Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Masaki Kawamata Last modified date:2022.06.20

Assistant Professor / Division of Organogenesis and Regeneration / Department of Molecular and Cellular Biology / Medical Institute of Bioregulation

1. Masaki Kawamata, Atsushi SUZUKI, Cell fate modification toward the hepatic lineage by extrinsic factors., J Biochem, 2017.06, The lineage of a somatic cell can be altered by targeting its signaling networks with small molecules and/or genetically altering the expression of key transcription factors. Depending on the combination of factors, fibroblasts can be fully reprogrammed into induced pluripotent stem (iPS) cells or directly converted into specific cell lineages, bypassing the pluripotent state. The generation of defined target cells will enormously benefit patients who require cell transplantation therapy. In the decade since iPS cells were first generated, many cell types have been induced from fibroblasts by direct conversion, including hepatocytes. Converted hepatocyte-like cells have been shown to repopulate liver tissues after transplantation in mouse liver disease models, suggesting promise for future application in humans. Thus, to realize safe and efficient cell transplantation therapy, various methods for generating hepatocyte-like cells are being developed. In this review, we summarize the current methods for the generation of hepatocyte-like cells via cell fate modification using extrinsic factors..
2. Kazushi Kawaharada, Masaki Kawamata, Takahiro Ochiya, Rat embryonic stem cells create new era in development of genetically manipulated rat models, World J Stem Cells, 2015.08.
3. Takeshi Katsuda, Shingo Ikeda, Yusuke Yoshioka, Nobuyoshi Kosaka, Masaki Kawamata, Takahiro Ochiya, Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application, Biol Chem, 2014.04.
4. Masaki Kawamata, Takahiro Ochiya, Gene-manipulated embryonic stem cells for rat transgenesis, Cell Mol Life Sci, 2011.06.
5. Masaki Kawamata, Takahiro Ochiya, Establishment of embryonic stem cells and generation of genetically modified rats, InTech, 2011.01.
6. Masaki Kawamata, Takahiro Ochiya, Establishment of embryonic stem cells from rat blastocysts, Methods Mol Biol, 2010.01.
7. Katsuhiko Nishimori, Yuki Takayanagi, Masahide Yoshida, Yoshiyuki Kasahara, Larry J. Young, Masaki Kawamata, New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance, Prog Brain Res, 2008.01.