Kyushu University Academic Staff Educational and Research Activities Database
List of Reports
Kuba Keiji Last modified date:2024.06.03

Professor / Science for Biological Information / Department of Basic Medicine / Faculty of Medical Sciences

1. Bernhard J. Haubner, Julia Schwighofer, Florian Huber, Greg Neely, Keiji Kuba, Elisabetta Conci, Markus C. Stuehlinger, Hannes Alber, Otmar Pachinger, Josef Penninger, Bernhard Metzler, The absence of PI3K gamma is beneficial in a mouse model of myocardial ischemia/reperfusion, CIRCULATION, Vol.116, No.16, p.306, 2007.10.
2. Y. Imai, K. Kuba, J. M. Penninger, Angiotensin-converting enzyme 2 in acute respiratory distress syndrome, CELLULAR AND MOLECULAR LIFE SCIENCES, 10.1007/s00018-007-6228-6, Vol.64, No.15, pp.2006-2012, 2007.08, Angiotensin-converting enzyme (ACE) and ACE2 are highly homologous metalloproteases that provide essential catalytic functions in the renin-angiotensin system ( RAS). Angiotensin II is one key effector peptide of the RAS, inducing vasoconstriction and exerting multiple biological functions. ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 reduces angiotensin II levels. Accumulating evidence has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. Intriguingly, the SARS coronavirus, the cause of severe acute respiratory syndrome ( SARS), utilizes ACE2 as an essential receptor for cell fusion and in vivo infections. Moreover, recent studies have demonstrated that ACE2 protects murine lungs from acute lung injury as well as SARS-Spike protein-mediated lung injury, suggesting a dual role of ACE2 in SARS infections and protection from ARDS..
3. Bernhard Unsoeld, Manfred Schuster, Hans Loibner, Alexander Becker, Tim Seidler, Claudius Jacobshagen, Keiji Kuba, Yumiko Imai, Josef Penninger, Gerd Hasenfuss, Angiotensin-Converting-Enzyme 2 (rhACE2) Potently Attenuates the Negative Hemodynamic Effects of Angiotensin II (ATII) and Improves Post-Myocardial Infarction (MI) Remodeling, CIRCULATION, Vol.118, No.18, p.S947, 2008.10.
4. 脂質シグナリングとその破綻がもたらす病態の理解 心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割.
5. Tomokazu Yamaguchi, Ayumi Kadowaki, Yukio Koizumi, Miyuki Natsui, Chitose Satou, Yumiko Imai, Keiji Kuba, Dissecting the role of CCR4-NOT-associated ubiquitin converting enzyme in controlling heart functions, JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol.128, No.3, p.S147, 2015.07.
6. Yukio Koizumi, Tomokazu Yamaguchi, Ayumi Kadowaki, Miyuki Natsui, Chitose Sato, Yumiko Imai, Keiji Kuba, A crucial role of CNOT3 in stem cell proliferation and early embryonic development, JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol.128, No.3, p.S250, 2015.07.
7. Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Miyuki Natsui, Ayumi Kadowaki, Chitose Sato, Yukio Koizumi, Akinori Takahashi, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba, Analysis for the role of CCR4-NOT complex in regulation of adenine nucleotide metabolism in the hearts, JOURNAL OF PHARMACOLOGICAL SCIENCES, Vol.130, No.3, p.S78, 2016.03.
8. 環状ペプチドマルホルミンが賦活化する細胞性血栓溶解にはRSK1の活性化が関与する.