| 1. |
Yusuke Nakatsu, Yasuka Matsunaga, Mikako Nakanishi, Takeshi Yamamotoya, Tomomi Sano, Takashi Kanematsu, Tomoichiro Asano, Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity, Biochemical and Biophysical Research Communications, 150001, 2024.04. |
| 2. |
Li R, Sano T, Mizokami A, Fukuda T, Shinjo T, Iwashita M, Yamashita A, Sanui T, Nakatsu Y, Sotomaru Y, Asano T, Kanematsu T, Nishimura F, miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation., Arch Biochem Biophys, 10.1016/j.abb.2022.109501., 2023.01. |
| 3. |
Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F., miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress, Frontiers in Cell and Developmental Biology, 2022.12. |
| 4. |
Yuki Nishimura, Misaki Iwashita, Masato Hayashi, Takanori Shinjo, Yukari Watanabe, Tatsuro Zeze, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomomi Sano, Tomoichiro Asano & Fusanori Nishimura , XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis, Acta Diabetologica, 10.1007/s00592-022-01930-y, 2022.07. |
| 5. |
Mori K, Mizokami A, Sano T, Mukai S, Hiura F, Ayukawa Y, Koyano K, Kanematsu T, Jimi E., RANKL elevation activates the NIK/NF-κB pathway, inducing obesity in ovariectomized mice., J Endocrinol., 10.1530/JOE-21-0424, 254, 1, 27-36, 2022.05. |
| 6. |
Yamashita A, Sano T, Iwashita M, Nishimura F., A Case Report of Improved Palmoplantar Pustulosis following Periodontal Treatment and Possible Association with Diminished Systemic Subclinical Inflammation, Case Rep Dermatol Med., 10.1155/2021/5548760, 2021.10. |
| 7. |
Hayashi M, Iwashita M, Nishimura Y, Shinjo T, Sano T, Yamashita A, Fukuda T, Sanui T, Asano T, Nishimura F., Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain., BMJ Open Diabetes Res Care., 10.1136/bmjdrc-2020-001871., 9, 1, e001871, 2021.05. |
| 8. |
Maetani Y, Asano S, Mizokami A, Yamawaki Y, Sano T, Hirata M, Irifune M, Kanematsu T., Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and suppresses tumor growth in a xenograft mouse model, Biochem Biophys Res Commun. , 2021.05. |
| 9. |
Mukai S, Mizokami A, Otani T, Sano T, Matsuda M, Chishaki S, Gao J, Kawakubo-Yasukochi T, Tang R, Kanematsu T, Takeuchi H, Jimi E, Hirata M., Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis., J Biol Chem., 2021.01. |
| 10. |
Rehab Alshargabi, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Tomomi Sano, Yuki Nishimura, Masato Hayashi, Tatsuro Zeze, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura, SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism, Biochem Biophys Res Commun, 10.1016/j.bbrc.2020.09.129, doi: 10.1016/j.bbrc.2020.09.129, 2020.10. |
| 11. |
Alshargabi R, Sano T, Yamashita A, Takano A, Sanada T, Iwashita M, Shinjo T, Fukuda T, Sanui T, Kishida S, Nishimura F., SPOCK1 Is a Novel Inducer of Epithelial to Mesenchymal Transition in Drug-Induced Gingival Overgrowth., Sci Rep., 10, 1, 9785, 2020.07. |
| 12. |
Taiki Sanada, Tomomi Sano, Yusuke Sotomaru, Rehab Alshargabi, Yosuke Yamawaki, Akiko Yamashita, Hiroaki Matsunaga, Misaki Iwashita, Takanori Shinjo, Takashi Kanematsu, Tomoichiro Asano, Fusanori Nishimura, Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues, Biochemistry and Biophysics Reports, 10.1016/j.bbrep.2020.100757, 22, 2020.07, MicroRNA (miRNA) plays an important role in diverse cellular biological processes such as inflammatory response, differentiation and proliferation, and carcinogenesis. miR-146a has been suggested as a negative regulator of the inflammatory reaction. Although, it has been reported as expressed in inflamed adipose and periodontal tissues, however, miR-146a's inhibitory effects against inflammatory response in both the tissues, are not well understood. Therefore, in this study, the inhibitory effects of miR-146a on both adipose and periodontal inflammation, was investigated. In vitro study has revealed that miR-146a transfection into either adipocytes or gingival fibroblasts, has resulted in a reduced cytokine gene expression, observed on co-culturing the cells with macrophages in the presence of lipopolysaccharides (LPS), in comparison to the control miRNA transfected. Similarly, miR-146a transfection into macrophages resulted in a reduced expression of TNF-α gene and protein in response to LPS stimulation. In vivo study revealed that a continuous intravenous miR-146a administration into mice via tail vein, protected the mice from developing high-fat diet-induced obesity and the inflammatory cytokine gene expression was down-regulated in both adipose and periodontal tissues. miR-146a appeared to be induced by macrophage-derived inflammatory signals such as TNF-α by negative feed-back mechanism, and it suppressed inflammatory reaction in both adipose and periodontal tissues. Therefore, miR-146a could be suggested as a potential therapeutic molecule and as a common inflammatory regulator for both obesity-induced diabetes and related periodontal diseases.. |
| 13. |
Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata-Tsuchiya S, Nakao Y, Sano T, Yamashita A, Yamada S, Ohta K, Shiba H, Nishimura F., Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles., Sci Rep., 2019.03. |
| 14. |
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T., Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16., Cell Rep., 2019.03. |
| 15. |
新城 尊徳, 岩下 未咲, 山下 明子, 佐野 朋美, 鶴田 満大, 松永 紘明, 讃井 彰一, 浅野 知一郎, 西村 英紀, IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes., Biochemical and Biophysical Research Communications, 477, 2, 241-246, 2016.08. |
