| 1. |
Ono N, Kai T, Takeyama Y, Inoue Y, Ueda N, Nagano S, Ohta S, Inoue H, Sawabe T, Chifu Y, Yoshizawa S, Oryoji K, Kimoto Y, Miyake K, Ayano M, Mitoma H, Arinobu Y, Miyamura T, Horiuchi T, Akashi K, Tada Y, Niiro H, Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering, Int J Rheum Dis. , 27, 1, e15009, 2024.01. |
| 2. |
Sagawa F, Yamada H, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kondo M, Nakashima Y, Akashi K, Horiuchi T, Niiro H, Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis., RMD Open, 10.1136/rmdopen-2023-003693, 10, 1, e003693, 2024.01. |
| 3. |
Yusuke Kashiwado, Yasutaka Kimoto, Shiro Ohshima, Takuya Sawabe, Kensuke Irino, Shota Nakano, Junki Hiura, Akiko Yonekawa, Qiaolei Wang, Goro Doi, Masahiro Ayano, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Hiroaki Niiro, Taeko Hotta, Dongchon Kang, Nobuyuki Shimono, Koichi Akashi, Tsutomu Takeuchi, Takahiko Horiuchi, Immunosuppressive therapy and humoral response to third mRNA COVID-19 vaccination with a six-month interval in rheumatic disease patients, Rheumatology (Oxford) , 10.1093/rheumatology/kead275, 2023.06. |
| 4. |
Fujimoto, Sho; Arinobu, Yojiro; Miyawaki, Kohta; Ayano, Masahiro; Mitoma, Hiroki; Kimoto, Yasutaka; Ono, Nobuyuki; Akashi, Koichi; Horiuchi, Takahiko; Niiro, Hiroaki, Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus, RHEUMATOLOGY, 10.1093/rheumatology/kead082, 2023.02. |
| 5. |
Yokoyama, Kana; Mitoma, Hiroki; Kawano, Shotaro; Yamauchi, Yusuke; Wang, Qiaolei; Ayano, Masahiro; Kimoto, Yasutaka; Ono, Nobuyuki; Arinobu, Yojiro; Akashi, Koichi; Horiuchi, Takahiko; Niiro, Hiroaki, CEACAM 1, 3, 5 and 6-positive classical monocytes correlate with interstitial lung disease in early systemic sclerosis, FRONTIERS IN IMMUNOLOGY, 10.3389/fimmu.2022.1016914, 13, 2022.10. |
| 6. |
Ayano, Masahiro; Kimoto, Yasutaka; Mitoma, Hiroki; Akahoshi, Mitsuteru; Ono, Nobuyuki; Arinobu, Yojiro; Akashi, Koichi; Horiuchi, Takahiko; Niiro, Hiroaki, Safety and efficacy of switching immunosuppressive drugs for maintenance treatment in patients with systemic lupus erythematosus: A retrospective cohort study, MODERN RHEUMATOLOGY, 10.1093/mr/roac100, 2022.08. |
| 7. |
Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Comparative efficacy and safety of mizoribine and mycophenolate mofetil for treating systemic lupus erythematosus: a retrospective cohort study, THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 10.1177/1759720X221096367, 14, 2022.05. |
| 8. |
Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi, and Hiroaki Niiro, Association of circulating SLAMF7(+)Tfh1 cells with IgG4 levels in patients with IgG4-related disease, BMC IMMUNOLOGY, 10.1186/s12865-020-00361-0, 21, 1, 2020.06. |
| 9. |
Kazuhiko Higashioka, Yoshikane Kikushige, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Makoto Kikukawa, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Koichi Akashi, and Hiroaki Niiro, Generation of a novel CD30(+)B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis, MODERN RHEUMATOLOGY, 10.1111/cei.13477, 201, 3, 233-243, 2020.09. |
| 10. |
Qiaolei Wang, Daisuke Oryoji, Hiroki Mitoma, Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi, Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents, FRONTIERS IN IMMUNOLOGY, 10.3389/fimmu.2020.02042, 11, 2020.08. |
| 11. |
Tsuyoshi Nakayama, Motoki Yoshimura, Kazuhiko Higashioka, Kohta Miyawaki, Yuri Ota, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Type 1 helper T cells generate CXCL9/10-producing T-bet(+) effector B cells potentially involved in the pathogenesis of rheumatoid arthritis, CELLULAR IMMUNOLOGY, 10.1016/j.cellimm.2020.104263, 360, 2021.02. |
| 12. |
Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro, Human PD-1(hi)CD8(+) T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis, FRONTIERS IN IMMUNOLOGY, 10.3389/fimmu.2021.654623, 12, 2021.03. |
| 13. |
Kensuke Irino, Yojiro Arinobu, Masahiro Ayano, Shotaro Kawano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus, LUPUS, 10.1177/09612033211031989, 30, 10, 1637-1643, 2021.09. |
| 14. |
Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, and Hiroaki Niiro, Increased Proportion of CD226(+) B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus, FRONTIERS IN IMMUNOLOGY, 10.3389/fimmu.2021.713225, 12, 2021.07. |
| 15. |
Kazuo Kushimoto, Masahiro Ayano, Keisuke Nishimura, Miki Nakano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi & Hiroaki Niiro, HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-021-02618-4, 23, 1, 2021.09. |
| 16. |
Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Hydroxychloroquine versus tacrolimus for the treatment of persistently active systemic lupus erythematosus, MODERN RHEUMATOLOGY, 10.1093/mr/roab010, 32, 2, 345-350, 2022.02. |
| 17. |
Shotaro Kawano, Hiroki Mitoma, Shoichiro Inokuchi, Yusuke Yamauchi, Kana Yokoyama, Jumpei Nogami, Yuichiro Semba, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro, TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells, JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.2100323, 208, 5, 1057-1065, 2022.03. |
| 18. |
Yusuke Kashiwado, Yasutaka Kimoto, Takuya Sawabe, Kensuke Irino, Shota Nakano, Junki Hiura, Qiaolei Wang, Shotaro Kawano, Masahiro Ayano, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Hiroaki Niiro, Taeko Hotta, Dongchon Kang, Koichi Akashi, Shiro Ohshima, Tsutomu Takeuchi, and Takahiko Horiuchi, Antibody response to SARS-CoV-2 mRNA vaccines in patients with rheumatic diseases in Japan: Interim analysis of a multicentre cohort study, MODERN RHEUMATOLOGY, 10.1093/mr/roac030, 2022.03. |
| 19. |
Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Comparative efficacy and safety of mizoribine and mycophenolate mofetil for treating systemic lupus erythematosus: a retrospective cohort study, THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 10.1177/1759720X221096367, 14, 2022.05. |
| 20. |
Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi & Hiroaki Niiro , Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus., Scientific reports, 10.1038/s41598-021-95711-2, 11, 1, 16162-16162, 2021.08. |
| 21. |
Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus, Clin Exp Rheumatol, 2021 Mar 22. Online ahead of print., 2021.03. |
| 22. |
Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Shota Nakano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells, Journal of Immunology, 10.4049/jimmunol.1901304, 204, 8, 2088-2097, 2020.04. |
| 23. |
Makio Furukawa, Chikako Kiyohara, Takahiko Horiuchi, Hiroshi Tsukamoto, Hiroki Mitoma, yasutaka kimoto, Ayumi Uchino, Misato Nakagawa, Kensuke Oryoji, Terufumi Shimoda, Koichi Akashi, Quality of life in Japanese female patients with systemic lupus erythematosus
Evaluation using the Short Form 36 Health Survey, Modern Rheumatology, 10.3109/14397595.2015.1060668, 26, 2, 240-247, 2016.03, Objective. Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. Methods. We collected basic and lifestyle-related, clinical, and treatment characteristics among 119 female Japanese patients with systemic lupus erythematosus (SLE). Odds ratios (ORs) and their 95% confidence intervals were assessed for associations between HRQoL and selected factors. Results. Irregularity of sleep was significantly associated with risk of lower role physical (RP) (OR = 8.27), vitality (VT) (OR = 8.45), and role emotional (OR = 10.7) domains. Compared with clerical work, non-clerical work was significantly associated with risk of lower RP (OR = 7.39), and unemployment was significantly associated with risk of lower VT (OR = 41.0). Daily soybean intake was associated with improved General Health or GH (OR = 0.17). Compared with Systemic Lupus Collaborative Clinics Damage Index (SDI) = 0, SDI > 2 was associated with risk of lower PF (OR = 7.88), RP (OR = 4.29), and bodily pain (OR = 3.06) domains. Conclusion. Reduced HRQoL was observed in our SLE patients. Interventions addressing sleep and work disturbances, as well as daily soybean consumption, could alter the HRQoL of SLE patients.. |
| 24. |
Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, Shun Ichiro Ota, Yuri Ota, Hiroki Mitoma, Mitsuteru Akahoshi, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Hiroshi Tsukamoto, Koichi Akashi, Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes, Immunology, 10.1111/imm.12667, 150, 1, 64-73, 2017.01, Interleukin-33 (IL-33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity-mediated allergic inflammation. Allergy-related innate myeloid cells such as eosinophils, basophils and mast cells express the IL-33 receptor (IL-33R), but it is still unknown how IL-33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL-33R was expressed on eosinophil progenitors (EoPs), basophil progenitors (BaPs) and mast cell progenitors (MCPs). In the presence of IL-33, these progenitors did not expand, but produced a high amount of Th2 and pro-inflammatory cytokines such as IL-9, IL-13, IL-1β and IL-6. The amount of cytokines produced by these progenitors was greater than that by mature cells. In vivo, IL-33 stimulated the expansion of EoPs, but it was dependent upon the elevated serum IL-5 that is presumably derived from type 2 innate lymphoid cells that express functional IL-33R. These data collectively suggest that EoPs, BaPs and MCPs are not only the sources of allergy-related granulocytes, but can also be sources of allergy-related cytokines in IL-33-induced inflammation. Because such progenitors can differentiate into mature granulocytes at the site of inflammation, they are potential therapeutic targets in IL-33-related allergic diseases.. |
| 25. |
Otsuka Y, Kiyohara C, Kashiwado Y, Sawabe T, Nagano S, Kimoto Y, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T, Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study, PLOS ONE, 10.1371/journal.pone.0196368, 13, 4, 2018.04. |
| 26. |
Ota, Yuri, Hiroaki Niiro, Ota S, Ueki N, Tsuzuki H, Nakayama T, Mishima K, Higashioka K, Siamak JT, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Kukita A, Yamada H, Tsukamoto H, koichi akashi, Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-016-0957-6, 18, 2016.03. |
| 27. |
Okugawa Y, Toiyama Y, Toden S, Hiroki Mitoma, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A, Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer, Gut, 10.1136/gutjnl-2015-309359, 66, 1, 107-117, 2017.01. |
| 28. |
Ayano, Masahiro, Tsukamoto H, Kohno K, Ueda N, Tanaka A, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi, koichi akashi, Increased CD226 Expression on CD8(+) T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis, JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.1403046, 195, 3, 892-900, 2015.08. |
| 29. |
Furukawa M, Kiyohara C, Takahiko Horiuchi, Tsukamoto H, Hiroki Mitoma, Yasutaka Kimoto, Uchino A, Nakagawa M, Oryoji K, Shimoda T, koichi akashi, Quality of life in Japanese female patients with systemic lupus erythematosus: Evaluation using the Short Form 36 Health Survey., Mod Rheumatol., 26, 2, 240-247, 2016.03. |
| 30. |
Tanaka, Atsushi, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Kimoto, Yasutaka, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Tada, Yoshifumi, Takahiko Horiuchi, koichi akashi, Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis, ARTHRITIS RESEARCH & THERAPY, 10.1186/s13075-015-0547-z, 17, 2015.02. |
| 31. |
Weng, Leiyun, Hiroki Mitoma, Tricot, Coline, Bao, Musheng, Liu, Ying, Zhang, Zhiqiang, Liu, Yong-Jun, The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA-Induced NLRP3 Inflammasome Activation, JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.1401448, 193, 7, 3676-3682, 2014.10. |
| 32. |
Sugimoto, Naoshi, Hiroki Mitoma, Kim, Taeil, Hanabuchi, Shino, Liu, Yong-Jun, Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 10.1073/pnas.1400139111, 111, 21, 7747-7752, 2014.05. |
| 33. |
Sha, Wenwen, Hiroki Mitoma, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, Yong-Jun, Human NLRP3 inflammasome senses multiple types of bacterial RNAs, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 10.1073/pnas.1412487111, 111, 45, 16059-16064, 2014.11. |
| 34. |
Hiroki Mitoma, Hiroshi Tsukamoto, The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α., Inflamm Bowel Dis, 10.1097/MIB.0b013e318280b169, 19, 6, 1224-1231, 2013.05. |
