九州大学 研究者情報
総説一覧
宮田 暖(みやた のん) データ更新日:2022.06.14

助教 /  理学研究院 化学部門 有機・生物化学講座


総説, 論評, 解説, 書評, 報告書等
1. Yukio Fujiki, Yuichi Abe, Yuuta Imoto, Akemi J. Tanaka, Kanji Okumoto, Masanori Honsho, Shigehiko Tamura, Non Miyata, Toshihide Yamashita, Wendy K. Chung, Tsuneyoshi Kuroiwa, Recent insights into peroxisome biogenesis and associated diseases, Journal of cell science, 10.1242/jcs.236943, 2020.05, [URL], Peroxisomes are single-membrane organelles present in eukaryotes. The functional importance of peroxisomes in humans is represented by peroxisome-deficient peroxisome biogenesis disorders (PBDs), including Zellweger syndrome. Defects in the genes that encode the 14 peroxins that are required for peroxisomal membrane assembly, matrix protein import and division have been identified in PBDs. A number of recent findings have advanced our understanding of the biology, physiology and consequences of functional defects in peroxisomes. In this Review, we discuss a cooperative cell defense mechanisms against oxidative stress that involves the localization of BAK (also known as BAK1) to peroxisomes, which alters peroxisomal membrane permeability, resulting in the export of catalase, a peroxisomal enzyme. Another important recent finding is the discovery of a nucleoside diphosphate kinase-like protein that has been shown to be essential for how the energy GTP is generated and provided for the fission of peroxisomes. With regard to PBDs, we newly identified a mild mutation, Pex26-F51L that causes only hearing loss. We will also discuss findings from a new PBD model mouse defective in Pex14, which manifested dysregulation of the BDNF-TrkB pathway, an essential signaling pathway in cerebellar morphogenesis. Here, we thus aim to provide a current view of peroxisome biogenesis and the molecular pathogenesis of PBDs..
2. Non Miyata, Kanji Okumoto, Yukio Fujki, Cell Death or Survival Against Oxidative Stress, Subcellular Biochemistry, 10.1007/978-981-13-2233-4_20, 2018.10.
3. Kanji Okumoto, Non Miyata, Yukio Fujiki, Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells, Subcellular Biochemistry, 10.1007/978-981-13-2233-4_12, 2018.10.
4. 宮田 暖,久下 理, ミトコンドリア内リン脂質輸送と代謝, 細胞, 2018.07.
5. Non Miyata, Osamu Kuge, Fmp30, Mdm31, and Mdm32 Function in Ups1-Independent Cardiolipin Accumulation Under Low Phosphatidylethanolamine Conditions, Contact, 2018.03.
6. Yukio Fujiki, Non Miyata, Satoru Mukni, Kanji Okumoto, Emily H. Cheng, BAK regulates catalase release from peroxisomes., Molecular and Cellular Oncology, 2017.03.
7. 宮田 暖, 久下 理, 膜接触部位を介したミトコンドリアへのリン脂質輸送, 実験医学, 2015.10.
8. 藤木 幸夫, 宮田 暖, 奥本 寛治, 田村 茂彦, 糸山 彰徳, 本庄 雅則, ペルオキシソームの形成・制御とその障害, 生体の科学, 2012.10.
9. 藤木 幸夫, 向井 悟, 宮田 暖, 宮内 康弘, ペルオキシソーム移行シグナル2型(PTS2)タンパク質の輸送とその制御機構, 生体の科学, 2012.10.
10. 藤木 幸夫, 宮田 暖, 松園 裕嗣, 松崎 高志, 本庄 雅則, ペルオキシソームの形成・制御とその障害による高次機能の破綻, 実験医学, 2010.08.

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