Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Hieda Michinari Last modified date:2021.12.01

Assistant Professor / Faculty of Medical Sciences

1. Hieda M, Sarma S, Hearon CM Jr, MacNamara JP, Dias KA, Samels M, Palmer D, Livingston S, Morris M, Levine BD. , One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction, Circulation, 10.1161/CIRCULATIONAHA.121.054117, 144, 12, 934-946, 2021.09.
2. Tran T, Muralidhar A, Hunter K, Buchanan C, Coe G, Hieda M, Tompkins C, Zipse M, Spotts MJ, Laing SG, Fosmark K, Hoffman J, Ambardekar AV, Wolfel EE, Lawley J, Levine B, Kohrt WM, Pal J, Cornwell WK 3rd., Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices., J Heart Lung Transplant, 10.1016/j.healun.2020.11.009, 40, 2, 128-137, 2021.02, BACKGROUND
Patients with continuous-flow left ventricular assist devices (CF-LVADs) experience limitations in functional capacity and frequently, right ventricular (RV) dysfunction. We sought to characterize RV function in the context of global cardiopulmonary performance during exercise in this population.

A total of 26 patients with CF-LVAD (aged 58 ± 11 years, 23 males) completed a hemodynamic assessment with either conductance catheters (Group 1, n = 13) inserted into the right ventricle to generate RV pressure‒volume loops or traditional Swan‒Ganz catheters (Group 2, n = 13) during invasive cardiopulmonary exercise testing. Hemodynamics were collected at rest, 2 sub-maximal levels of exercise, and peak effort. Breath-by-breath gas exchange parameters were collected by indirect calorimetry. Group 1 participants also completed an invasive ramp test during supine rest to determine the impact of varying levels of CF-LVAD support on RV function.

In Group 1, pump speed modulations minimally influenced RV function. During upright exercise, there were modest increases in RV contractility during sub-maximal exercise, but there were no appreciable increases at peak effort. Ventricular‒arterial coupling was preserved throughout the exercise. In Group 2, there were large increases in pulmonary arterial, left-sided filling, and right-sided filling pressures during sub-maximal and peak exercises. Among all participants, the cardiac output‒oxygen uptake relationship was preserved at 5.8:1. Ventilatory efficiency was severely abnormal at 42.3 ± 11.6.

Patients with CF-LVAD suffer from limited RV contractile reserve; marked elevations in pulmonary, left-sided filling, and right-sided filling pressures during exercise; and severe ventilatory inefficiency. These findings explain mechanisms for persistent reductions in functional capacity in this patient population..
3. Hardin EA, Stoller D, Lawley J, Howden EJ, Hieda M, Pawelczyk J, Jarvis S, Prisk K, Sarma S, Levine BD, Noninvasive Assessment of Cardiac Output: Accuracy and Precision of the Closed-Circuit Acetylene Rebreathing Technique for Cardiac Output Measurement., J Am Heart Assoc, 10.1161/JAHA.120.015794, 9, 17, e015794-e015794, 2020.09.
4. Cramer MN, Hieda M, Huang M, Moralez G, Crandall CG, Dietary nitrate supplementation does not influence thermoregulatory or cardiovascular strain in older individuals during severe ambient heat stress., Exp Physiol., 10.1113/EP088834, 2020, 1-12, 2020.08.
5. Mantha Y, Harada R, Hieda M, Assaf A, Tatiraju U, Feldman M and Kawalsky D, Masson Tumor in the Left Atrial Appendage Presenting as Cardioembolic Cerebral Infarction., JACC: Case Reports, 10.1016/j.jaccas.2020.05.044, 1-5, 2020.07.
6. Hieda M, Esposito G, Bossone E, Novel Clinical and Pathophysiologic Concepts in Cardiovascular Emergencies., Heart Fail Clin., 10.1016/j.hfc.2020.04.001, 16, 3, XI-XII, 2020.07.
7. Rao P, Katz D, Hieda M, Sabe M, How to Manage Temporary Mechanical Circulatory Support Devices in the Critical Care Setting: Translating Physiology to the Bedside., Heart Fail Clin., 10.1016/j.hfc.2020.03.001, 16, 3, 283-293, 2020.07.
8. Hieda M, Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure., Heart Fail Clin., 10.1016/j.hfc.2020.02.005, 16, 3, 271-282, 2020.07.
9. Hieda M, Goto Y, Cardiac Mechanoenergetics in Patients with Acute Myocardial Infarction: From Pressure-Volume Loop Diagram Related to Cardiac Oxygen Consumption., Heart Fail Clin., 10.1016/j.hfc.2020.02.002, 16, 3, 255-269, 2020.07.
10. Moghadam N, Hieda M, Ramey L, Levine BD, Guilliod R., Hyperbaric Oxygen Therapy in Sports Musculoskeletal Injuries., Med Sci Sports Exerc, 10.1249/MSS.0000000000002257, 52, 6, 1420-1426, 2020.06.
11. Maruyama T, Arita T, Yokoyama T, Hieda M, Fukata M, Fujino T, Mawatari S, Akashi K, Impaired deformability and association with density distribution of erythrocytes in patients with type 2 diabetes mellitus under treatment., Clin Hemorheol Microcirc, 10.3233/CH-200873, 1-11, 2020.05.
12. Hieda M, Esposito G, Bossone E, The Latest Clinical Understandings and Theory of the Cardiovascular Systems for Cardiovascular Emergencies and Their Management., Heart Fail Clin, 10.1016/j.hfc.2020.01.001, 16, 2, Ⅸ-Ⅹ, 2020.04.
13. Mantha Y, Harada R, Hieda M, Management of Common Cardiovascular Emergencies in Critically Ill Patients., Heart Fail Clin, 10.1016/j.hfc.2020.01.001, 16, 2, 153-166, 2020.04.
14. Harada R, Mantha Y, Hieda M, Back to Basics: Key Physical Examinations and
Theories in Patients with Heart Failure., Heart Fail Clin, 10.1016/j.hfc.2020.01.001, 16, 2, 139-151, 2020.04.
15. Mantha Y, Feldman M, Assaf A, Harada R, Musselman D, Hieda M, Kawalsky D, Anomalous Origin of Right Coronary Artery from Pulmonary Artery (ARCAPA) in a Middle- Aged Woman., JACC case report, 10.1016/j.jaccas.2020.01.008, 2, 3, 464-467, 2020.03.
16. Mada PK, Malus EM, Parvathaneni A, Chen B, Castano B, Adley B, Moore M, Hieda M,, Impact of Treatment with Direct Acting Antiviral Drugs on Glycemic Control in Patients with Hepatitis C and Diabetes Mellitus., Clin Hemorheol Microcirc, 10.1155/2020/6438753. eCollection 2020., 2020, e1-e6, 2020.01.
17. Hieda M, Satyam S, Hearon Jr. C, Dias K, Martinez J, Samels M, Everding B, Palmer D, Livingston S, Morris M, Howden E, Levine BD, Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection., Circulation, 10.1161/CIRCULATIONAHA.119.040332, 141, 2, 115-123, 2020.01.
18. Hearon Jr. C, Ph.D; Sarma S, Dias K, Hieda M, Levine DB, Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction., Heart, 10.1136/heartjnl-2019-314797, 105, 20, 1552-1558, 2019.10.
19. Aiad N, Hearon C, Hieda M, Dias K; Levine DB, and Sarma S, Mechanisms of Left Atrial Enlargement in Obesity - The Influence of Left Ventricular Remodeling., American Journal of Cardiology, 10.1016/j.amjcard.2019.04.043, 124, 3, 442-447, 2019.08.
20. Hieda M, Yoo JK, Badrov BM, Parker SR, Anderson HE, Wiblin LJ, Kawalsky J, North SC, Suris A, and Fu Q, Reduced Left Ventricular Diastolic Function in Women with Post-Traumatic Stress Disorder., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 10.1152/ajpregu.00002.2019, 317, 1, 108-112, 2019.07.
21. McNamara DA, Aiad N, Howden E, Hieda M, Link MS, Everding B, Palmer D, Samels M, Ng J, Adams-Huet B, Mildred O, Sarma S, and Levine BD, Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity Exercise Training in Sedentary Middle-Aged Adults., Circulation, 10.1161/CIRCULATIONAHA.118.037615, 139, 12, 1507-1516, 2019.03.
22. Samuel TJ, Nelson MD, Nasirian A, Jaffery M, Moralez G, Romero SA, Cramer MN, Huang M, Kouda K, Hieda M, Sarma S and Crandall CG, Cardiac Structure and Function in Well-Healed Burn Survivors., Journal of Burn Care & Research, 10.1093/jbcr/irz008, 40, 2, 235-241, 2019.02.
23. Badrov BM, Park S, Yoo JK, Hieda M, Okada Y, Jarvis SS, Stickford AS, Best SA, Nelson DB, and Fu Q, MD, Role of Corin in blood pressure regulation in normotensive and hypertensive pregnancy: a prospective study., Hypertension, 10.1161/HYPERTENSIONAHA.118.12137, 73, 2, 432-439, 2019.02.
24. Hieda M, Howden E, Sarma S, Cornwell W, Lawley J, Tarumi T, Palmer D, Samels M, Everding B, Livingston S, Fu Q, Zhang R, and Levine BD, The Impact of 2-Years of High Intensity Exercise Training on a Model of Integrated Cardiovascular Regulation., Journal of Physiology, 10.1113/JP276676, 597, 2, 419-429, 2019.01.
25. Hieda M, Howden E, Shibata S, Fujimoto N, Bhella PS, Hastings JL, Tarumi T, Satyam S, Fu Q, Zhang R, Levine BD, Impact of Lifelong Exercise Training Dose on Ventricular-Arterial Coupling., Circulation, 10.1161/CIRCULATIONAHA.118.035116, 138, 23, 2638-2647, 2018.12.
26. Hieda M, Yoo JK, Sun D, Okada Y, Parker R, Roberts-Reeves M, Adams-Huet B, Nelson D, Levine DB, and Fu Q, Time Course of Changes in Maternal Left Ventricular Function during Subsequent Pregnancy in Women with a History of Gestational Hypertensive Disorders., American Journal of Physiology-Regulatory, Integrativeand and Comparative Physiology, 10.1152/ajpregu.00040.2018, 315, 4, 587-594, 2018.10.
27. Opondo MA, Aiad N, Cain MA, Sarma S, Howden E, Stoller DA, Ng J, van Rijckevorsel P, Hieda M, Tarumi T, Palmer MD, Levine BD, Does High Intensity Endurance Training Increase the Risk of Atrial Fibrillation? A Longitudinal Study of Left Atrial Structure and Function., Circulation: Arrhythmia and Electrophysiology, 10.1161/CIRCEP.117.005598., 11, 5, e005598, 2018.05.
28. Yoo JK, Okada Y, Best SA, Parker RS, Hieda M, Levine BD, Fu Q, Left ventricular remodeling and arterial afterload in older women with uncontrolled and controlled hypertension., Menopause, 10.1097/GME.0000000000001046, 25, 5, 554-562, 2018.05.
29. Hieda M, Parker J, Rajabi T, Fujimoto N, Bhella PS, Prasad A, Hastings JL, Sarma S, Levine BD, Left Ventricular Volume-Time Relation in Patients With Heart Failure With Preserved Ejection Fraction., Am J Cardiol, 10.1016/j.amjcard.2017.11.033, 121, 5, 609-614, 2018.03.
30. Howden E, Carrick-Ranson G, Sarma S, Hieda M, Fujimoto N, Benjamin D. Levine, Effect of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function., Medicine & Science in Sports & Exercise, 10.1249/MSS.0000000000001464, 50, 3, 494-501, 2018.03.
31. Hieda M; Howden E; Shibata S; Tarumi T; Lawley J; Hearon C Jr.; Palmer D; Fu Q; Zhang R; Sarma S; Benjamin D. Levine, Pre-load Corrected Dynamic Starling Mechanism in Patients with Heart Failure with Preserved Ejection Fraction., Journal of Applied Physiology, 10.1152/japplphysiol.00718.2017, 124, 1, 76-82, 2018.01.
32. Ogoh S, Moralez G, Washio T, Sarma S, Hieda M, Romero S, Cramer M, Shibasaki M, and Crandall C, Effect of increases in cardiac contractility on cerebral blood flow in humans., American Journal of Physiology Heart and Circulatory Physiology, 10.1152/ajpheart.00287.2017, 313, 6, H1155-H1161, 2017.12.
33. Watanabe T, Seguchi O, Nishimura K, Fujita T, Murata Y, Yanase M, Sato T, Sunami H, Nakajima S, Hisamatsu E, Sato T, Kuroda K, Hieda M, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T, Suppressive effects of conversion from mycophenolate mofetil to everolimus for the development of cardiac allograft vasculopathy in maintenance of heart transplant recipients., Int J Cardiol, 10.1016/j.ijcard.2015.10.082, 203, 307-314, 2016.01.
34. Hieda M, Seguchi O, Mutara Y, Sunami H, Sato T, Yanase M, Hiroki H, Fujita T, Nakatani T, Acute response test to adaptive servo-ventilation, a possible modality to assessing the reversibility of pulmonary vascular resistance., J Artif Organs, 10.1007/s10047-015-0833-1, 18, 3, 280-283, 2015.09.
35. Hieda M, Sata M, Nakatani T, The Importance of the Management of Infectious Complications for Patients with Left Ventricular Assist Device., Healthcare, 10.3390/healthcare3030750, 3, 3, 750-756, 2015.08.
36. Sato T, Seguchi O, Iwashima Y, Yanase M, Nakajima S, Hieda M, Watanabe T, Sunami H, Murata Y, Hata H, Fujita T, Kobayashi J, Nakatani T, Serum Brain Natriuretic Peptide Concentration 60 Days after Surgery as a Predictor of Long-term Prognosis in Patients Implanted with a Left Ventricular Assist Device., ASAIO J, 10.1097/MAT.0000000000000237, 61, 4, 373-378, 2015.07.
37. Nakajima S, Seguchi O, Murata Y, Fujita T, Hata H, Yamane T, Hieda ;, Watanabe T, Sato T, Sunami H, Yanase M, Kobayashi J, Nakatani T, Left coronary artery occlusion caused by a large thrombus on the left coronary cusp in a patient with a continuous-flow ventricular assist device., J Artif Organs, 10.1007/s10047-014-0758-0, 17, 2, 197-201, 2014.06.
38. Hieda M, Sata M, Seguchi O, Yanase M, Murata Y, Sato T, Sunami H, Nakajima S, Watanabe T, Hori Y, Wada K, Hata H, Fujita T, Kobayashi J, Nakatani T, Importance of Early Appropriate Intervention including Antibiotics and Wound care for Device-related Infection in Patients with Left Ventricular Assist Device., Transplant Proc, 10.1016/j.transproceed.2013.11.106, 46, 3, 907-910, 2014.04.
39. Suwa H, Seguchi O, Fujita T, Murata Y, Hieda M, Watanabe T, Sato T, Sunami H, Yanase M, Hata H, Nakatani T, Paracorporeal ventricular assist device as a bridge to transplant candidacy in the era of implantable continuous-flow ventricular assist device., J Artif Organs, 10.1007/s10047-013-0731-3, 17, 1, 16-22, 2014.03.
40. Sato T, Seguchi O, Morikawa N, Hieda M, Watanabe T, Sunami H, Murata Y, Yanase M, Hata H, Fujita T, Nakatani T, A heart transplant candidate with severe pulmonary hypertension and extremely high pulmonary vascular resistance., J Artif Organs, 10.1007/s10047-013-0695-3, 16, 2, 253-257, 2013.06.
41. Kongphanich A, Hieda M, Kurokawa K, Murata T, Kobayashi N, Overcoming the blockade at the upstream of caspase cascade in Fas-resistant HTLV-I-infected T cells by cycloheximide., Biochem Biophys Res Commun, 10.1016/S0006-291X(02)00531-4, 294, 3, 714-718, 2002.06.