Kyushu University [Makoto Yoritate (Assistant Professor) Faculty of Pharmaceutical Sciences, Department of Chemo-Pharmaceutical Sciences]

Makoto Yoritate

Last modified date：2022.06.29

Assistant Professor / Go Hirai Group / Department of Chemo-Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences

Reports

Takaaki Sato, Makoto Yoritate, Hayato Tajima, Noritaka Chida, Total synthesis of complex alkaloids by nucleophilic addition to amides, Organic and Biomolecular Chemistry, 10.1039/c8ob00733k, 2018.01, Nucleophilic addition to amides has been recognized as a promising transformation for total synthesis of complex alkaloids. Amides can accept two different organometallic reagents through the nucleophilic addition, which enables it to serve as a stable surrogate of multi-substituted amines. However, the nucleophilic addition has been overlooked for a long time due to three main reasons: low electrophilicity of amide carbonyls, potential hydrolysis of the reaction intermediate and excess addition of an organometallic reagent. This mini review focuses on the recent progress of total synthesis of complex alkaloids based on the nucleophilic additions to N-alkoxyamides, tertiary amides and secondary amides..

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