Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Nobuyuki Ono Last modified date:2021.08.05

Assistant Professor / DEPARTMENT OF MEDICINE AND BIOSYSTEMIC SCIENCE / Department of Clinical Immunology and Rheumatology / Infectious Disease / Kyushu University Hospital

1. The impact on patient outcomes of the recent treatment strategy for ANCA associated vasculitis.
[Objective]Recently, the treatment strategy of ANCA associated vasculitis(AAV) has changed with the intensive corticosteroid(CS) tapering and RTX therapy. We studied the impact on patient outcomes of the recent treatment strategy for AAV.
[Methods]By using the database of our multi-center vasculitis cohort study, we recruited AAV patients except for EGPA, who were followed for more than two years. We compared two groups, which were divided based on dates of diagnosis.
[Results]The former group(2012/1~2015/5) had 57 patients, and the latter(2015/6~) had 59 patients. The median ages were 69 years old and 74 years old, respectively. There were no differences in sex, ANCA status and BVAS scores. The latter had less MPA(59.7% vs 35.6%) more unclassified AAV(8.8% vs 28.8%). For initial remission induction, the latter used less CY (40% vs 14%), but more RTX(2% vs 22%). The latter group tapered CS more intensively (median PSL dose(mg/day) : 10 vs 8 (0.5 y), 9 vs 4(1y), 6 vs 3(2y)). Remission, relapse and survival rates were comparable. VDI were decreased (averages :1.7 vs 1.1(0.5 y), 1.8 vs 1.2(1y), 2.2 vs 1.3(2y)).
[Conclusions]We found that the recent AAV treatment strategy with intensive CS tapering and RTX inhibited the progression of vasculitis organ damages..