| 1. |
岸田良, 林幸壱朗, 土谷享, 島袋将弥, 石川邦夫, 炭酸アパタイトセメントの創製およびin vivo骨伝導性評価, 日本歯科理工学会第79回学術講演会, 2022.05, The composition of apatite cements primarily affects the osteoconductivity, while chemical alterations can negatively affect the mechanical strength. Herein, an apatite cement forming carbonate apatite (CO3Ap) was fabricated to improve the osteoconductivity without sacrificing the mechanical performance. A mixed powder of ground α-tricalcium phosphate (α-TCP) and larger-sized vaterite showed a setting reaction under 100% humidity, and converted to CO3Ap with 5.6 MPa of diametral tensile strength after 7 day. In a rabbit femur defect, the CO3Ap cement showed a higher bone-to-material contact ratio and larger material deformation than a hydroxyapatite cement, indicating an improved osteoconductivity.. |
| 2. |
岸田 良, Maab Elsheikh, 林幸壱朗, 土谷 享, 石川邦夫, マクロ-ミクロ気孔を有する骨様3次元多孔体の創製 -炭酸アパタイト骨補填材の高機能化を目指して-, 日本歯科理工学会 第74回学術講演会, 2019.10, Osteoconduction and bioresorption of bone substitute materials depend on the composition and the porous structure. Bone apatite (carbonate apatite) can be fabricated via calcium carbonate as a precursor, and is both osteoconductive and bioresorbable. The present study aimed to introduce macro/micro porous structures into calcium carbonate. We made use of setting of gypsum granules, that interconnects to each other, and of crystal morphology changes during phase transition to calcium carbonate, realizing macro- and microporous structures, respectively. Although the carbonation remarkably weakens the mechanical strength, we found that this weakening can be avoided by high temperature heating prior to carbonation.. |
| 3. |
Kunio Ishikawa, Koichiro Hayashi, Akira Tsuchiya, Ryo Kishida, Vertical bone augmentation using carbonate apatite bone substitute, Society for Biomaterials Annual Meeting and Exposition 2019, 2019.06. |
| 4. |
岸田良、林幸壱朗、石川邦夫, 石膏顆粒の連結硬化体を前駆物質とする炭酸アパタイト多孔体の作製・物性評価
, 生体材料・力学研究会, 2019.06. |
| 5. |
岸田良, Tya Indah Arifta, 石川邦夫, α型リン酸三カルシウム球の硬化による低結晶性ハイドロキシアパタイト多孔体の作製, 第40回日本バイオマテリアル学会, 2018.11. |
