| 今井 実喜生（いまい みきお） | データ更新日：2024.04.02 |
助教 ／
歯学研究院
歯学部門
| 1. | 大木 郷資, 荻野洋一郎, 今井実喜生, 上田 将之, 木下 康平, 松村 英尚, 古谷野 潔, マウスガードの咬合接触範囲が起立動作能力に与える影響についての検討., 2021.06. |
| 2. | Sanda K, Yasunami N, Matsushita Y, Furuhashi A, Matsuzaki T, Imai M,Cheng C, Koyano K. The International Journal of Prosthodontics , Trueness of the combined intra- and extraoral scanning technique for transferring subgingival contours from provisional restorations to definitive restorations., The International Journal of Prosthodontics, 2021.06. |
| 3. | Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano. , Therapeutic effect of fluvastatin on medication-related osteonecrosis of the jaw., Journal of Periodontology, 9:1-10. 2021, 2022.06. |
| 4. | Oki K, Ogino Y, Takamoto Y, Imai M, Takemura Y, Ayukawa Y, Koyano K., The Significance of Posterior Occlusal Support of Teeth and Removable Prostheses in Oral Functions and Standing Motion. , International Journal of Environmental Research and Public Health, 18: 6776(1-11). 2021, 2021.06. |
| 5. | 木下 康平,大木 郷資, 今井 実喜生, 上田 将之, 松村 英尚, 古谷野 潔, カスタムメイドマウスガードの装着が起立動作能力に与える影響, スポーツ歯学, 第23巻第2号 2019, 2019.12. |
| 6. | Mikio Imai, Yasunori Ayukawa, Noriyuki Yasunami, Akihiro Furuhashi, Yoko Takemura, Naomi Adachi, Jiangqi Hu, Xudiyang Zhou, Yasuko Moriyama, Ikiru Atsuta, Kosaku Kurata, Kiyoshi Koyano, Effect of a Single Injection of Benidipine-Impregnated Biodegradable Microcarriers on Bone and Gingival Healing at the Tooth Extraction Socket, Advances in Wound Care, 10.1089/wound.2018.0834, 8, 3, 108-117, 2019.03, [URL], Objective: A dihydropyridine-type calcium channel blocker, benidipine (BD), is extensively used in hypertension therapy. In vitro study reported BD promoting bone metabolism. We evaluated the effect of sustained release of BD-loaded poly(lactic-co-glycolic acid) (PLGA) microcarriers on the promotion of bone and gingival healing at an extraction socket in vivo. In addition, the effect of BD on osteoblasts, osteocytes, fibroblasts, and epithelial cells was evaluated in vitro. Approach: The maxillary first molar of rats was extracted. Next, PLGA microcarriers containing BD were directly injected into the gingivobuccal fold as a single dose. After injection, bone and soft-tissue healing was histologically evaluated. Effect of BD on proliferation, migration, and gene expression of gingival and bone cell was also examined in vitro. Results: After tooth extraction, BD significantly augmented bone volume and density, and also epithelial wound healing. During in vitro studies, BD promoted significant proliferation and migration of fibroblasts and epithelial cells. Real-time RT-PCR revealed that BD upregulated messenger RNA expression of Ahsg (alpha 2-HS glycoprotein) and Csf2 (colony-stimulating factor 2) in osteoblasts. Innovation: The prevention of bone and soft-tissue reduction associated with tooth extraction has been eagerly anticipated in the field of dentistry. This study first reported the effect of BD on extraction socket healing. Conclusion: A single dose of topically administered BD-loaded PLGA microcarriers promoted bone and soft-tissue healing at the extraction site of tooth..  |
| 7. | Naomi Adachi, Yasunori Ayukawa, Noriyuki Yasunami, Akihiro Furuhashi, Mikio Imai, Koma Sanda, Ikiru Atsuta, Kiyoshi Koyano, Preventive effect of fluvastatin on the development of medication-related osteonecrosis of the jaw, Scientific reports, 10.1038/s41598-020-61724-6, 10, 1, 2020.12, [URL], Medication-related osteonecrosis of the jaw (MRONJ) occurs in patients undergoing oral surgery while medicated with bisphosphonate, denosumab or anti-angiogenic agents. We employed a MRONJ-like rat model to investigate whether injecting fluvastatin at extraction sites prevents MRONJ-like lesion. A MRONJ-like model was created by treating rats with zoledronate and dexamethasone, extracting teeth, and immediately injecting fluvastatin at the extraction site. The experimental group comprised three subgroups treated with low (0.1 mg/kg; FS-L), medium (1.0 mg/kg; FS-M) and high concentrations (10 mg/kg; FS-H) of fluvastatin. Necrotic bone exposure was significantly lower in the FS-M (p = 0.028) and FS-H (p = 0.041) groups than in the MRONJ group. The distance between the edges of the epithelial surfaces was significantly shorter in the FS-M (p = 0.042) and FS-H (p = 0.041) groups. The area of necrotic bone and the necrotic bone ratio were significantly smaller in the FS-H group (p = 0.041 and p = 0.042 respectively). Bone volume fraction calculated on μ-CT images was significantly larger in the FS-H group than in the MRONJ group (p = 0.021). Our findings suggest that a single local injection of fluvastatin following tooth extraction can potentially reduce the chance of developing MRONJ-like lesion in rats.. |
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