Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Toshiyuki Sasaguri Last modified date:2019.06.26

Professor / Science for Biological Information / Department of Basic Medicine / Faculty of Medical Sciences

1. Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T., 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation., Biochem Pharmacol, in press, 2019.06.
2. Yoshihara T, Zaitsu M, Shiraishi F, Arima H, Takahashi-Yanaga F, Arioka M, Kajioka S, Sasaguri T., Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers., J Pharmacol Sci, 139, 3, 209-214, 2019.03.
3. Fujita A, Hayamizu K, Yoshihara T, Zaitsu M, Shiraishi F, Arima H, Matsuo K, Shiokawa K, Setoguchi H, Sasaguri T., Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration., JA Clinical Reports, 4, 59, 2018.01.
4. Hayamizu K, Morimoto S, Nonaka M, Hoka S, Sasaguri T., Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients., Arch Biochem Biophys, 637, 40-47, 2018.01.
5. Arioka M, Takahashi-Yanaga F, Tatsumoto N, Sasaguri T. , Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression., Biochem Biophys Res Commun, 493, 1, 9-13, 2017.11.
6. Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Tomooka K, Sasaguri T., Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion., Biochem Pharmacol, 138, 31-48, 2017.08.
7. Nagano A, Arioka M, Takahashi-Yanaga F, Matsuzaki E, Sasaguri T., Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes., J Pharmacol Sci, 133, 1, 18-24, 2017.01.
8. Fujita A, Takahashi-Yanaga F, Morimoto S, Yoshihara T, Arioka M, Igawa K, Tomooka K, Hoka S, Sasaguri T., 2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through activation of GSK-3., Hypertens Res, 40, 2, 130-139, 2017.02.
9. Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T., Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway., Cancer Sci, 108, 1, 108-115, 2017.01.
10. Tatsumoto N, Arioka M, Yamada S, Takahashi-Yanaga F, Tokumoto M, Tsuruya K, Kitazono T, Sasaguri T., Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism., Physiol Rep, 2016.11.
11. Noma T, Takahashi-Yanaga F, Arioka M , Mori Y, Sasaguri T., Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells., Biochem Pharmacol, 116, 120-129, 2016.09.
12. Mohamed R, Morimoto S, Ibrahim I, Zhan DY, Du CK, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T., GSK3β heterozygous knockout is cardioprotective in a knock-in mouse model of familial dilated cardiomyopathy., Am J Physiol Heart Circ Physiol, 310, 11, H1808-H1815, 2016.06.
13. Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T., Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo., J Pharmacol Sci, 127, 4, 446-455, 2015.04.
14. Nonaka M, Morimoto S, Murayama T, Kurebayashi N, Li L, Wang YY, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T., Stage-dependent benefits and risks of pimobendan in genetic dilated cardiomyopathy mice with progressive heart failure., Br J Pharmacol, 172, 9, 2369-2382, 2015.05.
15. Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Hirata M, Mori Y, Sasaguri T., Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis., Biochem Pharmacol, 90, 4, 397-405, 2014.08.
16. Takahashi-Yanaga F, Yoshihara T, Jingushi K, Igawa K, Tomooka K, Watanabe Y, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Sasaguri T., DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice., Biochem Pharmacol, 89, 3, 340-348, 2014.06.
17. Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y,Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y; GEANE study group; HOMED-BP study group, Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study., Pharmacogenomics, 14, 14, 1709-1721, 2013.11.
18. Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Takashima A, Mori Y, Sasaguri T., Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in GSK-3β+/- mice., Biochem Biophys Res Commun, 440, 4, 677-682, 2013.11.
19. Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T,; The Comfort Investigators., Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study., QJM, 106, 10, 909-914, 2013.10.
20. Jingushi K, Nakamura T, Takahashi-Yanaga F, Matsuzaki E, Watanabe Y, Yoshihara T, Morimoto S, Sasaguri T., Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines, J Pharmacol Sci, 121, 2, 103-109, 2013.02.
21. Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S., Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction, Sci Rep, 2, 979, 2012.02.
22. Li L, Morimoto S, Take S, Zhan D-Y, Du, C-K, Wang, Y-Y, Fan X-L, Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T., Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure, J Mol Cell Cardiol, 53, 6, 760-767, 2012.12.
23. Matsumura, K., Arima, H., Tominaga, M., Ohtsubo, T., Sasaguri, T., Fujii, K., Fukuhara, M., Uezono, K., Morinaga, Y., Ohta, Y., Otonari, T., Kawasaki, J., Kato, I., Tsuchihashi, T. for the COMFORT Investigators, Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?, Circ J, 76, 6, 1415-1422, 2012.06.
24. Jingushi, K., Takahashi-Yanaga, F., Yoshihara, T., Shiraishi, F., Watanabe, Y., Hirata, M., Morimoto, S., & Sasaguri, T., DIF-1 Inhibits the Wnt/β-catenin Signaling Pathway by Inhibiting TCF7L2 Expression in Colon Cancer Cell Lines., Biochem Pharmacol, 83, 1, 47-56, 2012.01.
25. Yao, H., Miwa, Y., Takashima, Y., Yahara, K., Hashimoto, M., Uchino, A., Yuzuriha, T., & Sasaguri, T., Chronic kidney disease and subclinical lacunar infarction are independently associated with frontal lobe dysfunction in community-dwelling elderly subjects: the Sefuri brain MRI study., Hypertens Res, 34, 9, 1023-1028, 2011.09.
26. Sakata, S., Yoshihara, T., Arima, H., Shiraishi, F., Oniki, H., Takahashi-Yanaga, F., Matsumura, K., & Sasaguri, T., Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial., BMJ Open, 2011.07.
27. Fan, X., Takahashi-Yanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T., Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model., J. Pharmacol. Exp. Ther., 2011.07.
28. Sasaguri, T., Shiraishi, F., Yoshihara, T., Takahashi-Yanaga, F., & Morimoto, S., β1-adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects., J. Pharmacol. Sci., 115, 4, 490-499, 2011.04.
29. Miwa, Y., Tsuchihashi, T., Ohta, Y., Tominaga, M., Kawano, Y., Sasaguri, T., Ueno, M., & Matsuoka, H., Antiproteinuric effect of cilnidipine in hypertensive japanese treated with renin-angiotensin-system inhibitors - A multicenter, open, randomized trial using 24-hour urine collection., Clin. Exp. Hypertens., 32, 6, 400-405, 2010.12.
30. Toko, H., Takahashi, H., Kayama, Y., Oka, T., Minamino, T., Okada, S., Morimoto, S., Zhan, D.-Y., Terasaki, F., Anderson, ME., Inoue, M., Yao, A., Nagai, R., Kitaura, Y., Sasaguri, T., Komuro, I., Ca2+/calmodulin-dependent Kinase IIδ causes heart failure by accumulation of p53 in dilated cardiomyopathy., Circulation, 122, 9, 891-899, 2010.09.
31. Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S., & Sasaguri, T., Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/beta-catenin signaling pathway., Mol. Cancer, 9, 1, 245, 2010.07.
32. Takashima, Y., Miwa, Y., Mori, T., Hashimoto, M., Uchino, A., Yuzuriha, T., Sasaguri, T., & Yao, H., Sex differences in the risk profile and male predominance in silent brain infarction in community-dwelling elderly subjects: the Sefuri brain MRI study., Hypertens Res., 33, 7, 748-752, 2010.07.
33. Tadano, N., Du C.-K., Yumoto, F., Morimoto, S., Ohta, M., Xie, M.-F., Nagata, K., Zhan, D.-Y., Lu, Q.-W., Miwa, Y., Takahashi-Yanaga, F., Tanokura, M., Ohtsuki, I., & Sasaguri, T., Biological actions of green tea catechins on cardiac troponin C., Br. J. Pharmacol., 161, 5, 1034-1043, 2010.05.
34. Wang, Y.-Y., Morimoto, S., Du, C.-K., Lu, Q.-W., Zhan, D.-Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. , Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy., Cardiovasc. Res., 2010.03.
35. Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., & Sasaguri, T., Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity., J. Pharmacol. Sci., 112, 3, 320-326, 2009.03.
36. Ohmine, T., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., & Sasaguri, T., The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells., Hypertens Res, 32, 8, 690-699, 2009.08.
37. Zhan, D.-Y., Morimoto, S., Du, C.-K., Wang, Y.-Y., Lu, Q.-W., Tanaka, A., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. , Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation., Cardiovasc Res, 84, 1, 67-71, 2009.01.
38. Yao, H., Takashima, Y., Mori, T., Uchino, A., Hashimoto, M., Yuzuriha, T., Miwa, Y., & Sasaguri, T., Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study., Hypertens Res, 32, 7, 586-590, 2009.07.
39. Tadano, N., Morimoto, S., Takahashi-Yanaga, F., Miwa, Y., Ohtsuki, I., & Sasaguri, T., Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament., J. Pharmacol. Sci., 109(3), 456-458, 2009.06.
40. Tanaka, R., Miwa, Y., Mou, K., Tomikawa, M., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., Wake, N., & Sasaguri, T., Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. , Biochem. Biophys. Res. Commun., 378(4), 851-856, 2009.01.
41. Miwa, Y., Oda, H., Shiina, Y., Shikata, K., Tsushima, M., Nakano, S., Maruyama, T., Kyotani, S., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T., Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects., Hypertens Res., 31(10), 1931-1939, 2008.10.
42. Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M., & Sasaguri, T., Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells., Biochem. Biophys. Res. Commun., 377(4), 1185-1190, 2008.04.
43. Ohmine, T., Miwa, Y., Yao, H., Yuzuriha, T., Takashima, Y., Uchino, A., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., Sasaguri, T., Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects, Hypertens. Res., 31(1), 75-81, 2008.01.
44. Ngan, C.Y., Yamamoto, H., Takagi, A., Fujie, Y., Takemasa, I., Ikeda, M., Takahashi-Yanaga, F., Sasaguri, T., Sekimoto, M., Matsuura, N., Monden, M., Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells, Cancer Sci., 99(1), 129-139, 2008.01.
45. Du, C.-K., Morimoto, S., Nishii, K., Minakami, R., Ohta, M., Tadano, N., Lu, Q.-W., Wang, Y.-Y., Zhan, D.-Y., Mochizuki, M., Kita, S., Miwa, Y., Takahashi-Yanaga, F., Iwamoto, T., Ohtsuki, I., Sasaguri, T., Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation, Circ. Res., 101(2), 185-194, 2007.07.
46. Tadano, N., Morimoto, S., Yoshimura, A., Miura, M., Yoshioka, K., Sakato,M., Ohtsuki, I., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T., SCH00013, a novel Ca2+ sensitizer with positive inotropic and no chronotropic action in heart failure., J. Pharmacol. Sci., 10.1254/jphs.FP0040654, 97, 1, 53-60, 97(1), 53-60, 2005.01.
47. Miyagi, M., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T., Activator Protein-1 Mediates Shear Stress-Induced Prostaglandin D Synthase Gene Expression in Vascular Endothelial Cells., Arterioscler. Thromb. Vasc. Biol., 10.1161/01.ATV.0000159702.68591.0d, 25, 5, 970-975, 25(5), 970-975, 2005.01.
48. Miwa, Y., Takiuchi, S., Kamide, K., Yoshii, M., Horio, T., Tanaka, C., Banno, M., Miyata, T., Sasaguri, T., & Kawano, Y., Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females., Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.04.069, 331, 4, 1587-1593, 331(4), 1587-1593, 2005.01.
49. Mori, J., Takahashi-Yanaga, F., Miwa, Y., Watanabe, Y., Hirata, M., Morimoto, S., Shirasuna, K., & Sasaguri, T., Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma., Exp. Cell. Res., 10.1016/j.yexcr.2005.07.024, 310, 2, 426-433, 310(2), 426-433, 2005.01.
50. Yasmin, T., Takahashi-Yanaga, F., Mori, J., Miwa, Y., Hirata, M., Watanabe, Y., Morimoto, S., Sasaguri, T., Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells., Biochem. Biophys. Res. Commum., 10.1016/j.bbrc.2005.10.018, 338, 2, 903-909, 338(2), 903-909, 2005.01.
51. Yumoto, F., Lu, Q.-W., Morimoto, S., Tanaka, H., Kono, N., Nagata, K., Ojima, T., Takahashi-Yanaga, F., Miwa, Y., Sasaguri, T., Nishita, K., Tanokura, M. & Ohtsuki, I., Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy., Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.10.116, 338, 3, 1519-1526, 338(3), 1519-1526, 2005.01.
52. Miwa, Y., Tsushima, M., Arima, H., Kawano, Y., & Sasaguri, T., Pulse pressure is an independent predictor for the progression of aortic wall calcification in patients with controlled hyperlipidemia, Hypertension, 10.1161/01.HYP.0000117153.48029.d1, 43, 3, 536-540, 43(3),536-540, 2004.01.
53. Akaishi, E., Kobayashi, H., Narita, T., Kawai, S., Miwa, Y., Sasaguri, T., Hosaka, K. & Kubohara, Y., Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity, Eur. J. Pharmacol., 10.1016/j.ejphar.2003.11.041, 485, 1-3, 21-29, 485(1-3), 21-29, 2004.01.
54. Takahashi-Yanaga, F., Shiraishi, F., Hirata, M., Miwa, Y., Morimoto, S., & Sasaguri, T., Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK 1 in human skin fibroblasts., Biochem. Biophys. Res. Commum., 10.1016/j.bbrc.2004.02.061, 316, 2, 411-415, 316(2), 411-415, 2004.01.
55. Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T., Involvement of clusterin in 15-deoxy-Δ12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation., Biochem. Biophys. Res. Commum., 10.1016/j.bbrc.2004.04.163, 319, 1, 163-168, 319(1), 163-168, 2004.01.
56. Nakazono-Kusaba, A., Takahashi-Yanaga, F., Miwa, Y., Morimoto, S., Furue, M., & Sasaguri, T., PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts., Eur. J. Pharmacol., 10.1016/j.ejphar.2004.06.050, 497, 2, 155-160, 497(2), 155-160, 2004.01.
57. Takahashi-Yanaga, F., Taba, Y., Miwa, Y., Kubohara, Y., Watanabe, Y., Hirata, M., Morimoto, S., & Sasaguri, T., Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells, J. Biol. Chem., 10.1074/jbc.M205768200, 278, 11, 9663-9670, 278(11), 9663-9670, 2003.01.
58. Maiguma, T., Fujisaki, K., Itoh, Y., Makino, K., Teshima, D., Takahashi-Yanaga, F., Sasaguri, T., & Oishi, R., Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells, Naunyn Schmiedebergs Arch. Pharmacol., 10.1007/s00210-002-0660-9, 367, 3, 289-296, 367(3), 289-296, 2003.01.
59. Taba, Y., Miyagi, M., Miwa, Y., Inoue, H., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T., 15-Deoxy-Δ12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells, Am. J. Physiol. Heart Circ. Physiol., 10.1152/ajpheart.01037.2002, 285, 1, H38-H46, 285(1), H38-46, 2003.01.
60. Inoue, H., Taba, Y., Miwa, Y., Yokota, C., Miyagi, M., and Sasaguri, T., Induction of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells, Adv. Exp. Med. Biol., 525: 141-144, 2003.01.
61. Lu, Q-W. Morimoto, S. Harada, K., Du, C-K., Takahashi-Yanaga, F., Miwa, Y., Sasaguri, T. & Ohtsuki, I., Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T - tropomyosin interaction and causes a Ca2+-desensitization, J. Mol. Cell. Cardiol., 10.1016/j.yjmcc.2003.09.003, 35, 12, 1421-1427, 35(12), 1421-1427, 2003.01.
62. Yoshisue, H., Suzuki, K., Kawabata, A., Ohya, T., Zhao, H., Sakurada, K., Taba, Y., Sasaguri, T., Sakai, N., Yamashita, S., Matsuzawa, Y., & Nojima, H., Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library, Atherosclerosis, 162(2), 323-334, 2002.01.
63. Abumiya, T., Sasaguri, T., Taba, Y., Miwa, Y., & Miyagi, M., Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding site, Arterioscler. Thromb. Vasc. Biol., 22(6), 907-913, 2002.01.
64. Inoue, H., Taba, Y., Miwa, Y., Yokota, C., Miyagi, M., & Sasaguri, T., Transcriptional and post-transcriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells, Arterioscler. Thromb. Vasc. Biol., 10.1161/01.ATV.0000028816.13582.13, 22, 9, 1415-1420, 22(9), 1415-1420, 2002.01.
65. Nakazono-Kusaba, A., Takahashi-Yanaga, F., Morimoto, S., Furue, M., & Sasaguri, T., Staurosporine-induced cleavage of α-smooth muscle actin during myofibroblast apoptosis, J. Invest. Dermatol., 10.1046/j.1523-1747.2002.19525.x, 119, 5, 1008-1013, 119(5), 1008-1013, 2002.01.
66. Kosaka, C., Sasaguri, T., Komiyama, Y., & Takahashi, H, All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases, Hypertens. Res., 10.1291/hypres.24.579, 24, 5, 579-588, 24(5), 579-588, 2001.01.
67. Miwa, Y., Sasaguri, T., Kosaka, C., Taba, Y., Ishida, A., Abumiya, T., and Kubohara, Y, Differentiation-inducing factor-1, a morphogen of Dictyostelium, induces G1 arrest and differentiation of vascular smooth muscle cells, Circ. Res., 86, 1, 68-75, 86 (1): 68-75, 2000.01.
68. Sasaguri, T., Teruya, H., Ishida, A., Abumiya, T., and Ogata, J, Linkage between α1 adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells, Biochem. Biophys. Res. Commun., 268 (1): 25-30, 2000.01.
69. Akimoto, S., Mitsumata, M., Sasaguri, T., and Yoshida, Y, Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21Sdi1/Cip1/Waf1, Circ. Res., 86 (2): 185-190, 2000.01.
70. Taba, Y., Sasaguri, T., Miyagi, M., Abumiya, T., Miwa, Y., Ikeda, T., and Mitsumata, M, Fluid shear stress induces lipocalin-type prostaglandin D2 synthase expression in vascular endothelial cells, Circ. Res., 86 (9): 967-973, 2000.01.
71. Abumiya, T., Sakata, T., Enjoji, K., Kato, H., Kawai, J., Suzuki, T., Masuda, J., Sasaguri, T., and Ogata, J, Does hypertension confer a hypercoagulable state in stroke-prone spontaneously hypertensive rats?, J. Hypertens., 18 (7): 901-909, 2000.01.
72. Miwa, Y., Sasaguri, T., Inoue, H., Taba, Y., Ishida, A., and Abumiya, T, 15-Deoxy-D12,14-prostaglandin J2 induces G1 arrest and differentiation marker expression in vascular smooth muscle cells, Mol. Pharmacol., 58, 4, 837-844, 58 (4): 837-844, 2000.01.
73. Bhuiyan, Z. A., Yatsuki, H., Sasaguri, T., Joh, K., Soejima, H., Zhu, X., Hatada, I., Morisaki, H., Morisaki, T., and Mukai, T, Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome, Hum. Genet., 104 (3): 205-210, 1999.01.
74. Ishida, A., Sasaguri, T., Miwa, Y., Kosaka, C., Taba, Y., and Abumiya, T., Tumor suppressor p53 but not cGMP mediates NO-induced expression of p21Sdi1/Cip1/Waf1 in vascular smooth muscle cells, Mol. Pharmacol., 56, 5, 938-946, 56 (5): 938-946, 1999.01.
75. Ishida, A., Sasaguri, T., Kosaka, C., Nojima, H., and Ogata, J, Induction of the cyclin-dependent kinase inhibitor p21Sdi1/Cip1/Waf1 by nitric oxide-generating vasodilator in vascular smooth muscle cells, J. Biol. Chem., 272 (15): 10051-10057, 1997.01.
76. Kosaka, C., Sasaguri, T., Ishida, A., and Ogata, J, Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells, Am. J. Physiol., 270 (1 Pt 1): C170-C178, 1996.01.
77. Sasaguri, T., Ishida, A., Kosaka, C., Nojima, H., and Ogata, J, Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells, J. Biol. Chem., 271 (14): 8345-8351, 1996.01.
78. Shimokado, K., Yokota, T., Kosaka, C., Zen, K., Sasaguri, T., Masuda, J., and Ogata, J., Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells, Ann. NY. Acad. Sci., 748: 171-176, 1995.01.
79. Masuda, J., Ogata, J., Zen, K., Kosaka, C., Sasaguri, T., Shimokado, K., and Yutani, C., Artery-to-artery thromboembolism in cervicocephalic arteries and its potential roles in development of brain infarction, Ann. NY. Acad. Sci., 748: 491-493, 1995.01.
80. Zen, K., Masuda, J., Sasaguri, T., Kosaka, C., Shimokado, K., and Ogata, J., Protein tyrosine kinases and protein kinase C are required for gene expression of monocyte chemoattractant protein-1 in human monocytes, Ann. NY. Acad. Sci., 748: 508-509, 1995.01.
81. Kosaka, C., Sasaguri, T., Zen, K., Masuda, J., Shimokado, K., and Ogata, J., The protein kinase C pathway inhibits the proliferation of cultured vascular endothelial cells reducing cyclin A gene expression, Ann. NY. Acad. Sci., 748: 538-540, 1995.01.
82. Sasaguri, T., Kosaka, C., Zen, K., Masuda, J., Shimokado, K., and Ogata, J., Protein kinase C isoforms that may mediate G1/S inhibition in cultured vascular smooth muscle cells, Ann. NY. Acad. Sci., 748: 590-591, 1995.01.
83. Shimokado, K., Yokota, T., Umezawa, K., Sasaguri, T., and Ogata, J., Protein tyrosine kinase inhibitors inhibit chemotaxis of vascular smooth muscle cells, Arterioscler. Thromb., 14 (6): 973-981, 1994.01.
84. Zen, K., Masuda, J., Sasaguri, T., Kosaka, C., and Ogata, J., Gene expression of monocyte chemoattractant protein-1 in human monocytes is regulated by cell density through protein tyrosine kinase and protein kinase C, Exp. Cell Res., 215 (1): 172-179, 1994.01.
85. Shimokado, K., Yokota, T., Kato, N., Kosaka, C., Sasaguri, T., Masuda, J., Ogata, J., and Numano, F., Bidirectional regulation of smooth muscle cell proliferation by IFN-γ, J. Atheroscler. Thromb., 1 Suppl. 1: S29-S33, 1994.01.
86. Sasaguri, T., Kosaka, C., Hirata, M., Masuda, J., Shimokado, K., Fujishima, M., and Ogata, J., Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation: the isoforms that may mediate G1/S inhibition, Exp. Cell Res., 10.1006/excr.1993.1251, 208, 1, 311-320, 208 (1): 311-320, 1993.01.
87. Kosaka, C., Sasaguri, T., Masuda, J., Zen, K., Shimokado, K., Yokota, T., and Ogata, J., Prtein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells, Biochem. Biophys. Res. Commun., 193 (3): 991-998, 1993.01.
88. Sasaguri, T., Masuda, J., Shimokado, K., Yokota, T., Kosaka, C., Fujishima, M., and Ogata, J., Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression, Exp. Cell Res., 10.1016/0014-4827(92)90182-8, 200, 2, 351-357, 200 (2): 351-357, 1992.01.
89. Yokota, T., Shimokado, K., Kosaka, C., Sasaguri, T., Masuda, J., and Ogata, J., Mitogenic activity of interferon-γ on growth-arrested human vascular smooth muscle cells, Arterioscler. Thromb., 12 (12): 1393-1401, 1992.01.
90. Kosaka, C., Masuda, J., Shimokado, K., Zen, K., Yokota, T., Sasaguri, T., and Ogata, J., Interferon-γ suppresses PDGF production from THP-1 cells and blood monocyte-derived macrophages, Atherosclerosis, 97 (1): 75-87, 1992.01.
91. Sasaguri, T., Soejima, M., Hino, Y., Shiraishi, H., Date, H., Takasugi, M., Tanimoto, A., and Horie, A, Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis, Jpn. J. Med., 30 (5): 477-482, 1991.01.
92. Hirata, M., Kimura, Y., Ishimatsu, T., Yanaga, F., Shuto, T., Sasaguri, T., Koga, T., Watanabe, Y., and Ozaki, S., Synthetic inositol 1,3,4,5-tetrakisphosphate analogues, Biochem. J., 276, 333-336, 276 (2): 333-336, 1991.01.
93. Watson, S. P., Lai, J., and Sasaguri, T., K+-stimulation of the phosphoinositide pathway in guinea-pig ileum longitudinal smooth muscle is predominantly neuronal in origin and mediated by the entry of extracellular Ca2+, Br. J. Pharmacol., 99 (1): 212-216, 1990.01.
94. Sasaguri, T., and Watson, S. P., Phorbol esters inhibit smooth muscle contractions through activation of Na+, K+-ATPase, Br. J. Pharmacol., 99 (2): 237-242, 1990.01.
95. Sasaguri, T., and Watson, S. P., Protein kinase C regulates the tonic but not the phasic component of contraction in guinea-pig ileum, Br. J. Pharmacol., 98 (3): 791-798, 1989.01.
96. Sasaguri, T., and Watson, S. P., Lowering of the extracellular Na+ concentration enhances high K+-induced formation of inositol phosphates in the guinea-pig ileum, Biochem. J., 252 (3): 883-888, 1988.01.
97. Watson, S. P., Stanley, A. F., and Sasaguri, T., Does the hydrolysis of inositol phospholipids lead to the opening of voltage operated Ca2+ channels in guinea-pig ileum? Studies with fluoride ions and caffeine, Biochem. Biophys. Res. Commun., 153 (1): 14-20, 1988.01.
98. Sasaguri, T., Hirata, M., Itoh, T., Koga, T., and Kuriyama, H., Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein, Biochem. J., 239, 3, 567-574, 239 (3): 567-574, 1986.01.
99. Itoh, T., Kanmura, Y., Kuriyama, H., and Sasaguri, T., Nitroglycerine- and isoprenaline-induced vasodilatation: assessment from the actions of cyclic nucleotides, Br. J. Pharmacol., 84, 2, 393-406, 84 (2): 393-406, 1985.01.
100. Itoh, T., Sasaguri, T., Makita, Y., Kanmura, Y., and Kuriyama, H, Mechanisms of vasodilation induced by vasoactive intestinal polypeptide in rabbit mesenteric artery, Am. J. Physiol., 249, 2, H231-H240, 249 (2 Pt 2): H231-H240, 1985.01.
101. Hirata, M., Kukita, M., Sasaguri, T., Suematsu, E., Hashimoto, T., and Koga, T., Increase in Ca2+ permeability of intracellular Ca2+ store membrane of saponin-treated guinea pig peritoneal macrophages by inositol 1,4,5-trisphosphate, J. Biochem., 97, 6, 1575-1582, 97 (6): 1575-1582, 1985.01.
102. Suematsu, E., Hirata, M., Sasaguri, T., Hashimoto, T., and Kuriyama, H, Roles of Ca2+ on the inositol 1,4,5-trisphosphate-induced release of Ca2+ from saponin-permeabilized single cells of the porcine coronary artery, Comp. Biochem. Physiol., 82, 3, 645-649, 82A (3): 645-649, 1985.01.
103. Hirata, M., Sasaguri, T., Hamachi, T., Hashimoto, T., Kukita, M., and Koga, T., Irreversible inhibition of Ca2+ release in saponin-treated macrophages by the photoaffinity derivative of inositol 1,4,5-trisphosphate, Nature, 10.1038/317723a0, 317, 6039, 723-725, 317 (6039): 723-725, 1985.01.
104. Sasaguri, T., Hirata, M., and Kuriyama, H., Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery, Biochem. J., 231, 3, 497-503, 231 (3): 497-503, 1985.01.
105. Kuriyama, H., Itoh, T., Suematsu, E., Ueno, H., Kanmura, Y., and Sasaguri, T, Mechanisms of nitroglycerine-induced vasodilation: Assessment from actions of cyclin GMP, Jikeikai Med. J., 30 Suppl. 1: 105-116, 1984.01.