Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Shingo Kobayashi Last modified date:2022.09.05

Research Associate Professor / Department of Soft Materials Chemistry / Institute for Materials Chemistry and Engineering

1. Toyokawa, Y., Kobayashi, S., Tsuchiya, H., Shibuya, T., Aoki, M., Sumiya, J., Ooyama, S., Ishizawa, T., Makino, N., Ueno, Y., Tanaka, M., A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition, Materials Science and Engineering C, 10.1016/j.msec.2020.111386, 120, 111386-111386, 2021.01, The adhesion and deformation behavior of proteins at the inner surface of fully covered, self-expandable metallic stents coated with biocompatible polymers, poly(2-methoxyethyl acrylate) (PMEA) and poly(3-methoxypropyl acrylate) (PMC3A), were analyzed. Model bile solution, proteins, and bacteria were used to unravel the inhibitory ability of the polymer coatings. Adsorbance of proteins and adherence of bacteria were both strongly inhibited by the polymer coatings. Circulation tests were performed under clinical conditions using human bile from patients. Adsorption/deformation of proteins and early-stage sludge formation were inhibited on stent surfaces coated with PMEA derivatives. The present study revealed that early-stage biliary sludge formation on PMEA- and PMC3A-coated stents was suppressed due to the strong resistance of the polymers to protein adsorption/deformation, brought about by intermediate water in hydrated polymer coatings, which is not present in conventional coating materials, such as silicone and polyurethane..
2. Kuo, A.-T., Urata, S., Koguchi, R., Sonoda, T., Kobayashi, S., Tanaka, M., Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s, ACS Biomaterials Science and Engineering, 10.1021/acsbiomaterials.0c01220, 6, 12, 6690-6700, 2020.11.
3. W. Lee, S. Kobayashi, M. Nagase, Y. Jimbo, I. Saito, Y. Inoue, T. Yambe, M. Sekino, G. G Malliaras, T. Yokota, M. Tanaka, T. Someya, A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors., Science Advances, 10.1126/sciadv.aau2426, 4, 10, eaau2426, 2018.10, [URL], High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young’s modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity..
4. Shingo Kobayash, Miyuki Wakui, Yukihisa Iwata and Masaru Tanaka, Poly(ω-methoxyalkyl acrylate)s: A nonthrombogenic polymer family with tunable protein adsorption, Biomacromolecules, 10.1021/acs.biomac.7b01247, 18 , 12, 4214-4223, 2017.11.
5. Sato, Kazuhiro; Kobayashi, Shingo; Kusakari, Miho; Watahiki, Shogo; Oikawa, Masahiko; Hoshiba, Takashi; Tanaka, Masaru, The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues, MACROMOLECULAR BIOSCIENCE, 10.1002/mabi.201500078, 15, 9, 1296-1303, 2015.09.
6. Henry Martinez, Jihua Zhang, Shingo Kobayashi, Yuewen Xu, Louis M. Pitet, Megan E. Matta, Marc A. Hillmyer, Functionalized regio-regular linear polyethylenes from the ROMP of 3-substituted cyclooctenes, Applied Petrochemical Research, 5, 19-25, 2015.04.
7. Tanaka Masaru, Sato Kazuhiro, Kitakami Erika, Kobayashi Shingo, Takashi Hoshiba and Kazuki Fukushima, Molecular design of biocompatible soft biomaterials: preparation of bio-interface by intermediate water concept, Molecular Electronics and Bioelectronics, 26, 5-8, 2015.04.
8. Shingo Kobayashi, Front-line polymer science: Precision Polymer Synthesis via Olefin Metathesis Polymerization, 61, 481-485, 2012.04.
9. Kobayashi, Shingo; Kataoka, Hiroshi; Ishizone, Takashi; Kato, Toshinori; Ono, Tomohiro; Kobukata, Syuji; Arimoto, Kikuo; Ogi, Hiroyuki, Synthesis of well-defined random and block copolymers of 2-(1-adamantyl)-1,3-butadiene with isoprene via anionic polymerization, REACTIVE & FUNCTIONAL POLYMERS, 10.1016/j.reactfunctpolym.2008.12.010, 69, 7, 409-415, 2009.07.
10. Kobayashi, Shingo; Kataoka, Hiroshi; Ishizone, Takashi, Living anionic polymerization of styrenes containing adamantyl skeletons, Journal of Physics: Conference Series, doi:10.1088/1742-6596/184/1/012017, 184, 012017, 2009.04.