Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Mitsuru Watanabe Last modified date:2022.07.26

Assistant Professor / Neurology / Kyushu University Hospital

1. Mitsuru Watanabe, Ryo Yamasaki, Jun-ichi Kira, Relationship between Th1 cells and astrocytic connexin 43 gap junctions in multiple sclerosis, Clinical and Experimental Neuroimmunology, 10.1111/cen3.12384, 2017.05.
2. Mitsuru Watanabe, Takayuki Kondo, Autoantibodies to neural antigens in CNS demyelinating disorders, Current Neurobiology, 10.4172/0975-9042.000108, 2016.01, The relationship between central nervous system demyelinating disorders (CNSDDs) and anti-neural antibodies (Abs), with the exception of anti-aquaporin 4 (AQP4) Abs, is not well understood. We previously screened for a variety of anti-neural Abs in the sera of Japanese patients with CNSDDs and found three patients with anti-N-methyl-d-aspartate receptor (NMDAR) Abs and three patients with anti-contactin-associated protein 2 (CASPR2) Abs. These Abs have not yet been considered as causing CNSDDs. Here, we describe CNSDD patients with these autoantibodies and discuss whether these Abs are pathogenic or not, based on the clinical presentation and literature documentation. Moreover, we propose points to which attention should be paid when dealing with patients with CNSDDs in a clinical setting..