Kyushu University [Shingo Kobayashi (Research Associate Professor) Institute for Materials Chemistry and Engineering, Department of Soft Materials Chemistry]

Shingo Kobayashi

Last modified date：2023.12.06

Research Associate Professor / Department of Soft Materials Chemistry / Institute for Materials Chemistry and Engineering

Papers

1.	Shingo Kobayashi and Masaru Tanaka , Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes, Molecular Systems Design & Engineering, 10.1039/D3ME00063J, 2023.06, Ring-opening metathesis polymerisation (ROMP) has become a popular method for synthesising complex functional polymers owing to the high functional group tolerance of metathesis catalysts. In recent years, ROMP has emerged as an indispensable approach for the design and synthesis of polymeric biomaterials, allowing for precise control of polymer structure and introduction of complex polar functional groups that are challenging to access through conventional polymerisation methods. In this review, we present examples of precision polymer synthesis with polar functional groups and their utilisation as soft-biomaterials in biotechnology and biomedical fields. Specifically, we focus on two approaches: the underexplored ROMP of functionalised monocyclic alkenes and the dominant methods of synthesising biomaterials using functionalised norbornene..
2.	Riku Saeki, Shingo Kobayashi, Rena Shimazui, Teruki Nii, Akihiro Kishimura, Takeshi Mori, Masaru Tanaka, Yoshiki Katayama, Characterization of polypropyleneimine as an alternative transfection reagent, Analytical Sciences, 10.1007/s44211-023-00284-x, 2023.03.
3.	Hiroko KURITA, Shingo KOBAYASHI, Takahisa ANADA, Masaru TANAKA and Mitsugu TODO, Cellular characterization of hiPS-CMs cultured on PMEA analogous polymers with different bound water content, 九州大学大学院総合理工学報告, 10.15017/6786935, 45, 1, 1-6, 2023.09.
4.	Saeki, Riku; Kobayashi, Shingo; Shimazui, Rena; Nii, Teruki; Kishimura, Akihiro; Mori, Takeshi; Tanaka, Masaru; Katayama, Yoshiki, Characterization of polypropyleneimine as an alternative transfection reagent, ANALYTICAL SCIENCES, 10.1007/s44211-023-00284-x, 39, 6, 1015-1020, 2023.06.
5.	Toyokawa, Y., Kobayashi, S., Tsuchiya, H., Shibuya, T., Aoki, M., Sumiya, J., Ooyama, S., Ishizawa, T., Makino, N., Ueno, Y., Tanaka, M., A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition, Materials Science and Engineering C, 10.1016/j.msec.2020.111386, 120, 111386-111386, 2021.01, The adhesion and deformation behavior of proteins at the inner surface of fully covered, self-expandable metallic stents coated with biocompatible polymers, poly(2-methoxyethyl acrylate) (PMEA) and poly(3-methoxypropyl acrylate) (PMC3A), were analyzed. Model bile solution, proteins, and bacteria were used to unravel the inhibitory ability of the polymer coatings. Adsorbance of proteins and adherence of bacteria were both strongly inhibited by the polymer coatings. Circulation tests were performed under clinical conditions using human bile from patients. Adsorption/deformation of proteins and early-stage sludge formation were inhibited on stent surfaces coated with PMEA derivatives. The present study revealed that early-stage biliary sludge formation on PMEA- and PMC3A-coated stents was suppressed due to the strong resistance of the polymers to protein adsorption/deformation, brought about by intermediate water in hydrated polymer coatings, which is not present in conventional coating materials, such as silicone and polyurethane..
6.	Kuo, A.-T., Urata, S., Koguchi, R., Sonoda, T., Kobayashi, S., Tanaka, M., Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s, ACS Biomaterials Science and Engineering, 10.1021/acsbiomaterials.0c01220, 6, 12, 6690-6700, 2020.11.
7.	W. Lee, S. Kobayashi, M. Nagase, Y. Jimbo, I. Saito, Y. Inoue, T. Yambe, M. Sekino, G. G Malliaras, T. Yokota, M. Tanaka, T. Someya, A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors., Science Advances, 10.1126/sciadv.aau2426, 4, 10, eaau2426, 2018.10, [URL], High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young’s modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity..
8.	Shingo Kobayash, Miyuki Wakui, Yukihisa Iwata and Masaru Tanaka, Poly(ω-methoxyalkyl acrylate)s: A nonthrombogenic polymer family with tunable protein adsorption, Biomacromolecules, 10.1021/acs.biomac.7b01247, 18 , 12, 4214-4223, 2017.11.
9.	Sato, Kazuhiro; Kobayashi, Shingo; Kusakari, Miho; Watahiki, Shogo; Oikawa, Masahiko; Hoshiba, Takashi; Tanaka, Masaru, The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues, MACROMOLECULAR BIOSCIENCE, 10.1002/mabi.201500078, 15, 9, 1296-1303, 2015.09.
10.	Henry Martinez, Jihua Zhang, Shingo Kobayashi, Yuewen Xu, Louis M. Pitet, Megan E. Matta, Marc A. Hillmyer, Functionalized regio-regular linear polyethylenes from the ROMP of 3-substituted cyclooctenes, Applied Petrochemical Research, 5, 19-25, 2015.04.
11.	Tanaka Masaru, Sato Kazuhiro, Kitakami Erika, Kobayashi Shingo, Takashi Hoshiba and Kazuki Fukushima, Molecular design of biocompatible soft biomaterials: preparation of bio-interface by intermediate water concept, Molecular Electronics and Bioelectronics, 26, 5-8, 2015.04.
12.	Song Jie, Bringuier Anne, Kobayashi Shingo, INVITED ARTICLE : Adhesion between polyethylenes and different types of polypropylenes, Polymer journal, 10.1038/pj.2012.25, 44, 9, 939-945, 2012.09.
13.	Shingo Kobayashi, Front-line polymer science: Precision Polymer Synthesis via Olefin Metathesis Polymerization, 61, 481-485, 2012.04.
14.	Amino-Functionalized Polyethylene for Enhancing the Adhesion between Polyolefins and Polyurethanes.
15.	Kobayashi, Shingo; Kataoka, Hiroshi; Ishizone, Takashi; Kato, Toshinori; Ono, Tomohiro; Kobukata, Syuji; Arimoto, Kikuo; Ogi, Hiroyuki, Synthesis of well-defined random and block copolymers of 2-(1-adamantyl)-1,3-butadiene with isoprene via anionic polymerization, REACTIVE & FUNCTIONAL POLYMERS, 10.1016/j.reactfunctpolym.2008.12.010, 69, 7, 409-415, 2009.07.
16.	Kobayashi, Shingo; Kataoka, Hiroshi; Ishizone, Takashi, Living anionic polymerization of styrenes containing adamantyl skeletons, Journal of Physics: Conference Series, doi:10.1088/1742-6596/184/1/012017, 184, 012017, 2009.04.

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