九州大学 研究者情報
論文一覧
山田 朋弘(やまだ ともひろ) データ更新日:2022.06.05

准教授 /  歯学研究院 歯学部門 口腔顎顔面病態学


原著論文
1. Safieh Al Bougha, Hiroyuki Nakano, Kousuke Yasuda, Kei Suzuki, Tomohiro Yamada, Ichiro Takahashi, Takaaki Ueno, Yoshihide Mori, Three-dimensional geometric morphometry of facial soft tissue changes after bilateral sagittal split ramus osteotomy, Journal of Craniofacial Surgery, 10.1097/SCS.0000000000008228, 33, 1, E92-E97, 2022.01, This study aimed to evaluate the performance of geometric morphometry (GM) to assess the changes in facial soft tissue after orthognathic surgery. Subjects were 27 patients (skeletal class III) who underwent bilateral sagittal split ramus osteotomy and 27 volunteers as a control group. Computed tomography images of each patient were obtained before surgery (T0) and 6 months after surgery (T1). Computed tomography images of 27 volunteers (skeletal class I) were also obtained as a control group. Using a three-dimensional (3D) modeling software, 3D models were created and exported to a 3D surface analyzing software for geometric morphometry and principal component (PC) analysis. Significant differences in facial soft tissue were found in the first and second of 15 PC. The first PC represented variation in the lower facial height, and the second PC represented variation in the anterior-posterior position of the chin. Comparing the pre-and post-operative images, they illustrated that lower facial height was decreased, and the chin and lower lip moved posteriorly. Geometric morphometry showed to be a successful tool to isolate surgeryrelated changes from interindividual morphological variations..
2. Ayano Ogura, Seiji Yamaguchi, Phuc Thi Minh Le, Kayoko Yamamoto, Michi Omori, Kazuya Inoue, Nahoko Kato-Kogoe, Yoichiro Nakajima, Hiroyuki Nakano, Takaaki Ueno, Tomohiro Yamada, Yoshihide Mori, The effect of simple heat treatment on apatite formation on grit-blasted/acid-etched dental Ti implants already in clinical use, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 10.1002/jbm.b.34915, 110, 2, 392-402, 2022.02, Grit-blasted/acid-etched titanium dental implants have a moderately roughened surface that is suitable for cell adhesion and exhibits faster osseointegration. However, the roughened surface does not always maintain stable fixation over a long period. In this study, a simple heat treatment at 600°C was performed on a commercially available dental Ti implant with grit-blasting/acid-etching, and its effect on mineralization capacity was assessed by examining apatite formation in a simulated body fluid (SBF). The as-purchased implant displayed a moderately roughened surface at the micrometer scale. Its surface was composed of titanium hydride accompanied by a small amount of alumina particles derived from the grit-blasting. Heat treatment transformed the titanium hydride into rutile without evidently changing the surface morphology. The immersion in SBF revealed that apatite formed on the heated implant at 7 days. Furthermore, apatite formed on the Ti rod surface within 1 day when the metal was subjected to acid and heat treatment without blasting. These indicate that apatite formation was conferred on the commercially available dental implant by simple heat treatment, although its induction period was slightly affected by alumina particles remaining on the implant surface. The heat-treated implant should achieve stronger and more stable bone bonding due to its apatite formation..
3. Chisato Sakuma, Hideto Imura, Tomohiro Yamada, Azumi Hirata, Yayoi Ikeda, Masaaki Ito, Nagato Natsume, Histological and Immunohistochemical Studies to Determine the Mechanism of Cleft Palate Induction after Palatal Fusion in Mice Exposed to TCDD., International journal of molecular sciences, 10.3390/ijms23042069, 23, 4, 2022.02, Rupture of the basement membrane in fused palate tissue can cause the palate to separate after fusion in mice, leading to the development of cleft palate. Here, we further elucidate the mechanism of palatal separation after palatal fusion in 8-10-week-old ICR female mice. On day 12 of gestation, 40 μg/kg of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), sufficient to cause cleft palate in 100% of mice, was dissolved in 0.4 mL of olive oil containing toluene and administered as a single dose via a gastric tube. Fetal palatine frontal sections were observed by H&E staining, and epithelial cell adhesion factors, apoptosis, and cell proliferation were observed from the anterior to posterior palate. TUNEL-positive cells and Ki67-positive cells were observed around the posterior palatal dissection area of the TCDD-treated group. Moreover, in fetal mice exposed to TCDD, some fetuses exhibited cleft palate dehiscence during fusion. The results suggest that palatal dehiscence may be caused by abnormal cell proliferation in epithelial tissues, decreased intercellular adhesion, and inhibition of mesenchymal cell proliferation. By elucidating the mechanism of cleavage after palatal fusion, this research can contribute to establishing methods for the prevention of cleft palate development..
4. Nakano H, Mizobuchi S, Sawai Y, Komori E, Suzuki K, Matsumura M, Sasai Y, Konda T, Ikeda S, Nakajima Y, Yamada T, Ueno T, Relationship between oral function and respiratory disturbance index in obstructive sleep apnea syndrome patients., Adv Dent & Oral Health, 10.19080, 14, 2, 555883, 2021.05.
5. Suzuki K, Nakano H, Yamada T, Mizobuchi S, Yasuda K, Albouga S, Inoue K, Matsumura M, Tajiri S, Mishima K, Mori Y, Ueno T, Establishment of a method for predicting a posed smile from a straight face, Journal of Hard Tissue Biology, 30, 3, 221-224, 2021.08.
6. Ogura A, Yamaguchi S, Le PTM, Yamamoto K, Omori M, Inoue K, Kato-Kogoe N, Nakajima Y, Nakano H, Ueno T, Yamada T, Mori Y., The effect of simple heat treatment on apatite formation on grit-blasted/acid-etched dental Ti implants already in clinical use., J Biomed Mater Res B Appl Biomater, 10.1002, 2021.07.
7. 住田知樹, 定成美来, 大膳力也, 千葉晃義, 山田朋弘, 森 悦秀, レーザープロセッシングによる純チタンを用いた顎骨再生療法, チタン, 68, 4, 316-319, 2020.10.
8. Yamada T, Sugiyama G, Mori Y, Masticatory muscle function affects the pathological conditions of jaw deformities., Japanese Dental Science Review, 2020.04.
9. Suzuki A, Sugiyama G, Kumamaru W, Yamada T, Mori Y, Regulation of NF-kB signalling through the PR55β-RelA interaction in osteoblasts, in vivo J, 2020.02.
10. Nakashima A, Yamada T, Sugiyama G, Mizunoya W, Nakano H, Yasuda K, Takahashi I, Mori Y, Masseter muscle properties differ between the left and right sides in mandibular Class III patients with asymmetry., Journal of Hard Tissue Biology, 2020.01.
11. 湯川綾美、山添淳一、和智(千北)さとみ、山田朋弘、和田尚久, 認知症の舌癌患者に対し,周術期口腔機能管理を通して経口摂取支援を行った一症例, 老年歯科医学, 34, 2, 136-142, 2019.11.
12. Yasuda K, Nakano H, Yamada T, Albougha S, Inoue K, Nakashima A, Kamata Y, Sugiyama G, Tajiri S, Sumida T, Mishima K, Mori Y, Identifying Differences Between a Straight Face and a Posed Smile Using the Homologous Modeling Technique and the Principal Component Analysis., The Journal of craniofacial surgery, 10.1097/SCS.0000000000005969, 30, 8, 2378-2380, 2019.11.
13. 今城育美、山田朋弘、大山順子、石井広太郎、森 悦秀, 顎口腔領域に初発症状を呈した悪性リンパ腫の臨床的検討, 日本口腔科学会雑誌, 2019.09.
14. Imajo I, Yamada T, Ishii K, Akahoshi T, Momii K, Kamizono K, Nakano H, Sumida T, Mori Y, Maxillofacial fractures caused by falls., Clinics in Surgery, 4, 2346, 2019.02.
15. Sakuma C, Imura H, Yamada T, Sugahara T, Hirata A, Ikeda Y, Natsume N, Cleft palate formation after palatal fusion occurs due to the rupture of epithelial basement membranes., Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 10.1016/j.jcms.2018.09.016, 46, 12, 2027-2031, 2018.09, [URL].
16. Yamada T, Sugiyama G, Higashimoto K, Nakashima A, Nakano H, Sumida T, Soejima H, Mori Y, Beckwith-Wiedemann syndrome with asymmetric mosaic of paternal disomy causing hemihyperplasia., Oral surgery, oral medicine, oral pathology and oral radiology, 10.1016/j.oooo.2018.07.053, 127, 3, E84-E88, 2018.08, [URL].
17. Azusa Nakashima, Tomohiro Yamada, Hiroyuki Nakano, Goro Sugiyama, Tomotaka Sugi, Y. U. Kamata, Tomoki Sumida, Yoshihide Mori, Jaw asymmetry may cause bad posture of the head and the spine—A preliminary study, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 10.1016/j.ajoms.2018.01.001, 30, 3, 242-246, 2018.05, Objective: Dental occlusion may relate to general conditions including posture, however, there is little evidence of jaw deformities and general posture. The objective of this study is to assess the relationship between skeletal jaw asymmetry and head/body posture. Methods: Forty-five mandibular asymmetry patients were included in this study. Lateral mandibular deviation, head inclination, and vertebrae deviation were studied before and after orthognathic surgery. Results: There was a correlation between mandibular deviation and head inclination, however, there were no correlation between vertebrae deviation and head inclination. On average, head inclination and vertebrae deviation were not changed after orthognathic surgery. But, for cases with a large deviation, they improved after surgery. Conclusions: Lateral mandibular deviation influences head and spine posture, in most cases reversibly..
18. Kana Ishibashi, Kotaro Ishii, Goro Sugiyama, Tomoki Sumida, Tsuyoshi Sugiura, Yu Kamata, Katsuhiro Seki, Takahiro Fujinaga, Wataru Kumamaru, Yosuke Kobayashi, Naomi Hiyake, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori, Deregulation of nicotinamide N-methyltransferase and gap junction protein alpha-1 causes metastasis in adenoid cystic carcinoma, Anticancer Research, 10.21873/anticanres.12207, 38, 1, 187-197, 2018.01, [URL], Background/Aim: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis. Materials and Methods: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells. Results: We examined the three cell lines. DNA microarray indicated significantly altered processes in ACCS-LN-GFP cells: particularly, the expression of nicotinamide N-methyltransferase (NNMT) was enhanced the most. NNMT is associated with tumorigenesis and is a potential tumor biomarker. Concomitantly, we found-significant down-regulation of gap junction protein alpha-1. We suggest that ACCS-LN-GFP cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1, leading to epithelial-mesenchymal transition and consequent AdCC metastasis. Conclusion: NNMT is a potential biomarker of AdCC..
19. Nakano H, Inoue K, Sumida T, Yamada T, Mori Y, Osteosynthesis Using the Uncalcined and Unsintered Hydroxyapatite / Poly-L-Lactic Acid System., Annals of maxillofacial surgery, 10.4103/ams.ams_192_17, 8, 1, 116-117, 2018.01, [URL].
20. Ishibashi K, Ishii K, Sugiyama G, Kamata YU, Suzuki A, Kumamaru W, Ohyama Y, Nakano H, Kiyoshima T, Sumida T, Yamada T, Mori Y, Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma., Cancer genomics & proteomics, 10.21873/cgp.20064, 15, 1, 53-60, 2018.01, [URL].
21. Kamata Y, Yamada T, Sumida T, Nakano H, Sugiyama G, Nakashima A, Mori Y., Pediatric treatment-resistant nonbacterial osteomyelitis of the mandible associated with SAPHO syndrome., Journal of Dental and Oral Health, 3, 7, 084, 2017.06.
22. Azusa Nakashima, Hiroyuki Nakano, Tomohiro Yamada, Kazuya Inoue, Goro Sugiyama, Wataru Kumamaru, Yasumichi Nakajima, Tomoki Sumida, Takeshi Yokoyama, Katsuaki Mishiama, Yoshihide Mori, The relationship between lateral displacement of the mandible and scoliosis, Oral and Maxillofacial Surgery, 10.1007/s10006-016-0607-9, 21, 1, 59-63, 2017.03, Objectives: Idiopathic scoliosis is an orthopaedic disease of childhood, with onset and progress occurring until adolescence. Here, the relationship between lateral displacement of the mandible and scoliosis was analysed quantitatively. Methods: Seventy-nine non-syndromic Japanese patients (18 men, 61 women), who were diagnosed with jaw deformities and underwent surgical orthognathic treatment at Kyushu University Hospital from January 2011 to August 2014, were enrolled. Their mean age at the time of radiography was 25.3 ± 8.7 years. Postero-anterior cephalometric radiographs and chest radiographs were examined. In postero-anterior cephalometric radiographs, a horizontal baseline (X-axis) was drawn as a straight line that intersects both the zygomatic bases, and a vertical line (Y-axis) was marked perpendicular to the X-axis, with an intersection at the anterior nasal spine (ANS). Point A was defined as the intersection of the X- and Y-axes, and line A was defined as the line connecting point A to the menton. The angle made by the X-axis and line A (i.e., lateral displacement of the mandible) was measured. We designated an absolute value even if the mandibular menton was located on the right or left side. In chest radiographs, Cobb’s method was used to measure scoliosis curves
the direction of the curve was designated similarly. Results: Nine (11.4%) individuals had a Cobb angle >
10°. There was a positive correlation between the Cobb angle and the degree of mandibular deviation (p <
 0.05). Conclusion: Lateral displacement of the mandible and scoliosis are related..
23. Sharma A, Paeng JY, Yamada T, Kwon TG, Simultaneous gap arthroplasty and intraoral distraction and secondary contouring surgery for unilateral temporomandibular joint ankylosis., Maxillofacial plastic and reconstructive surgery, 10.1186/s40902-016-0058-0, 38, 1, 12, 2016.12.
24. Yu Kamata, Tomoki Sumida, Ryuichi Murase, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori, Blockade of Androgen-induced Malignant Phenotypes by Flutamide Administration in Human Salivary Duct Carcinoma Cells, ANTICANCER RESEARCH, 10.21873/anticanres.11196, 36, 11, 6071-6075, 2016.11, Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5 alpha-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC..
25. Yasumichi Nakajima, Hiroyuki Nakano, Tomoki Sumida, Tomohiro Yamada, Kazuya Inoue, Goro Sugiyama, Katsuaki Mishima, Yoshihide Mori, High Le Fort I osteotomy for correction of mid-face deformity in Crouzon syndrome, CONGENITAL ANOMALIES, 10.1111/cga.12168, 56, 5, 240-242, 2016.09, An 18-year-old woman with mild Crouzon syndrome was referred with malocclusion and mandibular protrusion. Examination revealed Class III canine and molar relationships, hypoplastic maxilla, 1-mm overbite, and -2-mm overjet. Analysis showed 69 degrees sella-nasion-A, 73.6 degrees sella-nasion-B, and -4.6 degrees A point-nasion-B point angles. Polysomnography revealed respiratory disturbance and 6.3% oxygen desaturation indices of 5.4/h and 9.0/h. We performed double-jaw surgery using high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy for midfacial deformity correction. Twelve months post-surgery, her measures were 70.8 degrees, 72 degrees, -1.2 degrees, 3.0/h, and 6.1/h, respectively. Esthetics were satisfactory. High Le Fort I osteotomy is effective for midfacial deformity correction in patients with Crouzon syndrome..
26. Tomoki Sumida, Akiko Ishikawa, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori, Pierre-Yves Desprez, Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells, GENES TO CELLS, 10.1111/gtc.12389, 21, 8, 915-920, 2016.08, Inhibitors of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We previously determined that ID1 was highly expressed in aggressive salivary gland cancer (SGC) cells in culture. Here, we show that ID2 is also expressed in aggressive SGC cells. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. Moreover, ID2 knockdown almost completely suppresses invasion and the expression of matrix metalloproteinase 9. In conclusion, ID2 expression maintains an aggressive phenotype in SGC cells, and ID2 repression triggers a reduction in cell aggressiveness. ID2 therefore represents a potential therapeutic target during SGC progression. ID proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during SGC progression..
27. Tomoki Sumida, Akiko Ishikawa, Yu Kamata, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori, Estrogen.nhances Malignant Phenotypes in Human Salivary Adenoid Cystic Carcinoma Cells, ANTICANCER RESEARCH, 36, 6, 2793-2798, 2016.06, Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17 beta-estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy..
28. Tomohiro Yamada, Seiji Ohno, Naoya Kitamura, Eri Sasabe, Tetsuya Yamamoto, SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition, MEDICAL MOLECULAR MORPHOLOGY, 10.1007/s00795-014-0089-5, 48, 3, 129-137, 2015.09, The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell carcinoma (SCC) and controls were immunostained with SPARC. Clinical features and SPARC expression were evaluated. Furthermore, effects of SPARC knockdown and overexpression were examined in oral cancer and keratinocyte cell lines. Leukoplakia, carcinoma in situ, and early invasive SCC had more SPARC-positive cells than normal mucous epithelium. However, there were no significant differences between leukoplakia, carcinoma in situ, and early SCC, and there were no correlations between SPARC immunoreactivity and prognosis of invasive oral SCCs. Cell proliferation was down-regulated by SPARC siRNA, and enhanced by SPARC transformed keratinocytes. But SPARC overexpression did not enhance cell migration activity. SPARC is induced by dysplastic cells in the early stage of cancerization, and may improve survival capability, but is not involved in malignancy. SPARC may act to escape from elimination by cell competition..
29. Naruto Otawa, Tomoki Sumida, Hisashi Kitagaki, Kiyoyuki Sasaki, Shunsuke Fujibayashi, Mitsuru Takemoto, Takashi Nakamura, Tomohiro Yamada, Yoshihide Mori, Tomiharu Matsushita, Custom-made titanium devices as membranes for bone augmentation in implant treatment: Modeling accuracy of titanium products constructed with selective laser melting, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jcms.2015.05.006, 43, 7, 1289-1295, 2015.09, Objective: The purpose of this study was to verify the modeling accuracy of various products, and to produce custom-made devices for bone augmentation in individual patients requiring implantation.
Materials and methods: Two-(2D) and three-dimensional (3D) specimens and custom-made devices that were designed as membranes for guided bone regeneration (GBR) were produced using a computer-aided design (CAD) and rapid prototyping (RP) method. The CAD design was produced using a 3D printing machine and selective laser melting (SLM) with pure titanium (Ti) powder. The modeling accuracy was evaluated with regard to: the dimensional accuracy of the 2D and 3D specimens; the accuracy of pore structure of the 2D specimens; the accuracy of porosity of the 3D specimens; and the error between CAD design and the scanned real product by overlapped images.
Results: The accuracy of the 2D and 3D specimens indicated precise results in various parameters, which were tolerant in ISO 2768-1. The error of overlapped images between the CAD and scanned data indicated that accuracy was sufficient for GBR. In integrating area of all devices, the maximum and average error were 292 and 139 mu m, respectively.
Conclusions: High modeling accuracy can be achieved in various products using the CAD/RP-SLM method. These results suggest the possibility of clinical applications. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved..
30. Tomoki Sumida, Naruto Otawa, Yu Kamata, Tomohiro Yamada, Kenichiro Uchida, Hiroyuki Nakano, Hiroyuki Hamakawa, Tetsuya Yamamoto, Yoshiya Ueyama, Yoshihide Mori, A Clinical Investigation of Oral Sarcomas at Multi-institutions Over the Past 30 Years, ANTICANCER RESEARCH, 35, 8, 4551-4555, 2015.08, Background/Aim: Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. Patients and Methods: The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors. Results: Sarcoma accounted for 19 of 1,643 cases (1.16%) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyo sarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was > 50 mm in 8 patients, 7 of whom died. Tumor diameter was < 50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1% and 5-year survival rate was 36.8%. Conclusion: Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multi-institutional study..
31. Tomohiro Yamada, Naoya Kitamura, Eri Sasabe, Tetsuya Yamamoto, Plasmablastic lymphoma of the upper gingiva in an HIV-negative elderly patient, Oral and Maxillofacial Surgery Cases, 10.1016/j.omsc.2015.05.002, 1, 2, 19-24, 2015.06, Plasmablastic lymphoma (PBL) is a highly aggressive variant of diffuse large B-cell lymphoma and is usually treated by chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens. However, elderly patients tend to have difficulty with the chemotherapy. We successfully treated an HIV-negative elderly PBL patient with surgery alone. An 87-year-old Japanese man was referred to our hospital because of gingival swelling of the left maxilla. After several examinations, a multilobular 3-cm tumor of the left maxilla and lymph node swelling on the left side of the neck were revealed. The patient was HIV negative and human T-cell leukemia virus negative. He was diagnosed with PBL, or undifferentiated carcinoma/sarcoma, and we performed surgical therapy, radical neck dissection, and a partial maxillectomy. The surgical margin of the resected specimen was negative for tumor cells, and 6 of 27 lymph nodes contained tumor cells. Histologically, the tumor consisted of basophilic large cells with deviated nuclei. Together with the immunohistochemical findings, the final diagnosis was PBL. The patient and his family did not agree to chemotherapy. Nineteen months after surgery, he is fine and no signs of recurrence were observed. Surgery-only therapy may be a reasonable alternative for elderly PBL patients..
32. Naoya Kitamura, Riki Tomita, Mayo Yamamoto, Yasumasa Yoshizawa, Eri Sasabe, Tomohiro Yamada, Tetsuya Yamamoto, Complete remission of Merkel cell carcinoma on the upper lip treated with radiation monotherapy and a literature review of Japanese cases, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10.1186/s12157-015-0564-z, 13, 152, 2015.04, Merkel cell carcinoma is a rare and aggressive neuroendocrine-derived skin cancer arising most commonly on the sun-exposed head and neck skin of elderly and immunocompromised patients. Although a combination of wide excision and adjuvant radiotherapy is the optimal therapeutic approach for Merkel cell carcinoma, radiation monotherapy has recently been recommended for unresectable tumors. We report here a case of Merkel cell carcinoma treated with radiation monotherapy and reviewed Merkel cell carcinoma cases treated with radiotherapy alone in Japan. A 75-year-old man was referred for treatment of a tumor on the upper lip with a swollen submental lymph node. The histopathological diagnosis from biopsied material was Merkel cell carcinoma (T3N1bM0, stage IIIB). The submental lymph node was extirpated and radiation monotherapy was applied according to the 2014 National Comprehensive Cancer Network Guidelines because the Eastern Cooperative Oncology Group Performance Status of the patient was grade 3 and the patient and his family did not desire surgery. The primary site and bilateral upper neck regions were irradiated with 45 Gy followed by 20 Gy irradiation for the primary site alone. Three months after radiotherapy, the tumor seemed to have completely remitted. Approximately 1 year after radiotherapy, no evidence of local recurrence or late metastasis has been noted. Radiation monotherapy should be considered as a curative treatment for Merkel cell carcinoma, particularly in situations where extensive surgery is not favored..
33. Tomohiro Yamada, Mayu Takahashi, Manabu Matsumoto, Makoto Toi, Seiji Ohno, Naoya Kitamura, Eri Sasabe, Tetsuya Yamamoto, Mucinous Cystadenoma in the Upper Lip: Report of Two Cases, INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 10.1177/1066896913494796, 22, 4, 364-368, 2014.06, Mucinous cystadenoma of the salivary gland is a very rare disease, and only a few cases have been reported. We report here 2 cases of mucinous cystadenoma in the upper lip. The first case was a 57-year-old man and the second was a 42-year-old woman. The tumors were painless nodules with a smooth-surfaced mucosa, and surgical excisions were performed. Histologically, the tumors were surrounded by a fibrous capsule and were composed of multiple cysts lined with columnar epithelial cells. The tumor cells contain mucous substances that reacted with periodic acid-Schiff base and Alcian blue. Immunohistochemical staining revealed that the tumor cells expressed cytokeratin (AE1/3 and CK7), but their immunoreactivity with MIB-1 (Ki-67) was less than 3%. They had negative immunoreactivity for neuroectoderm markers, S-100 protein, and myoepithelial markers, p63, alpha-smooth muscle actin, and calponin, except for the accompanying myoepithelial-like cells. No recurrences were noted after surgery at 7 years and 1 year, respectively..
34. Tomohiro Yamada, Azumi Hirata, Eri Sasabe, Tomohide Yoshimura, Seiji Ohno, Naoya Kitamura, Tetsuya Yamamoto, TCDD disrupts posterior palatogenesis and causes cleft palate, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jcms.2013.01.024, 42, 1, 1-6, 2014.01, Dioxins (e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) cause cleft palate at a high rate. A post-fusional split may contribute to the pathogenesis, and tissue fragility may be a concern. The objective of this study was to investigate the effects of TCDD on the palatal epithelium, bone and muscle, which contribute to tissue integrity.
ICR mice (10-12 weeks old) were used. TCDD was administered on E12.5 at 40 mg/kg. Immunohistochemical staining-for AhR, ER-alpha, laminin, collagen IV, osteopontin, Runx2, MyoD, and desmin were performed. Furthermore, western blot analysis for osteopontin, Runx2, MyoD, and desmin were performed to evaluate protein expression in the palatal tissue.
Immunohistologically, there was little difference in the collagen IV and laminin localization in the palatal epithelium between control versus TCDD-treated mice. Runx2 and osteopontin immunoreactivity decreased in the TCDD-treated palatal bone, and MyoD and desmin decreased in the TCDD-treated palatal muscle. AhR and ER-alpha immunoreactivity were localized to the normal palatal bone, but ER-alpha was diminished in the TCDD-treated palate. On western blot analysis, Runx2, MyoD, and desmin were all downregulated in the TCDD-treated palate.
TCDD may suppress palatal osteogenesis and myogenesis via AhR, and cause cleft palates via a post-fusional split mechanism, in addition to a failure of palatal fusion. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved..
35. 山田 朋弘, 北村直也, 習慣性顎関節脱臼に対する外科的処置とその問題点 -Buckley Terry法と関節結節削除術の比較-, 日本口腔外科学会, 60, 1, 2-6, 2014.01.
36. Tomohiro Yamada, Tomohide Yoshimura, Naoya Kitamura, Eri Sasabe, Seiji Ohno, Tetsuya Yamamoto, Low-grade myofibroblastic sarcoma of the palate, INTERNATIONAL JOURNAL OF ORAL SCIENCE, 10.1038/ijos.2012.49, 4, 3, 170-173, 2012.09, Low-grade myofibroblastic sarcoma (LGMS) is a rare, malignant tumor with myofibroblastic differentiation. Despite it being classified as a distinct entity by the World Health Organization, a few cases were reported in the oral and maxillofacial region. Here, a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate. Based on the histological and immunohistochemical features, a diagnosis of LGMS was established. The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity. International Journal of Oral Science (2012) 4, 170-173; doi:10.1038/ijos.2012.49; published online 31 August 2012.
37. Tomohiro Yamada, Moritoshi Uchida, Kang Kwang-Lee, Naoya Kitamura, Tomohide Yoshimura, Eri Sasabe, Tetsuya Yamamoto, Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 10.1016/j.tripleo.2011.04.006, 113, 4, 464-471, 2012.04, Objective. The objective of this study was to analyze the relationship between the uptake of F-18-2-fluoro-2-deoxy-D-glucose (FDG) by positron emission tomography-computerized tomography (PET-CT) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (OSCC).
Study Design. Thirty-six patients with OSCC (tongue [n = 23], buccal mucosa [n = 7], and floor of the mouth [n = 6]) were assessed and underwent incisional biopsy and subsequently received FDG-PET-CT. Expressions of hypoxia-inducible factor 1 alpha (HIF-1 alpha), glucose transporter protein 1 (GLUT-1), hexokinase-II (HK-II), and glucose-6-phosphatase (G6Pase) were immunohistochemically quantified, and FDG uptake was evaluated by the maximum standardized uptake values (SUVmax) at the primary tumor site.
Results. FDG uptake was found to be significantly correlated with the T classification of OSCC but not with other clinicopathologic characteristics, such as the N classification, clinical type, and histologic grade of malignancy. In the early-stage (T1 and T2) tumor, FDG uptake was significantly associated with the expression levels of GLUT-1, HK II, and HIF-1 alpha, and the expression levels of GLUT-1 and HK-II significantly correlated with HIF-1 alpha expression levels. However, there were no correlations between the expression levels of these molecules and SUVmax in the late-stage (T3 and T4) tumor.
Conclusions. FDG uptake was significantly associated with the expression levels of glucose metabolism-related molecules, such as GLUT-1, HK II, and HIF-1 alpha, especially in early-stage tumors. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:464-471).
38. Katsuaki Mishima, Tomohiro Yamada, Tatsushi Matsumura, Norifumi Moritani, Analysis of lip motion using principal component analyses, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jcms.2010.04.006, 39, 4, 232-236, 2011.06, Objectives: The aim of this study was to quantitatively determine lip movement characteristics during the phonation of Japanese vowels.
Materials and methods: Lip motions of 14 normal individuals during the phonation of five Japanese vowels, /a/, /i/, /u/, /e/, and /o/ were analyzed. Using our developed motion analyzing system, range images were produced across the whole sequence during lip motions, and virtual grids were fitted onto surfaces. Principal component analyses were applied with three-dimensional coordinates of intersections for virtual grids regarded as variables.
Results and conclusion: The fourth and fifth principal component scores were shown to be parameters that control mouth opening and the retraction of the corners of the mouth, respectively. Discriminate analyses show it is possible to distinguish motion during the phonation of /u/ from that of other vowels. (C) 2010 European Association for Cranio-Maxillo-Facial Surgery..
39. Norifumi Moritani, Tomohiro Yamada, Koichi Mizobuchi, Mari Wakimoto, Yoko Ikeya, Tatsushi Matsumura, Katsuaki Mishima, Seiji Iida, Atypical Lipomatous Tumor of the Tongue: Report of a Case, ACTA MEDICA OKAYAMA, 10.18926/AMO/40134, 64, 4, 257-261, 2010.08, The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence..
40. Tomohiro Yamada, Katsuaki Mishima, Norifumi Moritani, Danilo Janune, Tatsushi Matsumura, Yoko Ikeya, Tetsuya Yamamoto, Nasolabial Morphologic Changes After a Le Fort I Osteotomy: A Three-Dimensional Anthropometric Study, JOURNAL OF CRANIOFACIAL SURGERY, 10.1097/SCS.0b013e3181e1e6ff, 21, 4, 1089-1095, 2010.07, After a Le Fort I osteotomy, nasal and labial changes are sometimes undesirable. The aim of this study was to perform a three-dimensional evaluation of the morphologic changes of the nose and lips after a Le Fort I osteotomy with a three-dimensional laser scanner.
Twelve female patients who underwent a Le Fort I osteotomy with bilateral sagittal split ramus osteotomy (mean age, 24.2 y) were selected. Three-dimensional facial morphology was measured immediately after surgery and 6 months after surgery with a three-dimensional laser scanner. Analysis of the three-dimensional data was performed with three-dimensional image analyzing software. The evaluation was performed by (1) linear and angular analyses of landmarks, (2) three-dimensional curvature, and (3) visual qualitative analysis using superimposing mapping images. The results were compared control with data taken from volunteers (mean age, 24.5 y).
Lateral expansion of nasal alae was commonly observed after surgery. The labial changes were mainly due to movements of the jawbone, and obvious flattening was not detected in this study. There was no relationship between the nasal changes and maxillary advancement.
The nasal morphologic changes after a Le Fort I osteotomy consist mainly of a widening of the nasal alae caused by the release of the muscle insertion and their retraction. This change was not influenced by the direction of maxillary movements..
41. Tomohiro Yamada, Katsuaki Mishima, Akiko Ota, Norifumi Moritani, Tatsushi Matsumura, Naoki Katase, Tetsuya Yamamoto, A case of ATLL (adult T-cell leukemia/lymphoma) mimicking odontogenic infection, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 10.1016/j.tripleo.2010.02.021, 109, 6, E51-E55, 2010.06, A case of adult T-cell leukemia/lymphoma (ATLL) in which cheek swelling was the initial symptom is presented. A 44-year-old man referred to our hospital with swelling in his right cheek, and a dental infection was suspected by a previous physician. Computerized tomographic scans and magnetic resonance imaging revealed tumorous lesions from the right alveolus of the maxilla to the anterior and posterior walls of the maxillary sinus. Anti-HTLV-1 antibodies were positive, and the level of sIL-2R was high; other laboratory test results were normal., based on immunohistochemical results on a specimen biopsy, the patient was diagnosed with a lymphoma-type ATLL. Immediately, the patient was treated in the department of hematologic medicine. After several courses of multiagent chemotherapy, 27 Gy radiation therapy was directed to the maxilla. However, remission was not achieved. Cord blood transplantation was subsequently performed, but his general condition gradually worsened until he died 7 months after his initial visit. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e51-e55).
42. Hideto Imura, Tomohiro Yamada, Katsuaki Mishima, Kumiko Fujiwara, Harumi Kawaki, Azumi Hirata, Norio Sogawa, Takaaki Ueno, Toshio Sugahara, Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion, CONGENITAL ANOMALIES, 10.1111/j.1741-4520.2010.00271.x, 50, 2, 77-84, 2010.06, Mouse embryos exposed to 2,3,7,8-tetrachloridedibenzo-p-dioxin (TCDD) develop cleft palates and hydronephrosis. Cleft palates occur after TCDD exposure due to contact and/or fusion failure. We investigated whether cleft palate can be induced by dissociation of the palatine process after fusion. Pregnant mice on gestational day (GD) 12 were randomly divided into two groups: one group was administered through gastric tubes one dose of olive oil (control group) and the other group was administered one dose of TCDD diluted with olive oil, both at a dose of 40 mu g/kg body weight. Embryos were removed by cesarean section from pregnant mice during the palatal formation stage (GD 13-18) and the palatal form was observed using a stereoscopic microscope. In TCDD-exposed embryos, palatal fusion was observed on GD 14, 15 and 16 and the incidence of cleft palate was 100% on GD 18. Fusion rates were 17.5 +/- 15.2% and 12.4 +/- 11.8% on GD 15 and 16, respectively. Some palates from the TCDD-exposed mouse embryos showed clearly developed cleft palate after fusion of the lateral palatine processes during palatal formation. A mass of cells, which were chiefly epithelial in the fused palates was observed in the TCDD-exposed mouse embryos. A decrease in E-cadherin expression was observed in this mass of cells, indicating its involvement in the development of cleft palate..
43. Harumi Kawaki, Satoshi Kubota, Akiko Suzuki, Noureddine Lazar, Tomohiro Yamada, Tatsushi Matsumura, Toshihiro Ohgawara, Takeyasu Maeda, Bernard Perbal, Karen M. Lyons, Masaharu Takigawa, Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Shown by a Comprehensive Analysis of the CCN Family Proteins in Cartilage, JOURNAL OF BONE AND MINERAL RESEARCH, 10.1359/JBMR.080615, 23, 11, 1751-1764, 2008.11, CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members. and its null mice display skeletal dysmorphisms. However, little is known concerning roles of the other CCN members in chondrocytes. Using both in vivo and in vitro approaches, We conducted a comparative analysis of CCN2-null and wildtype mice to study the roles of CCN2 and the other CCN proteins in cartilage development. Immunohistochemistry was used to evaluate the localization of CCN proteins and other chondrocyte-associated molecules in the two types of mice. Moreover, gene expression levels and the effects of exogenous CCN proteins oil chondrocyte proliferation, differentiation, and the expression of chondrocyte-associated genes in their primary chondrocytes were evaluated. Ccn3 was dramatically upregulated in CCN2-null cartilage and chondrocytes. This upregulation was associated with diminished cell proliferation and delayed differentiation. Consistent with the in vivo findings, CCN2 deletion entirely retarded chondrocyte terminal differentiation and decreased the expression of several chondrocyte-associated genes ill vitro. whereas CcO expression drastically increased. In contrast, the addition Of exogenous CCN2 promoted differentiation strongly and induced the expression of the associated genes. whereas decreasing, the CcO expression. These findings collectively indicate that CCN2 induces chondrocyte differentiation by regulating the expression of chondrocyte-associated genes but that these effects are counteracted by CCN3. The lack of CCN2 caused upregulation of CCN3 in CCN2-null mice, which resulted in the observed phenotypes, Such as the resultant delay of terminal differentiation. The involvement of the PTHrP-Ihh loop in the regulation of CCN3 expression is also suggested..
44. Katsuaki Mishima, Asuka Sugii, Tomohiro Yamada, Hidetc Imura, Toshio Sugahara, Dialectal and gender differences in nasalance scores in a Japanese population, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jcms.2007.07.008, 36, 1, 8-10, 2008.01, Objectives: The aim of the present study was to determine whether there are dialectal and gender-related differences in nasalance scores for normal Japanese speakers. Materials: Sixty-eight volunteers consisting of 31 males (age 23.8 +/- 2.0) and 37 females (age 23.2 +/- 2.5) were included in this study. They had no diseases affecting speech, and lived in the same region until high school from birth. According to geography, they were divided into four regional groups: Chugoku region, Kinki region, Shikoku region, and other regions. Methods: A kitsutsuki passage, which consisted of Japanese non-nasal consonants and vowels, and the Japanese vowels /al, /i/, /u/, /e/ and /o/, were read three times, and the mean nasalance scores were then obtained with a Nasometer II 6400. The scores of males and females were compared statistically by means of a Student's t-test. The differences among the three regions, Chugoku, Kinki and Shikoku region, were also investigated by means of a one-way analysis of variance (ANOVA). Results and conclusion: For all sentences and vowels, the nasalance scores were significantly different between males and females. The one-way ANOVA showed that there were no significant differences among the three regions in both males and females. (C) 2007 European Association for Cranio-Maxillofacial Surgery..
45. Harumi Kawaki, Satoshi Kubota, Akiko Suzuki, Tomohiro Yamada, Tatsushi Matsumura, Toshiko Mandal, Mayumi Yao, Takeyasu Maeda, Karen M. Lyons, Masaharu Takigawa, Functional requirement of CCN2 for intramembranous bone formation in embryonic mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 10.1016/j.bbrc.2007.11.155, 366, 2, 450-456, 2008.02, CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members, and Ccn2 null mutant mice display skeletal dysmorphisms. However, little is known concerning the roles of CCN2 during bone formation. We herein present a comparative analysis of wild-type and Ccn2 null mice to investigate the roles of CCN2 in bone development. Multiple histochemical methods were employed to analyze the effects of CCN2 deletion in vivo, and effects of CCN2 on the osteogenic response were evaluated with the isolated and cultured osteoblasts. As a result, we found a drastic reduction of the osteoblastic phenotype in Ccn2 null mutants. Importantly, addition of exogenous CCN2 promoted every step of osteoblast differentiation and rescued the attenuated activities of the Ccn2 null osteoblasts. These results suggest that CCN2 is required not only for the regulation of cartilage and subsequent events, but also for the normal intramembranous bone development. (c) 2007 Elsevier Inc. All rights reserved..
46. Kumiko Fujiwara, Tomohiro Yamada, Katsuaki Mishima, Hideto Imura, Toshio Sugahara, Morphological and immunohistochemical studies on cleft palates induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice, Congenital Anomalies, 10.1111/j.1741-4520.2008.00181.x, 48, 2, 68-73, 2008.06, Morphological and immunohistological examinations were performed to reveal the mechanisms of cleft palate induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). ICR strain mice 8-10 weeks of age were used in the study. TCDD was administered in olive oil on gestation day (GD) 12.5 with gastric tubes at 40 μg/kg. From GD 13.5 to 16.5, palates were examined by scanning electron microscopy (SEM), hematoxyline-eosin (HE) staining, and immunohistochemical staining of FGFR1/2, TGF-β3, MSX1 and LHX8. In the control group, both of the palatal shelves began elevating on GD 14.0 and finished within 6 h. After the elevation, all of the shelves had completely fused with each other on GD 14.5. In the TCDD-treated group, palatal shelves elevated 1 day later than in the control group. However, all palates had elevated by GD 15.0. After the elevation, the shelves contacted each other and fused
however, they were separated on GD16.0. HE staining showed that medial edge epithelium (MEE) was thinner in the TCDD group than in the control group. MEE observed under a high magnification (×2500) exhibited filopodia-like filaments and the cells were bulged in the control group. In contrast, in the TCDD group, no filaments were observed and the cells were flat with unclear boundaries. Immunohistologically, there were no characteristic findings except for FGFR1. FGFR1 was not expressed in the TCDD group after the fusion phase (GD 14.5). TCDD induces many morphological and molecular changes to MEE cells and causes cleft palates. © 2008 The Authors..
47. Katsuaki Mishima, Tomohiro Yamada, Asuka Sug, Hideto Imura, Toshio Sugahara, Relationships between nasalance scores and nasopharyngeal shapes in cleft palate patients, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jcms.2007.07.009, 36, 1, 11-14, 2008.01, Objectives: The aim of the present study is to clarify the relationship between nasalance scores and nasopharyngeal shapes obtained by lateral cephalograms. Patients: Eight patients who underwent a Wardill-Kilner push-back palatoplasty were included in this study. Perceptual judgment by a speech pathologist indicated that these patients had no hypernasality and no nasal emission at blowing. As normal controls, 33 non-cleft individuals, 4 boys and 10 girls aged 6 years old and 5 boys and 14 girls aged 7 years old, were investigated. Methods: Lateral cephalograms at rest were taken for both groups. For the cleft (palate) patients, lateral cephalograms at phonation /a/ and blowing were analyzed and nasometries were also performed using a kitsutsuki passage. Results and conclusion: There was no significant difference in the velar length, the pharyngeal depth, the ratio of the velar length to the pharyngeal depth and the velar angle between the cleft patients and the non-cleft individuals. Multiple regression analyses indicated that standardized regression coefficients of ratios for the velar length to the pharyngeal depth and the velar ascent at blowing had higher nasalance scores for sentences I and 3, which had high coefficients of determination, respectively. (C) 2007 European Association for Cranio-Maxillofacial Surgery..
48. K Mishima, T Yamada, A Ohura, T Sugahara, Production of a range image for facial motion analysis: A method for analyzing lip motion, COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 10.1016/j.compmedimag.2005.11.002, 30, 1, 53-59, 2006.01, To analyze the lip movement of patients with cleft lip and palate in detail, we developed a novel technique to produce a range image from a video-based motion capture system, and a unique technique to analyze lip movements in detail three-dimensionally. The accuracy of the range image obtained from the present system was investigated using a positioning actuator with a high accuracy and a known object, and by comparisons with the range images produced from a laser scanner with a cast model of a face. The lip motions of six healthy adults during phonation omega was analyzed. (c) 2005 Elsevier Ltd. All rights reserved..
49. T Yamada, Y Mori, K Mishima, T Sugahara, Nasolabial and alveolar morphology treatment following presurgical orthopaedic treatment in complete unilateral clefts of lip, alveolus and palate, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 10.1016/j.jems.2003.07.004, 31, 6, 343-347, 2003.12, Introduction: The purpose of this study was to assess the three-dimensional (3-D) facial and alveolar morphology of patients with unilateral clefts of lip, alveolus and palate by means of a computer-aided diagnosis system. Patients and Methods: Maxillary orthopaedic treatment was performed using soft/hard acrylic plates (Hotz's) within 2 weeks of birth. The nasolabial and alveolar morphology of 15 patients was evaluated before orthopaedic treatment (2 weeks of age) and before cheiloplasty (3 months of age). Nasolabial form was measured using a 3-D optical scanner. Twenty-one landmarks were extracted from the data and analysed linearly and angularly. Alveolar forms were measured with a high-accuracy contact-type 3-D digitizer on plaster casts. Seven landmarks were digitized and analysed linearly and angularly. Results: Some growth was observed in the intercanthal distance, alar width, intercommissural width, and height of the lip. There was little change in the width of the cleft lip or displacement of the columella base, while the alveolar cleft narrowed. Conclusion: Presurgical orthopaedics reduces cleft width and makes subsequent surgery easier. (C) 2003 European Association for Cranio-Maxillofacial Surgery..
50. T Yamada, Y Mori, K Minami, K Mishima, Y Tsukamoto, Surgical results of primary lip repair using the triangular flap method for the treatment of complete unilateral cleft lip and palate: A three-dimensional study in infants to four-year-old children, CLEFT PALATE-CRANIOFACIAL JOURNAL, 10.1597/1545-1569_2002_039_0497_sroplr_2.0.co_2, 39, 5, 497-502, 2002.09, Objective: To evaluate morphological problems for children with complete unilateral cleft lip and palate (UCLP).
Design and Setting: A cross-sectional study was performed on 46 patients with complete UCLP at Osaka University Dental Hospital.
Patients and Participants: The method was applied to three groups of children with UCLP (8 4-month-old infants, 18 1.5-year-old children, and 20 4-yearold children).
Main Outcome Measures: The three-dimensional coordinates of facial landmarks were extracted automatically from XYZ data sets and from photo images produced by an optical surface scanner.
Results: The intercanthal distance, nose width, and mouth width were closer to those of normal children in the older group. Deviation of the columella toward the noncleft side was smaller in the 4-year-old group. The angle of the nasal tip was large in all groups. Asymmetry of the ala was conspicuous at the upper part of the nose in the vertical dimension. Asymmetry of the nostril was observed in the vertical dimension and in the anteroposterior dimension in the 4-year-old group. The angle of the Cupid's bow was obtuse on the noncleft side, and the bottom of the Cupid's bow deviated toward the cleft side. The Cupid's bow was longer on the noncleft side. Protrusion of the vermilion was poor in all groups..

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