九州大学 研究者情報
論文一覧
朝川 美加李(あさかわ みかり) データ更新日:2022.06.20

助教 /  歯学研究院 歯学部門 口腔保健推進学講座


原著論文
1. Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Yoshihiro Shimazaki, Jun Hata, Toshiharu Ninomiya, Yoshihisa Yamashita., Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: Estimates of population attributable risk in a Japanese community, Journal of Periodontology, 10.1002/JPER.21-0191., 93(4):526-536., 2022.04.
2. Jiale Ma, Michiko Furuta, Kazuhiro Uchida, Toru Takeshita, Shinya Kageyama, Mikari Asakawa, Kenji Takeuchi, Shino Suma, Satoko Sakata, Jun Hata, Woosung Sohn, Toshiharu Ninomiya, Yoshihisa Yamashita., Yogurt product intake and reduction of tooth loss risk in a Japanese community, Journal of clinical periodontology, 10.1111/jcpe.13593., 49(4):345-352., 2022.04.
3. Shinya Kageyama, Michiko Furuta, Toru Takeshita, Jiale Ma, Mikari Asakawa, Yoshihisa Yamashita., High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota, mBio, 10.1128/mbio.03452-21., 13(1):e0345221., 2022.01.
4. Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Jun Hata, Daigo Yoshida, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yoshihisa Yamashita., 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study, BMJ Open, 10.1136/bmjopen-2020-048114., 11(8):e048114., 2021.08.
5. Jiale Ma, Shinya Kageyama, Toru Takeshita, Yukie Shibata, Michiko Furuta, Mikari Asakawa, Yoshihisa Yamashita., Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis, PLoS One, 10.1371/journal.pone.0253502., 25;16(6):e0253502., 2021.06.
6. Daixi Zhang, Toru Takeshita, Michiko Furuta, Shinya Kageyama, Mikari Asakawa, Koki Nambu, Yoshihisa Yamashita, Tongue Microbiota Composition and Dental Caries Experience in Primary School Children., mSphere, 10.1128/mSphere.01252-20, 6, 2, 2021.04, The tongue microbiota of elderly adults is composed of two cohabiting commensal groups and their ratios are related to the number of teeth with dental caries experience. In this study, the variation in the tongue microbiota of primary school children and its relationship with the dental caries experience were investigated. We examined the tongue microbiota of 138 children aged 6 to 7 years and 11 to 12 years (61 and 77 children, respectively) who underwent annual dental examinations. The bacterial composition was determined by sequencing the V1-V2 region of the 16S rRNA gene. Cooccurrence network analysis indicated two groups of cohabiting predominant commensals in the tongue microbiota of children. The microbiota in children without a history of dental caries showed significantly higher relative abundances of one of the cohabiting groups, primarily composed of Neisseria subflava, Porphyromonas pasteri, and Fusobacterium periodonticum, compared to that in children with a history of dental caries, which is consistent with that of elderly adults with fewer teeth with dental caries experience. Linear discriminant analysis effect size (LEfSe) further identified Streptococcus oralis subsp. dentisani, belonging to the aforementioned commensal group, as a discriminant species in children without dental caries experience aged 6 to 7 years and 11 to 12 years. Our results describe the tongue microbiota composition of primary school children without history of dental caries and support the possibility that dental caries experience is accompanied by a shift in the tongue microbiota.IMPORTANCE Dental caries is now considered to be caused by acids produced by the overall dental plaque microbiota rather than by specific pathogens. This study focused on the relationship between dental caries experience and the variations in tongue microbiota, which is adjacent but separate from the dental plaque microbiota. Our results demonstrated that the tongue microbiota of primary school children with no history of dental caries experience was composed of predominant commensals with different relative abundances compared to those present in children with dental caries experience, suggesting that dental caries experience is accompanied by a shift in the tongue microbiota. The maintenance of a healthy tongue microbiota may indirectly contribute to the prevention of dental caries..
7. Toru Takeshita, Koichiro Matsumoto, Michiko Furuta, Satoru Fukuyama, Kenji Takeuchi, Hiroaki Ogata, Mikari Asakawa, Shinya Kageyama, Jun Hata, Toshiharu Ninomiya, Hiromasa Inoue, Yoshihisa Yamashita, Airflow limitation and tongue microbiota in community-dwelling elderly individuals., ERJ open research, 10.1183/23120541.00616-2020, 7, 2, 2021.04, Numerous oral indigenous microorganisms are constantly introduced into the stomach via the laryngopharynx, and a portion of these microorganisms irregularly reaches the lower airways and lungs. This study investigated the association between airflow limitation and the status of tongue microbiota, which is a primary source of ingested oral bacterial populations. The study population consisted of 484 community-dwelling adults aged 70-80 years inhabiting Hisayama town, Japan, who underwent a regular health examination including dental examination and spirometry test in 2016. The bacterial density and composition of their tongue microbiota were determined using a previously used 16S rRNA gene to understand their relationship with oral health conditions. The present cross-sectional study compared the tongue microbiota status between elderly individuals with airflow limitation and those with normal airflow. The total bacterial density of the tongue microbiota of individuals with airflow limitation was significantly higher than that of individuals with normal airflow. Logistic regression analysis demonstrated that a high-biomass tongue microbiota was significantly associated with airflow limitation after adjustment for smoking intensity and other covariates (adjusted OR 1.61, 95% CI 1.01-2.60). Of the predominant commensals, higher amounts of Prevotella melaninogenica and Actinomyces odontolyticus were associated with a higher prevalence of airflow limitation. These results indicate that increased bacterial burden in the tongue microbiota is associated with a higher prevalence of airflow limitation..
8. Shinya Kageyama, Yuka Nagao, Jiale Ma, Mikari Asakawa, Ryoji Yoshida, Toru Takeshita, Akiyuki Hirosue, Yoshihisa Yamashita, Hideki Nakayama, Compositional Shift of Oral Microbiota Following Surgical Resection of Tongue Cancer, Frontiers in Cellular and Infection Microbiology, 10.3389/fcimb.2020.600884, 10, 2020.11, [URL].
9. Nao Suzuki, Richiko Beppu, Masahiro Yoned, Toru Takeshita, Mikari Asakawa, Yoshihisa Yamashita, Takashi Hanioka, Takao Hirofuji, Tetsuo Shinohara, Effects of eradication of Helicobacter pylori on oral malodor and the oral environment: a single-center observational study, BMC Research Notes, 10.1186/s13104-020-05253-5, 13(1):406., 2020.08, [URL].
10. Saori Oku, Toru Takeshita, Toshiko Futatsuki, Shinya Kageyama, Mikari Asakawa, Yasuo Mori, Toshihiro Miyamoto, Jun Hata, Toshiharu Ninomiya, Haruhiko Kashiwazaki, Yoshihisa Yamashita., Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation., PLoS pathogens, 10.1371/journal.ppat.1008348, 16, 3, 2020.01, [URL].
11. Ogata K, Takeshita T, Shibata Y, Matsumi R, Kageyama S, Asakawa M, Yamashita Y., Effect of coffee on the compositional shift of oral indigenous microbiota in in vitro cultivation., Journal of Oral Science, 10.2334/josnusd.18-0269, 61, 3, 418-424, 2019.09, [URL].
12. Shinya Kageyama, Toru Takeshita, Kenji Takeuchi, Mikari Asakawa, Rie Matsumi, Michiko Furuta, Yukie Shibata, Kiyoshi Nagai, Masahiko Ikebe, Masaru Morita, Muneyuki Masuda, Yasushi Toh, Yutaka Kiyohara, Toshiharu Ninomiya, Yoshihisa Yamashita., Characteristics of the salivary microbiota in patients with various digestive tract cancers., Frontiers in Microbiology, 10.3389/fmicb.2019.01780, 10, 2019.08, [URL].
13. Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y., Tongue microbiota and oral health status in community-dwelling elderly adults., mSphere, 10.1128/mSphere.00332-18, 3, 4, 2018.08, [URL].
14. Kageyama S, Asakawa M, Takeshita T, Ihara Y, Kanno S, Hara T, Takahashi I, Yamashita Y., Transition of bacteria diversity and composition in tongue microbiota during the first 2 years of life., mSphere, 10.1128/mSphere.00187-19, 4, 3, 2019.05, [URL].
15. Takeuchi K, Asakawa M, Hashiba T, Takeshita T, Saeki Y, Yamashita Y., Effects of xylitol-containing chewing gum on the oral microbiota., Journal of Oral Science, 10.2334/josnusd.17-0446, 60, 4, 588-594, 2018.12, [URL].
16. Kageyama S, Takeshita T, Asakawa M, Shibata Y, Takeuchi K, Yamanaka W, Yamashita Y., Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis., PLoS One, 10.1371/journal.pone.0174782, 12, 4, 2017.03.
17. Kageyama S, Takeshita T, Furuta M, Tomioka M, Asakawa M, Suma S, Takeuchi K, Shibata Y, Iwasa Y, Yamashita Y., Relationship of variations in the tongue microbiota and pneumonia mortality in nursing home residents., Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 10.1093/gerona/glx205, 73, 8, 1097-1102, 2018.07.
18. Yukari Ihara, Toru Takeshita, Shinya Kageyama, Rie Matsumi, Mikari Asakawa, Yukie Shibata, Yuki Sugiura, Kunio Ishikawa, Ichiro Takahashi, Yoshihisa Yamashita., Identification of initial colonizing bacteria in dental plaques from young adults using full-length 16S rRNA gene sequencing., mSystems, 10.1128/mSystems.00360-19, 4, 5, 2019.01, [URL].

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