Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Nishiyama Kei Last modified date:2021.08.05

Assistant Professor / Pediatrics / Kyushu University Hospital

1. Kurokawa M, Nishiyama K, Oba U, Eguchi K, Ishimura M, Koga Y, Ohga S, Risk factors for acute kidney injury in pediatric patients receiving allogenic hematopoietic cell transplantation., 17th China-Japan-Korea Pediatric Nephrology Seminar 2019, 2019.04.
2. Imai T, Nishiyama K, Murata K, Ohga S:, Involvement of cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis., 18th Congress of the International Pediatric Nephrology Association., 2019.10.
3. Kei Nishiyama, Yoshitsugu Kaku, Takashi Imai, Hidetoshi Takada, Urinary liver-type fatty acid binding protein (L-FABP): Potent prognostic factor for congenital anomalies of kidney and urinary tract (CAKUT), The 14th China-Japan-Korea Pediatric Nephrology Seminar, 2016.06, Backgrounds: Liver-type fatty acid binding protein (L-FABP) is excreted from the proximal tubules into urine in response to ischemia and oxidative stress. Applying the character, urinary L-FABP has been used for early biomarker of acute kidney injury (AKI). However, in chronic kidney disease (CKD), the significance is not obvious. So we evaluated the clinical usefulness in children with congenital anomalies of kidney and urinary tract (CAKUT), which were the most common cause of pediatric CKD.
Methods: In 2015, we examined urinary L-FABP level in 29 children with CAKUT. Clinical data (age, gender, height, Cr, T-chol, TG, Glu, uTP, uCr, uBMG) were obtained from medical records. The correlation between uL-FABP/Cr and each variables and the strength of the effect of each variables on uL-FABP/Cr were analyzed. Using a cut-off level (uL-FABP/Cr ≤ 8.4 µg/gCr), we divided patients into two groups: higher (H) group and lower (L) group. We compered eGFR and ∆eGFR between these two groups.
Results: Median age at the examination was 8.4 (range: 2-18) years old and male/female ratio was 14/15. There were strong positive correlation between uL-FABP/Cr and uBMG/Cr (r2=0.984562, p<0.0001) and weak negative correlation between uL-FABP/Cr and eGFR (r2=0.458441, p=0.0021). Multiple regression analysis revealed that uL-FABP/Cr was correlated with uBMG/Cr, eGFR with significance. In H and L group, median eGFR was 37.0 (11.9-77.5) ml/min/1.73m2 and 94.2 (64.0-170.3) ml/min/1.73m2, respectively (p=0.0001). The decline rate of eGFR per year of H group was more serious (-15.5%) than of L group (-1.4%, p=0.022). Estimated GFR of H group was considered to significantly earlier deteriorate than of L group.
Conclusion: Based on these results, we speculate that uL-FABP/Cr indicates current kidney function and can expect at the same time future renal function degeneracy. Further study with more patients and longer observation period is needed to establish the clinical usefulness of uL-FABP in pediatric CAKUT..