Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Sumie Makoto Last modified date:2021.08.10

Assistant Professor / Department of Clinical Medicine / Faculty of Medical Sciences

1. Nakayama T, Umehara K, Shirozu K, Sumie M, Karashima Y, Higashi M, Yamaura K., Association between ionized magnesium and postoperative shivering., Journal of Anesthesia, 2021.05.
2. Masami Kimura, Hiroaki Shiokawa, Yuji Karashima, Makoto Sumie, Sumio Hoka, Ken Yamaura, Antinociceptive effect of selective G protein-gated inwardly rectifying K+ channel agonist ML297 in the rat spinal cord., PLoS One, e0239094, 2020.09.
3. Ryohei Miyazaki, Makoto Sumie, Tadashi Kandabashi, Ken Yamaura, Resting pupil size is a predictor of hypotension after induction of general anesthesia, Journal of Anesthesia, 10.1007/s00540-019-02672-y, 33, 5, 594-599, 2019.10, Purpose: Arterial hypotension is a major adverse effect of general anesthesia. Patients with pre-existing autonomic dysfunction are at greater risk of hypotension. This study was performed to examine whether objective measurement of the pupillary light reflex is predictive of intraoperative hypotension. Methods: We studied 79 patients who underwent scheduled surgery under general anesthesia. Patients with severe cardiovascular disease or receiving antihypertensive agents were excluded. The light reflex was measured preoperatively using a portable infrared pupillometer, and the hemodynamic parameters were obtained from the anesthesia records. The patients were divided into two groups according to the development of hypotension: the hypotension and normotension groups. Multivariate logistic regression analysis was performed to determine the pupil parameters predictive of hypotension. Results: Patients in the hypotension group were older and had a greater pupil size or constriction velocity than those in the normotension group. Logistic regression analysis showed that post-induction hypotension was significantly associated with maximum pupil size or constriction velocity after adjustment for age and other clinical variables. Latency of the light reflex and the percent reduction of pupil size were not associated with hypotension. Age was a relatively strong predictor of hypotension; other confounding factors were not associated with hypotension. Conclusion: Measurement of maximum pupil size is useful to identify patients at risk for intraoperative hypotension. The influence of age must be considered during measurement of the pupil response..
4. Makoto Sumie, Hiroaki Shiokawa, Ken Yamaura, Yuji Karashima, Sumio Hoka, Megumu Yoshimura, Direct effect of remifentanil and glycine contained in Ultiva® on nociceptive transmission in the spinal cord
In vivo and slice patch clamp analyses, PloS one, 10.1371/journal.pone.0147339, 11, 1, 2016.01, Background: Ultiva® is commonly administered intravenously for analgesia during general anaesthesia and its main constituent remifentanil is an ultra-short-acting μ-opioid receptor agonist. Ultiva® is not approved for epidural or intrathecal use in clinical practice. Previous studies have reported that Ultiva® provokes opioid-induced hyperalgesia by interacting with spinal dorsal horn neurons. Ultiva® contains glycine, an inhibitory neurotransmitter but also an N-methyl-D-aspartate receptor co-activator. The presence of glycine in the formulation of Ultiva® potentially complicates its effects. We examined how Ultiva1 directly affects nociceptive transmission in the spinal cord. Methods: We made patch-clamp recordings from substantia gelatinosa (SG) neurons in the adult rat spinal dorsal horn in vivo and in spinal cord slices. We perfused Ultiva® onto the SG neurons and analysed its effects on the membrane potentials and synaptic responses activated by noxious mechanical stimuli. Results: Bath application of Ultiva® hyperpolarized membrane potentials under current-clamp conditions and produced an outward current under voltage-clamp conditions. A barrage of excitatory postsynaptic currents (EPSCs) evoked by the stimuli was suppressed by Ultiva®. Miniature EPSCs (mEPSCs) were depressed in frequency but not amplitude. Ultiva®-induced outward currents and suppression of mEPSCs were not inhibited by the μ-opioid receptor antagonist naloxone, but were inhibited by the glycine receptor antagonist strychnine. The Ultiva®-induced currents demonstrated a specific equilibrium potential similar to glycine. Conclusions: We found that intrathecal administration of Ultiva1 to SG neurons hyperpolarized membrane potentials and depressed presynaptic glutamate release predominantly through the activation of glycine receptors. No Ultiva1-induced excitatory effects were observed in SG neurons. Our results suggest different analgesic mechanisms of Ultiva® between intrathecal and intravenous administrations..
5. Katsuyuki Matsushita, Keiko Morikawa, Makoto Sumie, Yoshiro Sakaguchi, Sumio Hoka, Acute upper airway obstruction after extubation due to excessive anteflexion of the neck with occipitocervical fusion, Japanese Journal of Anesthesiology, 62, 2, 168-171, 2013.02, A patient developed upper airway obstruction immediately after tracheal extubation due to excessive anteflexion of the neck with occipitocervical fusion. A 59-year-old woman who had undergone mastectomy 17 years previously was scheduled for occipitocervical fusion for C2 vertebral metastasis. Retroflexion of her neck was restricted. Nasal intubation under sedation was performed using bronchial fiberscopy under fentanyl and propofol anesthesia. Emergence from anesthesia was smooth, and extubation was performed. Immediately after extubation, the patient could not breathe, and manual mask ventilation was impossible. Re-intubation was performed 30 minutes after the extubation. Oral fiberscopy revealed pharyngeal obstruction, and laryngeal edema was not observed. Fixation of her neck in excessive anteflexion was suspected to have caused her dyspnea. Therefore, re-operation was performed, and she was transferred to the intensive care unit under anesthesia. One day postoperatively, extubation was performed successfully with no dyspnea. Fixation of the neck in excessive anteflexion is one of the causes of upper airway obstruction after occipitocervical fusion. We must carefully observe cervical X-ray films to locate the upper airway obstruction, and careful extubation using a tube exchanger is strongly recommended in this operation..
6. Megumi Kimura, Yuji Karashima, Makoto Sumie, Norimitsu Sugioka, Youhei Yamada, Yasuyuki Fujita, Tadashi Kandabashi, Sumio Hoka, Anesthetic management of a cervicoisthmic pregnancy patient undergoing cesarean section, Japanese Journal of Anesthesiology, 61, 4, 390-392, 2012.04, Cervicoisthmic pregnancy is a rare obstetric condition that is potentially dangerous for the pregnant woman due to a high risk of abortion or preterm delivery. We here present a 29-year-old woman with cervicoisthmic pregnancy undergoing cesarean section at full term. Under combined epidural and spinal anesthesia, an infant was delivered alive, and the placenta was preserved without any forces to detach from the uterus. The surgery was completed without massive bleeding. The retained placenta was treated with methotrexate infusion into the uterus from the 6th day as well as uterine artery embolization at the 51th day postpartum. She subsequently required manual removal of the retained placenta under combined epidural and spinal anesthesia with only small bleeding. She was discharged from our hospital uneventfully. Meticulous preparation for massive bleeding and long-term treatment of the retained placenta are important in the perioperative management for cesarean section of a full term patient with cervicoisthmic pregnancy..
7. Makoto Sumie, Kouhei Toyama, Tomoka Yokoo-Matsuoka, Ken Yamaura, Sumio Hoka, Keiko Morikawa, Chihiro Takamatsu, Inadvertent bleeding in an infant after inguinal hernioplasty leads to diagnosis of hemophilia B, Journal of Anesthesia, 10.1007/s00540-011-1290-5, 26, 2, 299-300, 2012.04.