Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
SHONO YUJI Last modified date:2023.06.23

Assistant Professor / Emergency & Critical Care Center / Kyushu University Hospital

1. Shono Yuji, Mezuki Satomi, Akahoshi Tomohiko, Nishihara Masaaki, Kaku Noriyuki, Maki Jun, Tokuda Kentaro, Kitazono Takanari, Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 10.1177/03000605221119358, 50, 9, 2022.09.
2. Shono Y, Akahoshi T, Mezuki S, Momii K, Kaku N, Maki J, Tokuda K, Ago T, Kitazono T, Maehara Y, Clinical characteristics of type A acute aortic dissection with symptom of the central nervous system, American journal of emergency medicine, in press, 2017.06, Background and purpose
Accurate diagnosis of acute aortic dissection (AAD) is sometimes difficult because of accompanying central nervous system (CNS) symptoms. The purpose of this study was to investigate the clinical characteristics of Type A AAD (TAAAD) with CNS symptoms.
We retrospectively reviewed the medical records of 8403 patients ambulanced to our emergency and critical care center between April 2009 and May 2014.
We identified 59 TAAAD patients for the analysis (mean age, 67.3 ± 10.5 years; 37 (62.0%) male). Eleven patients (18.6%) presented CNS symptoms at the onset of TAAAD, and these patients complained less frequently of typical chest and back pain than those without CNS symptoms (p Conclusion
Because CNS symptom can mask chest and back pain caused by TAAAD, physicians should always consider the possibility of TAAAD in patients with CNS symptoms in emergency medicine settings..
3. Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M, Hirata K, Saji H, Tamaki N, Minematsu K, Gene expression associated with an enriched environment after transient focal ischemia, Brain research, 60-65, 2011.02.
4. Shono Y, Koga M, Toyoda K, Matsuoka H, Yokota C, Uehara T, Yamamoto H, Minematsu K, Medial medullary infarction identified by diffusion-weighted magnetic resonance imaging, Cerebrovascular disease, 30, 5, 519-524, 2010.12.
5. Shono Y, Kamouchi M, Kitazono T, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M, Change in intracellular pH causes the toxic Ca2+ entry via NCX1 in neuron- and glia-derived cells, Cellular and molecular neurobiology, 30, 3, 453-460, 2010.04.
6. Kiwamu Hatakeyama, Yuji Shono, Takuma Hashimoto, Taiki Sakamotoa, Masaaki Nishihara, Takeshi Iyonaga, Soichi Mizuguchi, Takafumi Sakamoto, Jun Maki, Tomohiko Akahoshi, Emphysematous pyelonephritis with ST elevation accompanied by reciprocal changes mimicking acute coronary syndrome, The Anerican Journal of Emergency Medicine, 2023.07, Patients with infectious diseases including sepsis can develop ST segment changes on an electrocardiogram (ECG) in the absence of coronary artery disease. However, ST elevation with “reciprocal ST segment depression”, which is recognized as a specific finding for ST-elevated myocardial infarction, is rare in such patients. Although a small number of cases have reported ST-segment elevation in gastritis, cholecystitis, and sepsis, regardless of coronary artery disease, none presented with reciprocal changes. Here, we describe a rare case of a patient with emphysematous pyelonephritis complicating septic shock who developed ST elevation accompanied by reciprocal changes with no coronary occlusion. Emergency physicians should consider the possibility of acute coronary syndrome mimicking, and choose non-invasive diagnostic procedures when investigating the causes of ECG abnormalities associated with critically ill patients..
7. Kenta Momii, Yuji Shono, Kanji Osaki, Yoshinori Nakanishi, Takeshi Iyonaga, Masaaki Nishihara, Tomohiko Akahoshi, Yasuharu Nakashima , Use of venovenous extracorporeal membrane oxygenation for perioperative management of acute respiratory distress syndrome caused by fat embolism syndrome: A case report and literature review, Medicine, 100, 8, e24929, 2021.02.
8. Sho Iwasaka, Yuji Shono, Kentaro Tokuda, Kosuke Nakashima, Yuzo Yamamoto, Jun Maki, Yoji Nagasaki, Nobuyuki Shimono, Tomohiko Akahoshi, Tomoaki Taguchi, Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 10.1016/j.jiac.2020.08.001, 26, 12, 1319-1323, 2020.12, The number of people infected with severe acute respiratory syndrome coronavirus 2 is increasing globally, and some patients have a fatal clinical course. In light of this situation, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. While clinical studies and basic research on a treatment for COVID-19 are ongoing around the world, no treatment has yet been proven to be effective. Several clinical studies have demonstrated the efficacy of chloroquine phosphate and nafamostat mesylate with COVID-19. Here, we report the case of a Japanese patient with COVID-19 with severe respiratory failure who improved following the administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate. Hence, hydroxychloroquine with nafamostat mesylate might be a treatment option for severe COVID-19..
9. Satomi Mezuki, Yuji Shono, Tomohiko Akahoshi, Kana Hisanaga, Hiroshi Saeki, Yuichiro Nakashima, Kenta Momii, Jun Maki, Kentaro Tokuda, Yoshihiko Maehara, Esophageal perforation due to blunt chest trauma: Difficult diagnosis because of coexisting severe disturbance of consciousness., The American journal of emergency medicine, 10.1016/j.ajem.2017.08.043, 35, 11, 1790.e3-1790.e5, 2017.11, Esophageal perforation due to blunt trauma is a rare clinical condition, and the diagnosis is often difficult because patients have few specific symptoms. Delayed diagnosis may result in a fatal clinical course due to mediastinitis and subsequent sepsis. In this article, we describe a 26-year-old man with esophageal perforation due to blunt chest trauma resulting from a motor vehicle accident. Because a severe disturbance of consciousness masked the patient's trauma-induced thoracic symptoms, we required 11h to diagnose the esophageal perforation. Therefore, the patient developed septic shock due to mediastinitis. However, his subsequent clinical course was good because of prompt combined therapy involving surgical repair and medical treatment after the diagnosis..
10. Enzan Nobuyuki, Hiasa Ken-ichi, Ichimura Kenzo, Nishihara Masaaki, Iyonaga Takeshi, Shono Yuji, Tohyama Takeshi, Funakoshi Kouta, Kitazono Takanari, Tsutsui Hiroyuki, Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 10.1093/ehjacc/zuac026, 11, 5, 389-396, 2022.06.
11. Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Yuji Shono, Shinichi Wada, Yoji Yoshikawa, Yuta Matsukuma, Takeshi Uchiumi, Dongchong Kang, Takanari Kitazono, Tetsuro Ago, Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman., Journal of the neurological sciences, 10.1016/j.jns.2020.116791, 412, 116791-116791, 2020.05.
12. Matsuo Ryu, Masahiro Kamouchi, Tetsuro Ago, Jun Hata, 生野 雄二, Junya Kuroda, Yoshinobu Wakisaka, Hiroshi Sugimori, Takanari Kitazono, Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry, Geriatric Gerontology International, 14, 4, 954-959, 2014.10.
13. Kenji Hirata, Yuji Kuge, Chiaki Yokota, Akina Harada, Koichi Kokame, Hiroyasu Inoue, Hidekazu Kawashima, Hiroko Hanzawa, Yuji Shono, Hideo Saji, Kazuo Minematsu, Nagara Tamaki, Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model., Neuroscience letters, 10.1016/j.neulet.2011.03.068, 495, 3, 210-5, 2011.05, Although an enriched environment enhances functional recovery after ischemic stroke, the mechanism underlying this effect remains unclear. We previously reported that brain derived neurotrophic factor (BDNF) gene expression decreased in rats housed in an enriched environment for 4 weeks compared to those housed in a standard cage for the same period. To further clarify the relationship between the decrease in BDNF and functional recovery, we investigated the effects of differential 2-week housing conditions on the mRNA of BDNF and protein levels of proBDNF and mature BDNF (matBDNF). After transient occlusion of the right middle cerebral artery of male Sprague-Dawley rats, we divided the rats into two groups: (1) an enriched group housed multiply in large cages equipped with toys, and (2) a standard group housed alone in small cages without toys. Behavioral tests before and after 2-week differential housing showed better neurological recovery in the enriched group than in the standard group. Synaptophysin immunostaining demonstrated that the density of synapses in the peri-infarct area was increased in the enriched group compared to the standard group, while infarct volumes were not significantly different. Real-time reverse transcription polymerase chain reaction, Western blotting and immunostaining all revealed no significant difference between the groups. The present results suggest that functional recovery cannot be ascribed to an increase in matBDNF or a decrease in proBDNF but rather to other underlying mechanisms..
14. Mayumi Mori, Haruko Yamamoto, Masatoshi Koga, Hideki Okatsu, Yuji Shono, Kazunori Toyoda, Kenji Fukuda, Koji Iihara, Naoaki Yamada, Kazuo Minematsu, Hyoid bone compression-induced repetitive occlusion and recanalization of the internal carotid artery in a patient with ipsilateral brain and retinal ischemia., Archives of neurology, 10.1001/archneurol.2010.371, 68, 2, 258-9, 2011.02.
15. Kuniyuki Nakamura, Masahiro Kamouchi, Takanari Kitazono, Junya Kuroda, Yuji Shono, Noriko Hagiwara, Tetsuro Ago, Hiroaki Ooboshi, Setsuro Ibayashi, Mitsuo Iida, Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes., Microvascular research, 10.1016/j.mvr.2008.12.001, 77, 3, 327-34, 2009.05, The aims of the present study were to investigate the mechanisms of Ca(2+) signaling caused by hydrogen peroxide in CNS pericytes. In cultured human brain microvascular pericytes, cytosolic Ca(2+) concentration was measured by means of fura-2 fluorescence. Reverse transcription and polymerase chain reaction was performed to examine the expression of mRNA. Knockdown of Na(+)/H(+) exchanger (NHE) was done by transfecting the cells with specific double-strand siRNAs for NHE. Externally applied hydrogen peroxide dose-dependently (100 microM-10 mM) increased cytosolic Ca(2+) in human CNS pericytes. Cytosolic Ca(2+) remained high after wash-out of hydrogen peroxide. However, the addition of dithiothreitol rapidly reversed cytosolic Ca(2+) to the resting level. The hydrogen peroxide-induced Ca(2+) increase was not inhibited by nicardipine, Gd(3+), La(3+), or omission of external Ca(2+). Neither thapsigargin nor carbonyl cyanide 4-trifluoromethoxyphenylhydrazone attenuated the hydrogen peroxide-induced Ca(2+) rise. Amiloride and its derivatives, benzamil and hexamethylene amiloride reversed the hydrogen peroxide-induced Ca(2+) increase. Human CNS pericytes expressed acid sensing ion channel (ASIC) 1a, Na(+)/Ca(2+) exchanger (NCX) 1, Na(+)/H(+) exchanger (NHE) 1, and NHE7. However, the removal of external Na(+), treatment with KB-R 7943 and mibefradil, or knockdown of NHE1 and NHE7 did not affect the hydrogen peroxide-induced Ca(2+) increase. Hydrogen peroxide releases Ca(2+) from intracellular Ca(2+) pool via an amiloride-sensitive protein, which is controlled by oxidation of thiol group in human CNS pericytes..