Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Hiroki Mitoma Last modified date:2021.08.12

Assistant Professor / Department of Clinical Immunology and Rheumatology / Infectious Disease / Kyushu University Hospital

1. Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus, Clin Exp Rheumatol, 2021 Mar 22. Online ahead of print., 2021.03.
2. Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Shota Nakano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells, Journal of Immunology, 10.4049/jimmunol.1901304, 204, 8, 2088-2097, 2020.04.
3. Makio Furukawa, Chikako Kiyohara, Takahiko Horiuchi, Hiroshi Tsukamoto, Hiroki Mitoma, yasutaka kimoto, Ayumi Uchino, Misato Nakagawa, Kensuke Oryoji, Terufumi Shimoda, Koichi Akashi, Quality of life in Japanese female patients with systemic lupus erythematosus
Evaluation using the Short Form 36 Health Survey, Modern Rheumatology, 10.3109/14397595.2015.1060668, 26, 2, 240-247, 2016.03, Objective. Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. Methods. We collected basic and lifestyle-related, clinical, and treatment characteristics among 119 female Japanese patients with systemic lupus erythematosus (SLE). Odds ratios (ORs) and their 95% confidence intervals were assessed for associations between HRQoL and selected factors. Results. Irregularity of sleep was significantly associated with risk of lower role physical (RP) (OR = 8.27), vitality (VT) (OR = 8.45), and role emotional (OR = 10.7) domains. Compared with clerical work, non-clerical work was significantly associated with risk of lower RP (OR = 7.39), and unemployment was significantly associated with risk of lower VT (OR = 41.0). Daily soybean intake was associated with improved General Health or GH (OR = 0.17). Compared with Systemic Lupus Collaborative Clinics Damage Index (SDI) = 0, SDI > 2 was associated with risk of lower PF (OR = 7.88), RP (OR = 4.29), and bodily pain (OR = 3.06) domains. Conclusion. Reduced HRQoL was observed in our SLE patients. Interventions addressing sleep and work disturbances, as well as daily soybean consumption, could alter the HRQoL of SLE patients..
4. Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, Shun Ichiro Ota, Yuri Ota, Hiroki Mitoma, Mitsuteru Akahoshi, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Hiroshi Tsukamoto, Koichi Akashi, Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes, Immunology, 10.1111/imm.12667, 150, 1, 64-73, 2017.01, Interleukin-33 (IL-33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity-mediated allergic inflammation. Allergy-related innate myeloid cells such as eosinophils, basophils and mast cells express the IL-33 receptor (IL-33R), but it is still unknown how IL-33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL-33R was expressed on eosinophil progenitors (EoPs), basophil progenitors (BaPs) and mast cell progenitors (MCPs). In the presence of IL-33, these progenitors did not expand, but produced a high amount of Th2 and pro-inflammatory cytokines such as IL-9, IL-13, IL-1β and IL-6. The amount of cytokines produced by these progenitors was greater than that by mature cells. In vivo, IL-33 stimulated the expansion of EoPs, but it was dependent upon the elevated serum IL-5 that is presumably derived from type 2 innate lymphoid cells that express functional IL-33R. These data collectively suggest that EoPs, BaPs and MCPs are not only the sources of allergy-related granulocytes, but can also be sources of allergy-related cytokines in IL-33-induced inflammation. Because such progenitors can differentiate into mature granulocytes at the site of inflammation, they are potential therapeutic targets in IL-33-related allergic diseases..
5. Otsuka Y, Kiyohara C, Kashiwado Y, Sawabe T, Nagano S, Kimoto Y, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T, Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study, PLOS ONE, 10.1371/journal.pone.0196368, 13, 4, 2018.04.
6. Ota, Yuri, Hiroaki Niiro, Ota S, Ueki N, Tsuzuki H, Nakayama T, Mishima K, Higashioka K, Siamak JT, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Kukita A, Yamada H, Tsukamoto H, koichi akashi, Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-016-0957-6, 18, 2016.03.
7. Okugawa Y, Toiyama Y, Toden S, Hiroki Mitoma, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A, Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer, Gut, 10.1136/gutjnl-2015-309359, 66, 1, 107-117, 2017.01.
8. Ayano, Masahiro, Tsukamoto H, Kohno K, Ueda N, Tanaka A, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi, koichi akashi, Increased CD226 Expression on CD8(+) T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis, JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.1403046, 195, 3, 892-900, 2015.08.
9. Furukawa M, Kiyohara C, Takahiko Horiuchi, Tsukamoto H, Hiroki Mitoma, Yasutaka Kimoto, Uchino A, Nakagawa M, Oryoji K, Shimoda T, koichi akashi, Quality of life in Japanese female patients with systemic lupus erythematosus: Evaluation using the Short Form 36 Health Survey., Mod Rheumatol., 26, 2, 240-247, 2016.03.
10. Tanaka, Atsushi, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Kimoto, Yasutaka, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Tada, Yoshifumi, Takahiko Horiuchi, koichi akashi, Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-015-0547-z, 17, 2015.02.
11. Weng, Leiyun, Hiroki Mitoma, Tricot, Coline, Bao, Musheng, Liu, Ying, Zhang, Zhiqiang, Liu, Yong-Jun, The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA-Induced NLRP3 Inflammasome Activation, JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.1401448, 193, 7, 3676-3682, 2014.10.
12. Sugimoto, Naoshi, Hiroki Mitoma, Kim, Taeil, Hanabuchi, Shino, Liu, Yong-Jun, Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 10.1073/pnas.1400139111, 111, 21, 7747-7752, 2014.05.
13. Sha, Wenwen, Hiroki Mitoma, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, Yong-Jun, Human NLRP3 inflammasome senses multiple types of bacterial RNAs, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 10.1073/pnas.1412487111, 111, 45, 16059-16064, 2014.11.
14. Hiroki Mitoma, Hiroshi Tsukamoto, The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α., Inflamm Bowel Dis, 10.1097/MIB.0b013e318280b169, 19, 6, 1224-1231, 2013.05.