Sanders, Sally Humphreys, Cristin Print, D. Stephen Charnock-Jones, Kousuke Tashiro, Satoru Kuhara, Satoru Miyano, Unraveling dynamic activities of autocrine pathways that control drug-response transcriptome networks, 14th Pacific Symposium on Biocomputing, PSB 2009 Pacific Symposium on Biocomputing 2009, PSB 2009, 251-263, 2009.12.
12. Hiromitsu Araki, Yoshinori Tamada, Seiya Imoto, Ben Dunmore, Deborah Sanders, Sally Humphrey, Masao Nagasaki, Atsushi Doi, Yukiko Nakanishi, Kaori Yasuda, Yuki Tomiyasu, Kousuke Tashiro, Cristin Print, D. Stephen Charnock-Jones, Satoru Kuhara, Satoru Miyano, Analysis of PPARα-dependent and PPARα-independent transcript regulation following fenofibrate treatment of human endothelial cells, Angiogenesis, 10.1007/s10456-009-9142-8, 12, 3, 221-229, 2009.09.
13. Seiya Imoto, Yoshinor Tamada, Hiromitsu Araki, Kaori Yasuda, Cristin G. Print, Stephen D. Charnock-Jones, Deborah Sanders, Christopher J. Savoie, Kousuke Tashiro, Satoru Kuhara, Satoru Miyano, Computational strategy for discovering druggable gene networks from genome-wide RNA expression profiles, 11th Pacific Symposium on Biocomputing 2006, PSB 2006 Proceedings of the Pacific Symposium on Biocomputing 2006, PSB 2006, 559-571, 2006.12.