Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Fukata Mitsuhiro Last modified date:2023.07.08

Assistant Professor / Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital / Hematology, Oncology & Cardiovascular medicine / Kyushu University Hospital


Reports
1. Shohei Moriyama, Mitsuhiro Fukata, Taku Yokoyama, Shohei Ueno, Takuya Nunomura, Yasuo Mori, Koji Kato, Toshihiro Miyamoto, Koichi Akashi, Case Report: Cardiac Tamponade in Association With Cytokine Release Syndrome Following CAR-T Cell Therapy., Frontiers in cardiovascular medicine, 10.3389/fcvm.2022.848091, Vol.9, p.848091, 2022.03, Chimeric antigen receptor T (CAR-T) cell therapy has been shown to have substantial efficacy against refractory hematopoietic malignancies. However, it frequently causes cytokine release syndrome (CRS) as a treatment-specific adverse event. Although cardiovascular events associated with CAR-T cell therapy have been increasingly reported recently, pericardial disease is a rare complication and its clinical course is not well characterized. Here, we report a case of acute pericardial effusion with cardiac tamponade after CAR-T cell therapy. Case Summary: A 59-year-old man with refractory diffuse large B-cell lymphoma underwent CAR-T cell therapy. Grade 2 CRS was observed on day 0; it progressed to grade 4 on day 7 and was accompanied by a fever over 39°C, hypoxia requiring intubation, hypotension requiring the use of a vasopressor agent, and supraventricular tachycardia. Although cardiac function was preserved, marked pericardial effusion with the collapse of the right heart was detected on echocardiography. Since pericardiocentesis was considered to have a high complication risk due to severe myelosuppression, medications for CRS were prioritized. Tocilizumab, an interleukin-6 inhibitor, and high-dose methylprednisolone (1 g/day for 3 days) were administered for the management of severe CRS. On day 8, the pericardial effusion decreased, and the hemodynamic status markedly stabilized. CRS did not exacerbate after the steroid dose was reduced. Further, lymphoma size reduced after the induction of CAR-T cell therapy, and tumor regrowth was not noted at 3 months after CAR-T cell infusion. Conclusion: Interleukin-6 pathway inhibitors and corticosteroid therapy should be considered in the context of CRS for significant pericardial effusion after CAR-T cell therapy in the acute phase..
2. Maruyama Toru, Ueda Jin, Fukata Mitsuhiro, Nakaji Gen, Karashima Eiji, Simazu Hideki, Nakamura Hirofumi, Hiramatsu Sinichi, Odashiro Keita, PJ-849 Comparison of precordial manual recordings by event-recorder with standard precordial ECG as a reference(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Circulation journal : official journal of the Japanese Circulation Society, Vol.72, p.725, 2008.03.
3. Maruyama Toru, Ueda Jin, Fukata Mitsuhiro, Nakaji Gen, Karashima Eiji, Simazu Hideki, Nakamura Hirofumi, Hiramatsu Shinichi, Odashiro Keita, PJ-025 Further echocardiographic assessment of pulmomary vein flow velocity in focal atrial fibrillation: Longitudinal study(Arrhythmia, diagnosis/Pathophysiology/EPS(12)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Circulation journal : official journal of the Japanese Circulation Society, Vol.72, p.516, 2008.03.
4. Noda Hirotaka, Moriyama Shohei, Irie Kei, Fujita Kazumasa, Yokoyama Taku, Fukata Mitsuhiro, Arita Takeshi, Odashiro Keita, Maruyama Toru, Mawatari Shiro, Fujino Takehiko, Akashi Koichi, Plasma and Erythrocyte Membrane Plasmalogen Diminished in Severe Atherosclerotic Patients Undergoing Endovascular Therapy, 膜 = Membrane, Vol.42, No.6, pp.242-249, 2017.11.
5. IMPROVE score is useful for prediction of bleeding in advanced GI cancer patients with venous thromboembolism.
6. Comparison of precordial ECG recorded by event-recorder with those by standard 12-lead systems.
7. A Case of Endovascular Revascularization for Chronic Mesenteric Ischemia (CMI).
8. A multicenter study to assess upper digestive tract symptoms caused by dabigatran etexilate administered to the patients with non-valvular atrial fibrillation.
9. 横山 拓, 有田 武史, 原 英彦, 児玉 浩幸, 野田 裕剛, 深田 光敬, 安田 潮人, 橋本 剛, 日浅 謙一, 園田 拓道, 小田代 敬太, 丸山 徹, CTによる人工弁のPerpendicular viewは経皮的弁周囲逆流閉鎖治療の強力な補助である, 日本心血管インターベンション治療学会抄録集, Vol.25回, p.MP237, 2016.07.
10. 藤田 一允, 森山 祥平, 野田 裕剛, 深田 光敬, 有田 武史, 小田代 敬太, 赤司 浩一, 重症大動脈弁狭窄症を伴う肺高血圧症の有病率と血行動態所見(Prevalence and Hemodynamic Presentation of Pulmonary Hypertension with Severe Aortic Stenosis), 日本循環器学会学術集会抄録集, Vol.81回, pp.PJ-287, 2017.03.
11. 丸山 徹, 森山 祥平, 藤田 一允, 入江 圭, 野田 裕剛, 横山 拓, 深田 光敬, 有田 武史, 小田代 敬太, 赤司 浩一, 日本人青年において身体計測値が心電図パラメーターに及ぼす影響(Effects of Antropometrics on Electrocardiographic Parameters in Japanese Youths), 日本循環器学会学術集会抄録集, Vol.81回, pp.PJ-468, 2017.03.
12. 藤田 一允, 入江 圭, 森山 祥平, 横山 拓, 安田 潮人, 深田 光敬, 有田 武史, 小田代 敬太, 丸山 徹, 赤司 浩一, 後内側乳頭筋ついで前外側乳頭筋に起源をもつ特発性心室期外収縮に対して高周波心筋焼灼術を施行した1例, 福岡医学雑誌 = Fukuoka acta medica, 10.15017/1931474, Vol.108, No.12, pp.244-252, 2017.12, 症例は61 歳の男性で全身倦怠感を主訴に来院した.ホルター心電図では右脚ブロック型で上方軸の心室期外収縮が頻発しており,心臓超音波検査では左室壁運動がびまん性に低下し左室駆出率が45%であった.薬物治療に抵抗性の心室期外収縮に対して心筋焼灼術を行った.臨床電気生理学検査では後内側乳頭筋でのペースマップが最良で,同部にプルキンエ電位も認めたため通電を行ったところ心室期外収縮は消失し左室駆出率も63%に回復した.しかし1年半後に右脚ブロック型で下方軸の心室期外収縮が頻発し始めたため前回と同様に心筋焼灼術を行った.臨床電気生理学検査では心室期外収縮は前外側乳頭筋に起源があり同部への通電で心室期外収縮は消失した.乳頭筋起源の不整脈は巣状興奮による場合が多いとされるが今回プルキンエ線維網を介する興奮旋回による機序が強く疑われた.また乳頭筋起源の心室期外収縮は致死的ではないものの心機能を低下させたり,心筋焼灼術に難渋するため注意深い経過観察が必要である..
13. 深田 光敬, 有田 武史, 藤田 一允, 森山 祥平, 入江 圭, 野田 裕隆, 横山 拓, 小田代 敬太, 丸山 徹, 赤司 浩一, カテーテルアブレーション後の肺静脈閉塞に対し、2回のカテーテルインターベンションを施行した症例, 日本心血管インターベンション治療学会抄録集, Vol.26回, p.MP195, 2017.07.
14. 深田 光敬, 入江 圭, 有田 武史, 小田代 敬太, 丸山 徹, 赤司 浩一, 実質的心臓モデルおよびコンピュータ支援エンジニアリングを用いた高周波hot balloonの接触力の評価(Evaluation of Contact Force of Radiofrequency Hot Balloon by Using a Substantial Heart Model and Computer Aided Engineering), 日本循環器学会学術集会抄録集, Vol.83回, pp.PJ053-3, 2019.03.
15. Fukata Mitsuhiro, Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome, Journal of Arrhythmia, 2017.02.