Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Keisuke Tomohara Last modified date:2019.11.11

Assistant Professor / Division for Experimental Natural Science / Faculty of Arts and Science

1. Keisuke Tomohara*, Naoto Hasegawa, Isao Adachi, Yoshikazu Horino, Takeru Nose*., Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay., Bioorg. Med. Chem. Lett., In press, 2019.11.
2. Keisuke Tomohara*, Isao Adachi, Yoshikazu Horino, Hitoshi Kesamaru, Hitoshi Abe, Keitaro Suyama, Takeru Nose*., DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors., ACS Med. Chem. Lett., 10.1021/acsmedchemlett.9b00093, 10, 923-928, 2019.05.
3. Keisuke Tomohara,*, Isao Adachi, Hitoshi Kesamaru, Takeru Nose.*, Mechanistic Characterization of α-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, Peptide Science 2018: Proceedings of the 10th International Peptide Symposium / The 55th Japanese Peptide Symposium, 107-108, 2019.03.
4. Yoshikazu Horino*, Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe., Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, Org. Lett., 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
5. Keisuke Tomohara*, Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi*., Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, Tetrahedron Lett., 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08.
6. Keisuke Tomohara*, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi*., Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, Bioorg. Med. Chem. Lett., 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.
7. Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata*., Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates, Chem. Pharm. Bull., 64, 7, 899-906, 2016.07.
8. Keisuke Tomohara*, Tomohiro Ito, Saika Onikata, Kota Furusawa, Atsushi Kato, Isao Adachi*., Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions., Bioorg. Med. Chem. Lett., 10.1016/j.bmcl.2016.04.082, 26, 13, 3153-3157, 2016.07.
9. Keisuke Tomohara*, Tomohiro Ito, Naoto Hasegawa, Atsushi Kato, Isao Adachi*., Direct chemical derivatization of natural plant extract: straightforward synthesis of natural plant-like hydantoin, Tetrahedron Lett., 10.1016/j.tetlet.2016.01.054, 57, 8, 924-927, 2016.02.
10. Keisuke Tomohara, Tomoyuki Yoshimura, Ryuichi Hyakutake, Pan Yang, Takeo Kawabata*., Asymmetric alpha-Arylation of Amino Acid Derivatives by Clayden Rearrangement of Ester Enolates via Memory of Chirality., J. Am. Chem. Soc., 10.1021/ja406653n, 135, 36, 13294-13297, 2013.09.
11. Tomoyuki Yoshimura, Keisuke Tomohara, Takeo Kawabata*., Asymmetric Induction via Short-Lived Chiral Enolates with a Chiral C-O Axis., J. Am. Chem. Soc., 10.1021/ja4018122, 135, 19, 7102-7105, 2013.05.
12. Tomoyuki Yoshimura, Masatoshi Takuwa, Keisuke Tomohara, Makoto Uyama, Kazuhiro Hayashi, Pan Yang, Ryuichi Hyakutake, Takahiro Sasamori, Norihiro Tokitoh, Takeo Kawabata*., Protonation-Assisted Conjugate Addition of Axially Chiral Enolates: Asymmetric Synthesis of Multisubstituted beta-Lactams from alpha-Amino Acids., Chem. Eur. J., 10.1002/chem.201201339, 18, 48, 15330-15336, 2012.11.