||Hiroe KAKEHASHI, Takao Ando, Tokutaro Minamizato, Shinichiro Kuroshima, Yuya Nakatani, Atsushi Kawakami, Izumi Asahina, Administration of teriparatide improves the symptoms of advanced bisphosphonate-related osteonecrosis of the jaw: preliminary findings., Int J Oral Maxillofac Surg. 2015 Aug 21. pii: S0901-5027(15)01201-1. doi: 10.1016/j.ijom.2015.07.018. [Epub ahead of print], 2015.08, Teriparatide is a synthetic polypeptide hormone that contains the 1–34 amino
acid fragment of the recombinant human parathyroid hormone that stimulates bone
formation. Currently it is approved only for the treatment of osteoporosis. Here, we
report the outcomes of daily teriparatide injections for the treatment of bisphosphonaterelated
osteonecrosis of the jaw in ten patients. Two of ten cases dropped out due to
adverse events. Of the remaining eight cases, seven exhibited clinical improvement of
the jaw-related symptoms of osteonecrosis and the progression of the sequestration, while one case did not show any change in the symptoms. Administration of teriparatide in patients with osteonecrosis of the jaw promotes bone formation and subsequent sequestration over a short period of time. Our results suggest that adjunctive teriparatide therapy is a viable and effective option for treating osteonecrosis of the jaw..
||Shin-ichiro YAMADA, Hiroe KAKEHASHI, A New Strategy for Surgical Intervention of Bisphosphonate-Related Osteonecrosis of the Jaw : A retrospective study.
, ACTA MEDICA NAGASAKIENSIA, 2015.12.
||Seigo Ohba, Hiroe KAKEHASHI, The migration pathway of an extracted maxillary third molar into the buccal fat pad , Odontology
, 102, 2, 339-342, 2014.07.
||Hiroe KAKEHASHI, Parotid gland myoepithelioma with remarkable cystic formation : A case report, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology , 25, 2, 183-188, 2012.05.
||Hiroe KAKEHASHI, Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E., The Journal of Immunology , 179, 9, 5728-5737, 2007.11.