| 1. |
Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Ryo Somehara, Masayuki Sasaki2, Hiroshi Honda1
, Predicting Efficacy of Radium-223 Dichrolide (223RaCl2) therapy in Bone-metastatic Castration-resistant Prostate Cancer
Using F-18 Sodium Fluoride (18F-NaF) PET/CT
, SNMMI 2019 Annual Meeting, 2019.06. |
| 2. |
Yoshiyuki Kitamura, Shingo Baba, Takuro Isoda, Ryo Somehara, Keiichiro Tahara, Akifumi Yamada, Masayuki Sasaki, Hiroshi Honda, Assessment of the effect of Urinary excretion rate of 18F-Sodium fluoride on the SUV of NaF PET/CT., 第77回日本医学放射線学会総会, 2018.04, Objective: A large amount of injected 18F-Sodium fluoride (NaF) is thought to be excreted by kidney. The effect of excretion rate of NaF on SUV is not well known in NaF PET/CT. We evaluated the relationship between urinary excretion rate of NaF and bone SUV in normal volunteers.
Materials and Methods: Whole body PET/CT scan was performed 30 and 70 min after the injection with a mean dose of 58 MBq of NaF in five male volunteers (age:32-48) with normal renal function. The SUV of all thoracolumbar vertebras and blood pool (aortic arch and left ventricle) were measured in both scans. Increase rates of SUV between first and second scan were also calculated. Urinary excretion rate of each volunteer was calculated using direct measurement of radioactivity of urine which acquired after the first scan and total injected dose. Correlation of excretion rate and SUV were evaluated.
Results: Significant variation was seen in urinary excretion rate (25.6-77.2 % ; mean: 52.9%, coefficient of variation: 0.40). No significant correlation was seen between urinary excretion rate and SUV (R2=0.02, p=0.17) nor increased rate (R2=0.06, p<0.05) in thoracolumbar vertebras. Inverse correlation was seen between urinary excretion rate and increased rate in blood pool(R2=0.53, p=0.16).
Conclusion: The bone SUV in NaF PET/CT is stable despite urinary excretion rate of NaF which have a significant individual difference. On the other hand, uptake of blood pool is susceptible to excretion rate. So attention is needed when we use it as background reference.
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| 3. |
磯田 拓郎, 馬場 眞吾, 丸岡 保博, 北村 宜之, 田原 圭一郎, 佐々木 雅之, 本田 浩, Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer, 63th Annual Meeting, Society of Nuclear Medicine, 2016.06. |
| 4. |
北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 田原 圭一郎, 佐々木 雅之, 西江 昭弘, 本田 浩, Usefulness of Semi-quantitative Analysis in I-123 Metaiodobenzylguanidine Scintigraphy for Differentiation of Pheochromocytoma and Cortical Adenoma, 第75回日本医学放射線学総会, 2016.04. |
