| 1. |
Ryoga Suzuki , Kenichi Horisawa , Shizuka Miura , Yasuyuki Ohkawa , Atsushi Suzuki, Elucidation of Reprogramming Mechanism in Induced Fetal Intestinal Progenitor Cells, 第24回生医研リトリート2022, 2022.07. |
| 3. |
Kenichi Horisawa, Shizuka Miura, Yoshihiro Izumi, Takeshi Bamba, Atsushi Suzuki, Trans-omic analysis for metabolic remodeling during liver regeneration, The 29th Hot Spring Harbor International Symposium, 2020.02, The liver is the central metabolic organ that produces energy for life activities and detoxifies various extrinsic and intrinsic harmful substances. Also, the liver is one of the organs capable of regeneration. After deletion of two-thirds of the total liver mass, the remaining liver tissue immediately enlarge and recover hepatic function. Remodeling of the metabolic process in the injured liver is a candidate of the responsible mechanism regulating liver regeneration. It is known that the concentration of various metabolites from the central metabolic pathways affects cellular states through the extensive epigenetic change of chromatin. Also, several metabolites including a group of lipid-derived molecules eicosanoids are known to work as signal mediators for cell proliferation. Moreover, because regenerative potential of the liver attenuates in the aging process, comparison of the regenerating livers between young and old mice could elucidate the molecular mechanism of liver regeneration. Thus, in this study, we performed a metabolomic analysis using liver samples obtained from young and old mice before and after the partial hepatectomy to elucidate the molecular machinery and discover the key metabolites regulating liver regeneration. In addition, we performed a trans-omic analysis using our metabolome data and a public transcriptome data set obtained from the regenerating liver. We present the data in this symposium and hope a lively discussion.. |
