Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Iwasaki Last modified date:2024.04.12

Associate Professor / Division of Diagnostic Pathology / Kyushu University Hospital


Papers
1. Kengo Kawaguchi, Kenichi Kohashi, Nokitaka Setsu, Koji Sagiyama, Makoto Endo, Takeshi Iwasaki, Yasuharu Nakashima, Yoshinao Oda, Rare presentation of a primary intraosseous glomus tumor in the humerus of a teenager., Skeletal radiology, 10.1007/s00256-024-04604-8, 2024.02, A glomus tumor is a benign mesenchymal tumor comprised of cells that resemble the perivascular modified smooth muscle cells of the glomus body. Glomus tumors typically appear in the superficial lesions of the soft tissue in the extremities, such as the subungual region. However, their occurrence in the bone is rare, with only about 30 cases reported to date. Half of these cases involved the distal phalanges of the fingers or toes, with only three reported cases involving the long bones. Here, we present the first case, a primary glomus tumor in the humerus of a 14-year-old female. An osteolytic and cystic lesion was detected after a pathological fracture occurred during exercise. Despite the tumor's large size, no pathological findings indicated malignancy. The fracture healed through conservative treatment, while the tumor was effectively managed with curettage. Appropriate medical care can be provided to patients by focusing on pathological findings..
2. Kengo Kawaguchi, Kenichi Kohashi, Takeshi Iwasaki, Taro Mori, Hiroshi Furukawa, Chiaki Sato, Hiroki Sonoda, Sakura Shiraishi, Makoto Endo, Yasuharu Nakashima, Yoshinao Oda, Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma., Virchows Archiv : an international journal of pathology, 10.1007/s00428-024-03796-7, 2024.03, Currently, it is difficult to predict the prognosis of myxoid liposarcoma (MLS) in biopsy specimens. In this study, we determined whether nuclear morphology may be used to predict the prognosis of MLS in primary biopsy specimens. Two pathologists evaluated nuclear morphology using the modified WHO/ISUP and Fuhrman grades. Survival analyses were performed by grouping nuclear high- and low-grades. We examined 53 MLS cases, which included 29 (54.7%) male and 24 (45.3%) female patients with a median age of 46 years (interquartile range, 37 - 60). In total, 7 (13.2%) and 16 (30.2%) cases were assigned to the high nuclear grade group based on the modified WHO/ISUP and Fuhrman gradings, respectively. Survival analyses revealed a significantly worse disease-free survival in the high-grade group (hazard ratio (HR), 7.51; 95% confidence interval (CI), 2.67-21.1, p 
3. Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takuma Izumi, Shohei Yoshiya, Takeo Toshima, Mizuki Ninomiya, Takeshi Iwasaki, Yoshinao Oda, Tomoharu Yoshizumi, Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma., Cancer science, 10.1111/cas.15981, 115, 1, 170-183, 2024.01, TP53-induced glycolysis and apoptosis regulator (TIGAR) is an important gene that encodes a regulatory enzyme of glycolysis and reactive oxygen species (ROS) detoxification and is associated with worse prognosis in various cancers. Ferroptosis is a recently identified type of programmed cell death that is triggered by iron-dependent lipid peroxidation. There are no reports on the prognostic impact of TIGAR on intrahepatic cholangiocarcinoma (ICC), and its role in ferroptosis is unclear. Ninety ICC patients who had undergone hepatic resection were enrolled. Immunohistochemical staining for TIGAR was performed. The regulation of malignant activity by TIGAR and the association between ferroptosis and TIGAR were investigated in vitro. Twenty-two (24.4%) patients were categorized into TIGAR-high and -low groups by immunohistochemical staining. There were no noticeable differences in background factors between the two groups, but TIGAR positivity was an independent prognostic factor in disease-free survival (hazard ratio [HR], 2.00; 95% confidence interval [CI], 1.04-3.85, p = 0.0378) and overall survival (HR, 2.10; 95% CI, 1.03-4.30, p = 0.00422) in a multivariate analysis. In vitro, TIGAR knockdown (KD) decreased cell motility (cell proliferation/migration/invasion/colony-forming capabilities) and elevated ROS and lipid peroxidation. This indicated that TIGAR KD induced ferroptosis. TIGAR KD-induced ferroptosis was suppressed using liproxstatin. TIGAR KD decreased the expression of glutathione peroxidase 4, known as factor-suppressing ferroptosis. The combination of TIGAR KD with cisplatin significantly induced more ferroptosis. In conclusion, TIGAR is associated with poor outcomes in ICC patients and resistance to ferroptosis..
4. Naomi Magarifuchi, Takeshi Iwasaki, Yoshihiro Katayama, Takumi Tomonaga, Miya Nakashima, Fumiya Narutomi, Kiyoko Kato, Yoshinao Oda, Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma., Oncology letters, 10.3892/ol.2024.14329, 27, 5, 196-196, 2024.05, Ovarian high-grade serous carcinoma (OHGSC) is the most common type of ovarian cancer worldwide. Genome sequencing has identified mutations in chromatin remodeling factors (CRFs) in gynecological cancer, such as clear cell carcinoma, endometrioid carcinoma and endometrial serous carcinoma. However, to the best of our knowledge, the association between CRFs and OHGSC remains unexplored. The present study aimed to investigate the clinicopathological and molecular characteristics of CRF dysfunction in OHGSC. CRF alterations were analyzed through numerous methods, including the analysis of public next-generation sequencing (NGS) data from 585 ovarian serous carcinoma cases from The Cancer Genome Atlas (TCGA), immunohistochemistry (IHC), and DNA copy number assays, which were performed on 203 surgically resected OHGSC samples. In the public NGS dataset, the most frequent genetic alteration was actin-like protein 6A (ACTL6A) amplification at 19.5%. Switch/sucrose non-fermentable related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 (SMARCC2) amplification (3.1%) was associated with significantly decreased overall survival (OS). In addition, chromodomain-helicase-DNA-binding protein 4 (CHD4) amplification (5.7%) exhibited unfavorable outcome trends, although not statistically significant. IHC revealed the protein expression loss of ARID1A (2.5%), SMARCA2 (2.5%) and SMARCA4 (3.9%). The protein expression levels of ACTL6A, SMARCC2 and CHD4 were evaluated using H-score. Patients with low protein expression levels of ACTL6A showed a significantly decreased OS. Copy number gain or gene amplification was demonstrated in ACTL6A (66.2%) and SMARCC2 (33.5%), while shallow deletion or deep deletion was demonstrated in CHD4 (70.7%). However, there was no statistically significant difference in protein levels of these CRFs, between the different copy number alterations (CNAs). Overall, OHGSC exhibited CNAs and protein loss, indicating possible gene alterations in CRFs. Moreover, there was a significant association between the protein expression levels of ACTL6A and poor prognosis. Based on these findings, it is suggested that CRFs could serve as prognostic markers for OHGSC..
5. Taro Mori, Takeshi Iwasaki, Hiroki Sonoda, Kengo Kawaguchi, Takumi Tomonaga, Hiroshi Furukawa, Chiaki Sato, Sakura Shiraishi, Kenichi Taguchi, Sadafumi Tamiya, Reiko Yoneda, Yumi Oshiro, Tomoya Matsunobu, Chie Abe, Yusuke Kuboyama, Nozomi Ueki, Kenichi Kohashi, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda, DDIT3-amplified or low-polysomic pleomorphic sarcomas without MDM2 amplification: Clinicopathological review and immunohistochemical profile of nine cases., Human pathology, 10.1016/j.humpath.2024.02.007, 145, 56-62, 2024.03, Several high-grade pleomorphic sarcoma cases that cannot be classified into any existing established categories have been reported. These cases were provisionally classified into undifferentiated pleomorphic sarcoma (UPS). Some dedifferentiated liposarcoma (DDLS) cases may also have been classified into the UPS category due to the absence of MDM2 amplification or an atypical lipomatous tumor/well-differentiated liposarcoma component. We retrieved and reviewed 77 high-grade pleomorphic sarcoma cases, initially diagnosed as UPS in 66 cases and DDLS in 11 cases. Fluorescence in situ hybridization (FISH) analyses of DDIT3 and MDM2 were performed for available cases. Of the cases successfully subjected to DDIT3 FISH (n = 56), nine (7 UPS and 2 DDLS) showed DDIT3 amplification but no MDM2 amplification. Two UPS cases showed both telomeric (5') and centromeric (3') amplification of DDIT3 or low polysomy of chromosome 12, whereas 5 UPS and 2 DDLS cases showed 5'-predominant DDIT3 amplification. Histopathologically, all cases showed UPS-like proliferation of atypical pleomorphic tumor cells. Immunohistochemically, only one case showed focal nuclear positivity for DDIT3, supporting the previous finding that DDIT3 expression was not correlated with DDIT3 amplification. All three cases with focal MDM2 expression involved 5'-predominant amplification, two of which showed DDLS-like histological features. The majority of cases (7/9) showed decreased expression in p53 staining, suggesting that DDIT3 amplification regulates the expression of TP53 like MDM2. From a clinicopathological perspective, we hypothesize that DDIT3-amplified sarcoma, especially with 5'-predominant amplification, can be reclassified out of the UPS category..
6. Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba, Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease, Frontiers in Immunology, 10.3389/fimmu.2023.1276014, 14, 2023.09.
7. Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Matsumoto T, Taniguchi M, Kuwamoto S, Umekita Y, Oda Y., Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma., Scientific Reports, 10.1038/s41598-023-40050-7., 13, 1, 2023.08.
8. Kengo Kawaguchi, Kenichi Kohashi, Taro Mori, Hidetaka Yamamoto, Takeshi Iwasaki, Izumi Kinoshita, Yosuke Susuki, Hiroshi Furukawa, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda, Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma., Journal of clinical pathology, 10.1136/jcp-2023-208814, 2023.05.
9. Takayuki Nakanishi, Yasuto Yoneshima, Koji Okamura, Toyoshi Yanagihara, Mikiko Hashisako, Takeshi Iwasaki, Naoki Haratake, Shun Mizusaki, Keiichi Ota, Eiji Iwama, Tomoyoshi Takenaka, Kentaro Tanaka, Tomoharu Yoshizumi, Yoshinao Oda, Isamu Okamoto, MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma., Cancer science, 10.1111/cas.15921, 2023.08.
10. Mikiko Hashisako*, Takeshi Iwasaki* (*Equally first), Takamasa Matsumoto, Yuichi Yamada, Takumi Miyamoto, Midori Taniguchi, Chiemi Oishi, Yoshinao Oda, Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma, Pathol Res Pract, 10.1016/j.prp.2023.154384., 244, 2023.04.
11. Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori, Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. , Cell Reports, doi: 10.1016/j.celrep.2022.111929., 42, 1, 111929, 2023.01.
12. Yu Toda, Hidetaka Yamamoto, Takeshi Iwasaki, Shin Ishihara, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Izumi Kinoshita, Daisuke Kiyozawa, Yuichi Yamada, Kenichi Kohashi, Atsushi Kimura, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda, Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma, PATHOLOGY RESEARCH AND PRACTICE, 10.1016/j.prp.2022.154239, 241, 2023.01.
13. Daisuke Kiyozawa, Kenichi Kohashi, Dai Takamatsu, Takeshi Iwasaki, Daiki Shibata, Takumi Tomonaga, Yuki Tateishi, Masatoshi Eto, Mitsuru Kinjo, Kenichi Nishiyama, Kenichi Taguchi, Yumi Oshiro, Yusuke Kuboyama, Mitsuko Furuya, Yoshinao Oda, Approach for reclassification of collecting duct carcinoma and comparative histopathological analysis with SMARCB1/INI1-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma., Human pathology, 10.1016/j.humpath.2022.03.002, 124, 36-44, 2022.06.
14. Shin Ishihara, Takeshi Iwasaki, Kenichi Kohashi, Kengo Kawaguchi, Yu Toda, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda, Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma., Journal of cancer research and clinical oncology, 10.1007/s00432-022-04078-y, 149, 6, 2425-2436, 2023.01.
15. Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda, Histological background of dedifferentiated solitary fibrous tumour., Journal of clinical pathology, 10.1136/jclinpath-2020-207311, 75, 6, 397-403, 2022.06.
16. Masahiko Tanigawa, Yutaka Koga, Yoshiki Naito, Hiroshi Yamaguchi, Takeshi Iwasaki, Kenichi Kohashi, Nobuyuki Ohike, Keiji Hanada, Michiyo Higashi, Masato Komatsu, Hiroshi Imai, Keisuke Yamakita, Tatsuya Nagakawa, Yoshinobu Okabe, Seiya Kato, Hirotsugu Noguchi, Toshiyuki Nakayama, Masanori Yasuda, Hironori Kusano, Jun Akiba, Yoshinao Oda, Hirohisa Yano, Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene., Histopathology, 10.1111/his.14703, 81, 3, 319-328, 2022.09.
17. Ishihara, Shin; Yamamoto, Hidetaka; Iwasaki, Takeshi; Toda, Yu; Yamamoto, Takeo; Yoshimoto, Masato; Ito, Yoshihiro; Susuki, Yousuke; Kawaguchi, Kengo; Kinoshita, Izumi; Yamada, Yuichi; Kohashi, Kenichi; Fujiwara, Toshifumi; Setsu, Nokitaka; Endo, Makoto; Matsumoto, Yoshihiro; Kakuda, Yuko; Nakashima, Yasuharu; Oda, Yoshinao, Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation, MODERN PATHOLOGY, 10.1038/s41379-021-00972-x, 2022.05.
18. Nobuko Yasutake, Takeshi Iwasaki, Hidetaka Yamamoto, Kenzo Sonoda, Keisuke Kodama, Kaoru Okugawa, Kazuo Asanoma, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda, Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma., Pathology, research and practice, 10.1016/j.prp.2022.153920, 235, 153920-153920, 2022.04.
19. Yuichi Yamada, Izumi Kinoshita, Yoshiko Miyazaki, Yuki Tateishi, Yusuke Kuboyama, Takeshi Iwasaki, Kenichi Kohashi, Hidetaka Yamamoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Mikiko Hashisako, Yui Yamada-Nozaki, Daisuke Kiyozawa, Taro Mori, Takeo Yamamoto, Kenji Tsuchihashi, Kazumi Kuriwaki, Munenori Mukai, Masataka Kawai, Keiko Suzuki, Hirotake Nishimura, Kenji Bando, Junya Masumoto, Mana Fukushima, Junichi Motoshita, Hiroki Mori, Akira Shiose, Yoshinao Oda, Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases., Virchows Archiv : an international journal of pathology, 10.1007/s00428-022-03293-9, 480, 4, 919-925, 2022.04.
20. Iwasaki, Takeshi; Hayashi, Kazuhiko; Matsushita, Michiko; Nonaka, Daisuke; Kohashi, Kenichi; Kuwamoto, Satoshi; Umekita, Yoshihisa; Oda, Yoshinao, Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma is Associated with JAK-STAT and MEK-ERK Pathway Activation, Cancer Science, https://doi.org/10.1111/cas.15187, 2022.01.
21. Takamichi Ito, Hiroki Hashimoto, Yuka Tanaka, Keiko Tanegashima, Maho Murata, Toshio Ichiki, Takeshi Iwasaki, Yoshinao Oda, Yumiko Kaku-Ito, TROP2 Expression in Sebaceous and Sweat Gland Carcinoma., Journal of clinical medicine, 10.3390/jcm11030607, 11, 3, 2022.01.
22. Momii K, Fujiwara T, Mae T, Tokunaga M, Iwasaki T, Shiomoto K, Kubota K, Onizuka T, Miura T, Hamada T, Nakamura T, Itokawa T, Iguchi T, Yamashita A, Kikuchi N, Nakaie K, Matsumoto Y, Nakashima Y, Risk factors for excessive postoperative sliding of femoral trochanteric fracture in elderly patients: A retrospective multicenter study, Injury, doi: 10.1016/j.injury.2021.07.039., 2021.08.
23. Shin Ishihara, Takeshi Iwasaki, Kenichi Kohashi, Yuichi Yamada, Yu Toda, Yoshihiro Ito, Yousuke Susuki, Kengo Kawaguchi, Dai Takamatsu, Shinichiro Kawatoko, Daisuke Kiyozawa, Taro Mori, Izumi Kinoshita, Hidetaka Yamamoto, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda, The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 10.1007/s00432-021-03616-4, 147, 7, 2003-2011, 2021.07.
24. Kiyozawa, Daisuke; Kohashi, Kenichi; Takamatsu, Dai; Yamamoto, Takeo; Eto, Masatoshi; Iwasaki, Takeshi; Motoshita, Junichi; Shimokama, Tatsuro; Kinjo, Mitsuru; Oshiro, Yumi; Yonemasu, Hirotoshi; Oda, Yoshinao, Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity, Human pathology, 10.1016/j.humpath.2021.03.009, 112, 48-58, 2021.06.
25. Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda, Histological background of dedifferentiated solitary fibrous tumour., Journal of clinical pathology, 10.1136/jclinpath-2020-207311, 2021.05.
26. Ishihara, Shin; Yamada, Yuichi; Iwasaki, Takeshi; Yoshimoto, Masato; Toda, Yu; Kohashi, Kenichi; Yamamoto, Hidetaka; Matsumoto, Yoshihiro; Nakashima, Yasuharu; Oda, Yoshinao, PD-L1 and IDO-1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I, ONCOLOGY REPORTS, 10.3892/or.2020.7837, 45, 1, 379-389, 2021.01.
27. Kinoshita I, Yamada Y, Kohashi K, Yamamoto H, Iwasaki T, Ishihara S, Toda YU, Ito Y, Susuki Y, Kawaguchi K, Ichiki T, Sato Y, Furue M, Nakashima Y, Oda Y., Frequent MN1 gene mutations in malignant peripheral nerve sheath tumor., Anticancer Res., doi: 10.21873/anticanres.14642., 40, 11, 6221-6228, 2020.11.
28. Iwasaki, Takeshi; Kohashi, Kenichi; Toda, Yu; Ishihara, Shin; Yamada, Yuichi; Oda, Yoshinao, Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 10.1007/s00432-020-03390-9, 2020.09.
29. Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y., Clinicopathological features and immunohistochemical utility of NTRK, ALK and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas. , Human pathology, doi: 10.1016/j.humpath.2020.09.004., 106, 82-92, 2020.09.
30. Yu Toda, Kenichi Kohashi, Yuichi Yamada, Masato Yoshimoto, Shin Ishihara, Yoshihiro Ito, Takeshi Iwasaki, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda, PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients
comparative study of primary and metastatic lesions, Journal of Cancer Research and Clinical Oncology, 10.1007/s00432-020-03242-6, 2020.05.
31. Iwasaki, Takeshi; Kohashi, Kenichi; Ohno, Masasuke; Taguchi, Tomoaki; Oda, Yoshinao, Establishment and Characterization of a Novel Primitive Yolk Sac Tumour Cell Line, TC587, ANTICANCER RESEARCH, 10.21873/anticanres.14007, 40, 2, 759-766, 2020.02.
32. Yamada, Yuichi; Kohashi, Kenichi; Kinoshita, Izumi; Yamamoto, Hidetaka; Iwasaki, Takeshi; Yoshimoto, Masato; Ishihara, Shin; Toda, Yu; Itou, Yoshihiro; Koga, Yutaka; Hashisako, Mikiko; Nozaki, Yui; Kiyozawa, Daisuke; Kitahara, Daichi; Inoue, Takeshi; Mukai, Munenori; Honda, Yumi; Toyokawa, Gouji; Tsuchihashi, Kenji; Matsushita, Yoshifumi; Fushimi, Fumiyoshi; Taguchi, Kenichi; Tamiya, Sadafumi; Oshiro, Yumi; Furue, Masutaka; Nakashima, Yasuharu; Suzuki, Satoshi; Iwaki, Toru; Oda, Yoshinao, Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death, VIRCHOWS ARCHIV, 10.1007/s00428-019-02622-9, 475, 4, 467-477, 2019.10.
33. Matsushita, Michiko; Iwasaki, Takeshi; Wardhani, Lusi Oka; Kuwamoto, Satoshi; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko, Decreased H3K27me3 Expression Is Associated With Merkel Cell Polyomavirus-negative Merkel Cell Carcinoma, Especially Combined With Cutaneous Squamous Cell Carcinoma, ANTICANCER RESEARCH, 10.21873/anticanres.13751, 39, 10, 5573-5579, 2019.10.
34. Wardhani, Lusi Oka; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko, Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma, Human pathology, 10.1016/j.humpath.2018.09.003, 84, 52-61, 2019.02.
35. Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration, Nature Communications, 10.1038/s41467-018-03845-1, 9, 1, 2018.05.
36. Yasutake N, Ohishi Y, Taguchi K, Hiraki Y, Oya M, Oshiro Y, Mine M, Iwasaki T, Yamamoto H, Kohashi K, Sonoda K, Kato K, Oda Y., Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma., Histopathology, 10.1111/his.13422, 2018.04.
37. Yamamoto, Hidetaka; Iwasaki, Takeshi; Yamada, Yuichi; Matsumoto, Yoshihiro; Otsuka, Hiroshi; Yoshimoto, Masato; Kohashi, Kenichi; Taguchi, Kenichi; Yokoyama, Ryohei; Nakashima, Yasuharu; Oda, Yoshinao, Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone, Human pathology, 10.1016/j.humpath.2017.11.020, 73, 41-50, 2018.03.
38. Yamada, Yuichi; Kinoshita, Izumi; Kenichi, Kohashi; Yamamoto, Hidetaka; Iwasaki, Takeshi; Otsuka, Hiroshi; Yoshimoto, Masato; Ishihara, Shin; Toda, Yu; Kuma, Yuki; Setsu, Nokitaka; Koga, Yuki; Honda, Yumi; Inoue, Takeshi; Yanai, Hiroyuki; Yamashita, Kyoko; Ito, Ichiro; Takahashi, Mitsuru; Ohga, Shouichi; Furue, Masutaka; Nakashima, Yasuharu; Oda, Yoshinao, Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant, HISTOPATHOLOGY, 10.1111/his.13377, 72, 3, 460-471, 2018.02.
39. Kondo, Yukari; Higa, Shinichiro; Iwasaki, Takeshi; Matsumoto, Tomoya; Maehara, Kazumitsu; Harada, Akihito; Baba, Yoshihiro; Fujita, Masatoshi; Ohkawa, Yasuyuki, Sensitive detection of fluorescence in western blotting by merging images, PLOS ONE, 10.1371/journal.pone.0191532, 13, 1, 2018.01.
40. Kuromi, Teruyuki; Matsushita, Michiko; Iwasaki, Takeshi; Nonaka, Daisuke; Kuwamoto, Satoshi; Nagata, Keiko; Kato, Masako; Akizuki, Gen; Kitamura, Yukisato; Hayashi, Kazuhiko, Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma, Human pathology, 10.1016/j.humpath.2017.05.011, 69, 8-14, 2017.11.
41. Matsushita, Michiko; Iwasaki, Takeshi; Nonaka, Daisuke; Kuwamoto, Satoshi; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko, Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas, YONAGO ACTA MEDICA, 60, 3, 145-153, 2017.09.
42. Wang H, Kohashi K, Yoshizumi T, Okumura Y, Tanaka Y, Shimokawa M, Iwasaki T, Aishima S, Maehara Y, Oda Y, Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma., Human Pathology, 10.1016/j.humpath.2017.03.007, 64, 69-75, 2017.06.
43. Taguchi, Hiroyuki; Xie, Yan; Horikoshi, Naoki; Maehara, Kazumitsu; Harada, Akihito; Nogami, Jumpei; Sato, Koichi; Arimura, Yasuhiro; Osakabe, Akihisa; Kujirai, Tomoya; Iwasaki, Takeshi; Semba, Yuichiro; Tachibana, Taro; Kimura, Hiroshi; Ohkawa, Yasuyuki; Kurumizaka, Hitoshi, Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8, BIOCHEMISTRY, 10.1021/acs.biochem.6b01098, 56, 16, 2184-2196, 2017.04.
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