Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Shinsuke Uda Last modified date:2023.06.19

Associate Professor / Division of Integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation / Medical Research Center for High Depth Omics / Medical Institute of Bioregulation

1. Shinsuke Uda, Application of information theory in systems biology, Biophysical Reviews, 10.1007/s12551-020-00665-w, 2020.04, Over recent years, new light has been shed on aspects of information processing in cells. The quantification of information, as described by Shannon’s information theory, is a basic and powerful tool that can be applied to various fields, such as communication, statistics, and computer science, as well as to information processing within cells. It has also been used to infer the network structure of molecular species. However, the difficulty of obtaining sufficient sample sizes and the computational burden associated with the high-dimensional data often encountered in biology can result in bottlenecks in the application of information theory to systems biology. This article provides an overview of the application of information theory to systems biology, discussing the associated bottlenecks and reviewing recent work..
2. Shinsuke Uda, Shinya Kuroda, Analysis of cellular signal transduction from an information theoretic approach, Seminars in Cell and Developmental Biology, 10.1016/j.semcdb.2015.12.011, 2016.03, Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output..