Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Fusanori NISHIMURA Last modified date:2024.04.30

Professor / Division of Oral Rehabilitation / Department of Dental Science / Faculty of Dental Science

1. Takanori Shinjo, Fusanori Nishimura, The bidirectional association between diabetes and periodontitis, from basic to clinical., Japanese Dental Science Review, 10.1016/j.jdsr.2023, 2023.10.
2. David Polak, Terukazu Sanui, Fusanori Nishimura, Lior Shapira, Diabetes as a risk factor for periodontal disease—plausible mechanisms, Periodontology 2000, 10.1111/prd.12298, Vol.83, No.1, pp.46-58, 2020.06, The present narrative review examines the scientific evidence of the biological mechanisms that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding periodontitis and diabetes, in human, animals, and in vitro were screened for their relevance. Periodontal microbiome studies indicate a possible association between altered glucose metabolism in prediabetes and diabetes and changes in the periodontal microbiome. Coinciding with this, hyperglycemia enhances expression of pathogen receptors, which enhance host response to the dysbiotic microbiome. Hyperglycemia also promotes pro-inflammatory response independently or via the advanced glycation end product/receptor for advanced glycation end product pathway. These processes excite cellular tissue destruction functions, which further enhance pro-inflammatory cytokines expression and alteration in the RANKL/osteoprotegerin ratio, promoting formation and activation of osteoclasts. The evidence supports the role of several pathogenic mechanisms in the path of true causal comorbidity between poorly controlled diabetes and periodontitis. However, further research is needed to better understand these mechanisms and to explore other mechanisms..
3. Fusanori NISHIMURA, The influence of periodontal burdon on metabolic control of diabetes – Myth or relity? – from a nutritional perspective., Curr Oral Health Rep, 2017.04.
4. Fusanori NISHIMURA, The multi-center randomized controlled trial (RCT) published by the Journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems., J Evid based Dent Pract, 2014.09.