Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Akiko Mizokami Last modified date:2022.06.28

Associate Professor / Division of Oral Biological Sciences / Department of Dental Science / Faculty of Dental Science


Presentations
1. Akiko Mizokami, Takahito Otani, Takashi Kanematsu, Eijiro Jimi, Masato Hirata, Role of G-protein coupled receptor GPRC6A in regulating adipose tissue metabolism, 第63回歯科基礎医学会学術大会, 2021.10, GPRC6A, a member of family C of G protein-coupled receptors, has been proposed to be a master regulator of metabolic processes. It has been reported that global deletion of GPRC6A increases susceptibility to develop diet-induced obesity and metabolic related disorders. However, due to its broad tissue distribution and its ability to respond to a variety of hormonal and nutritional signals, the underlying cellular and molecular mechanisms of the metabolic disorders are still unclear. We previously reported that long-term oral administration of osteocalcin, one of the GPRC6A ligands, markedly reduced adipocyte size and improved glucose tolerance in wild type mice. Thus, we generated adipocyte-specific GPRC6A knockout mice (adG6AKO) and found that these animals manifested increased adipose tissue weight, adipocyte hypertrophy, and adipose tissue inflammation under obesogenic environment. These effects were associated with reduced lipolytic activity due to down-regulation of lipolytic enzymes in adipose tissue of adG6AKO mice. Our results suggest that the constitutive activation of GPRC6A signaling in adipocytes plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders..
2. Kawakubo-Yasukochi T, Kondo A, Mizokami A, Hirata M, The effect of maternal uncarboxylated osteocalcin on the metabolic properties of next generation, The 11th DOHaD World Congress, 2019.10.
3. Akiko Mizokami, Satoru Mukai, Takahito Otani, Hiroshi Takeuchi, Eijiro Jimi, and Masato Hirata, Adipocyte-specific GPRC6A ablation induces diet-induced obesity by inhibiting lipolysis., 2019 International Congress on Obesity and Metabolic Syndrome & Asia-Oceania Conference on Obesity (ICOMES & AOCO 2019), 2019.08.
4. Akiko Mizokami, Masato Hirata, Glucagon-Like Peptide-1 Receptor Signaling Is Required for an Osteocalcin-Mediated Improvement of Glucose Tolerance, American Diabetes Association’s 79th Scientific Sessions, 2019.06.
5. Akiko Mizokami, Satoru Mukai, Miho Matsuda, Hiroshi Takeuchi, Tomoyo Yasukochi, Eijiro Jimi, Masato Hirata, GPRC6A signaling and adiposity, 第60回歯科基礎医学会学術大会 , 2018.09.
6. Masato Hirata, Takahito Otani, Akiko Mizokami, Norio Kitagawa, Eijiro Jimi, Tetsuichiro Inai, Programmed necrosis of adipocyte induced by high-dose osteocalcin., 第91回日本薬理学会年会/第18回国際薬理学・臨床薬理学会議, 2018.07.
7. Mizokami A., Kawakubo-Yasukochi T., Hirata M., Sex differences in the regulation of energy metabolism by osteocalcin., International Congress on Obesity and Metabolic Syndrome, 2017.09.
8. Akiko Mizokami, Sex differences in the regulation of energy metabolism by osteocalcin., Gender Summit 10 Asia-Pacific, 2017.05.
9. Akihiko Kondo, Tomoyo Kawakubo-Yasukochioyo Kawakubo-Yasukochioyo Ka, Akiko Mizokami, Hiroshi Takeuchi, Masato Hirata, The role of uncarboxylated osteocalcin in prevention of early atherosclerosis, The 9th Korea-Japan Conference on Cellular Signaling for Young Scientists, 2016.07.
10. Sakura Chishaki, Akiko Mizokami, Masato Hirata, Sex difference in the effects of uncarboxylated osteocalcin on glucose homeostasis, The 9th Korea-Japan Conference on Cellular Signaling for Young Scientists, 2016.07.
11. Aya Nishikawa, Jing Gao, Akiko Mizokami, Makiko Hirata, Masato Hirata, Involvement of Phospholipase C-related but Catalytically Inactive Protein, PRIP in the Regulation of Insulin Signaling, The 9th Korea-Japan Conference on Cellular Signaling for Young Scientists, 2016.07.
12. Yoshikazu Hayashi, Tomoyo Kawakubo-Yasukochi, Akiko Mizokami, Seiji Nakamura, Masato Hirata, Uncarboxylated osteocalcin prevents cancer progression, The 9th Korea-Japan Conference on Cellular Signaling for Young Scientists, 2016.07.
13. Akiko Mizokami, Sex difference in osteocalcin action, Symposium for diversity initiatives and gendered innovations, 2016.03.
14. Akiko Mizokami, Yu Yasutake, Sakura Chishaki, Tomoyo Kawakubo-Yasukochi, Hiroshi Takeuchi, 平田 雅人, The effect of uncarboxylated osteocalcin on glucose utilization in mice., The 13th Asia Pacific Federation of Pharmacologists (APFP) Meeting, 2016.02.
15. Oral administration of osteocalcin improves glucose utilization by stimulating glucgon-like peptide-1 secretion.
16. Masato Hirata, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Takahito Otani, Yu Yasutake, BGM flow.

, The 55th International Symposium on Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues, 2014.09.
17. 溝上 顕子, 安武 雄, 竹内 弘, 高 靖, 平田 雅人, Osteocalcin induces release of glucagon-like peptide-1 and improves metabolic state in mice, The 8th Japan-Korea Conference on Cellular Signaling for Young Scientists, 2013.11.
18. 溝上 顕子, 安武 雄, 高 靖, 安河内 友世, 大谷 崇仁, 竹内 弘, 平田 雅人, Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice, Bones & Teeth Gordon Research Conference, 2014.01.