九州大学 研究者情報
論文一覧
王子田 彰夫(おうじだ あきお) データ更新日:2022.08.05

教授 /  薬学研究院 創薬科学部門


原著論文
1. Yoshihiro Egashira, Ayane Kumade, Akio Ojida, Fumihito Ono, Spontaneously Recycling Synaptic Vesicles Constitute Readily Releasable Vesicles in Intact Neuromuscular Synapses, J. Neurosci, 10.1523/JNEUROSCI.2005-21.2022 , 42, 17, 3523-3536, 2022.04.
2. Daiki Yamane, Satsuki Onitsuka, Suyong Re, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Eiji Kawanishi, Kenji Mizuguchi, Naoya Shindo, Akio Ojida, Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide,, Chemical Science, 10.1039/D1SC06596C, 13, 3027-3034, 2022.02.
3. Anna Kanegae, Yusuke Takata, Ippei Takashima, Shohei Uchinomiya, Ryosuke Kawagoe, Kazuteru Usui, Akira Yamashita, Jirarut Wongkongkatep, Manabu Sugimoto, Akio Ojida , A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene–metal-ion contact, Communications chemistry, 4, 104, 2021.07.
4. 王子田彰夫, 分子夾雑系で機能するコバレントドラッグの創薬化学, 月間 細胞, 53, 344-347, 2021.04.
5. Keisuke Tokunaga, Mami Sato, Keiko Kuwata, Chizuru Miura, Hirokazu Fuchida, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Naoya Shindo, Akio Ojida, Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins, J. Am. Chem. Soc., 10.1021/jacs.0c07490, 142, 43, 18522-18531, 2020.10.
6. Chizuru Miura, Naoya Shindo, Kei Okamoto, Tomoyo Osawa, Akio Ojida, Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoro acetamide Library, Chem. Pharm. Bull, 10.1248/cpb.c20-00547, 68, 11, 1074-1081, 2020.08.
7. Edurne Rujas, Sara Insausti, Daniel P. Leaman, Pablo Carravilla, Saul Gonza´ lez-Resines, Vale´ rie Monceaux, Rube´n Sa´ nchez-Eugenia, Miguel Garcı´a-Porras, Ibon Iloro, Lei Zhang, Fe´ lix Elortza, Jean-Philippe Julien, Asier Sae´ z-Cirio´ n, Michael B. Zwick, Christian Eggeling, Akio Ojida, Carmen Domene, Jose M.M. Caaveiro, Jose´ L. Nieva, Affinity for the Interface Underpins Potency of Antibodies Operating in Membrane Environments, Cell Reports, 10.1016/j.celrep.2020.108037, 32, 7, 108037, 2020.08.
8. Nattha Yongwattana, Nutsara Mekjinda, Wannee Thepsing, Supasara Ounsuk, Pravit Wongkongkatep, Tulyapruek Tawonsawatruk, Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep,, Fluorescence Determination of Soluble Pyrophosphate Levels in Synovial Fluid as a Marker of Pseudogout Using Middle Point of Quantification Concept and Molecular Sensor, ScienceAsia, 10.2306/scienceasia1513-1874.2020.S005, 46S, 1, 36-42, 2020.01.
9. Arinta Agnie Dewantari, Nattha Yongwattana, Panwajee Payongsri, Sawinee Seemakhan, Suparerk Borwornpinyo, Akio Ojida, Jirarut Wongkongkatep, Fluorescence Detection of Deoxyadenosine in Cordyceps spp. by Indicator Displacement Assay, Molecules, 10.3390/molecules25092045, 25, 9, 2045, 2020.03.
10. Noriaki Nakamura, Shohei Uchinomiya, Kazuya Inoue, Akio Ojida, Trimethyl-Substituted Carbamate as a Versatile Self-Immolative Linker for Fluorescence Detection of Enzyme Reactions, Molecules, 10.3390/molecules25092153, 25, 9, 2153, 2020.05.
11. Mami Sato, Hirokazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Hosokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, Akio Ojida, Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines, ACS Medicinal Chemistry Letters, 10.1021/acsmedchemlett.9b00574, 11, 6, 1137-1144, 2020.04.
12. Nattha Yongwattana , Nutsara Mekjinda, Tulyapruek Tawonsawatruk, Itaru Hamachi, Akio Ojida, JirarutWongkongkatep, Fluorescence Differentiation of ATP-Related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease Using Kyoto Green, Molecules, 10.3390/molecules25051116, 25, 1116, 2020.03.
13. Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo,Akio Ojida, Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells, Chem. Commun, 10.1039/C9CC09993J, 56, 3023-3026, 2020.02.
14. Nutsara Mekjinda, Supho Phunnarungsi, Vithaya Ruangpornvisuti, Raymond J. Ritchie, Itaru Hamachi,Akio Ojida, Masking Phosphate with Rare-Earth Elements Enables Selective Detection of Arsenate by Dipycolylamine-Zn(II) Chemosensor, Scientific Reports, 10, 2656, 2020.02.
15. Shigekazu Tabata, Marijo Jevtic, Nobutaka Kurashige, Hirokazu Fuchida, Munetsugu Kido, Kazushi Tani, Naoki Zenmyo, Shohei Uchinomiya, Harumi Harada, Makoto Itakura, Itaru Hamachi, Ryuichi Shigemoto, Akio Ojida, Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling, iScience, 10.1016/j.isci.2019.11.025, 22, 256-268, 2019.12.
16. 内之宮祥平, 王子田彰夫, 蛍光小分子プローブによる代謝経路活性の生細胞イメージング, 化学工業, 70, 5, 248-254, 2019.05.
17. 佐藤磨美, 王子田彰夫, タンパク質を標的とした創薬有機化学の新展開, 現代化学 = Chemistry today, 577, 32-36, 2019.04.
18. 王子田彰夫, 生体夾雑環境での創薬有機化学の新展開, 化学と工業 = Chemistry & chemical industry, 72, 5, 407-409, 2019.05.
19. 進藤直哉, 王子田彰夫, コバレントドラッグ創薬のための創薬有機化学, ファルマシア, 10.14894/faruawpsj.55.10_939, 55, 10, 939-943, 2019.10.
20. N. Zenmyo, H. Tokumaru, S. Uchinomiya, H. Fuchida, S. Tabata, I. Hamachi, R. Shigemoto, A. Ojida,, Optimized Reaction Pair of the CysHis Tag and Ni(II)-NTA Probe for Highly Selective Chemical Labeling of Membrane Proteins, Bull. Chem. Soc. Jpn, 10.1246/bcsj.20190034, 92, 5, 995-1000, 2019.03.
21. K. Usui, K. Yamamoto, Y. Ueno, K. Igawa, R. Hagihara, T. Masuda, A. Ojida, S. Karasawa, K. Tomooka, G. Hirai, H. Suemune, Internal‐Edge‐Substituted Coumarin‐Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self‐Assembly, Chem. Euro. J., 10.1002/chem.201803270, 24, 14617-14621, 2018.07.
22. A. Nishimura, T. Shimauchi, T. Tanaka, K. Shimoda, T. Toyama, N. Kitajima, T. Ishikawa, N. Shindo, T. Numaga-Tomita, S. Yasuda, Y. Sato, K. Kuwahara, Y. Kumagai, T. Akaike, T. Ide, A. Ojida, Y. Mori, M. Nishida, Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence, Science Signaling, 10.1126/scisignal.aat5185, 11, 556, eaat5185, 2018.11.
23. Naoya Shindo, Hirokazu Fuchida, Mami Sato, Kosuke Watari, Tomohiro Shibata, Keiko Kuwata, Chizuru Miura, Kei Okamoto, Yuji Hatsuyama, Keisuke Tokunaga, Seiichi Sakamoto, Satoshi Morimoto, Yoshito Abe, Mitsunori Shiroishi, Jose M. M. Caaveiro, Tadashi Ueda, Tomonori Tamura, Naoya Matsunaga, Takaharu Nakao, Satoru Koyanagi, Shigehiro Ohdo, Yasuchika Yamaguchi, Itaru Hamachi, Mayumi Ono ,Akio Ojida, Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Nature Chemical Biology
, 15, 250-258, 2019.01.
24. Nicolas Delsuc,Shohei Uchinomiya,Akio Ojida,Itaru Hamachi, A host–guest system based on collagen-like triple-helix hybridization, Chemical Communications, 10.1039/C7CC03055J, 53, 6856-6859, 2017.06.
25. Nobutaka Kurashige, Hirokazu Fuchida, Shigekazu Tabata, Shohei Uchinomiya,Akio Ojida, Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation, Bioorganic & Medicinal Chemistry Letters, 10.1016/j.bmcl.2017.05.069, 27, 3486-3489, 2017.03.
26. Jirarut Wongkongkatep, Akio Ojida, Itaru Hamachi, Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications, Topics in Current Chemistry, 10.1007/s41061-017-0120-0, 375, 2, 2017.04.
27. Ryosuke Kawagoe, Ippei Takashima, Shohei Uchinomiya, Akio Ojida, Reversible Ratiometric Detection of Highly Reactive Hydropersulfides Using a FRET-Based Dual Emission Fluorescent Probe, Chemical Science, 10.1039/C6SC03856E, 8, 1134-1140, 2016.09.
28. Eriko Aoyama, Hirokazu Fuchida, Yuji Oshikawa, Shohei Uchinomiya, Akio Ojida, Intracellular delivery of chemical probes using a glutathione-responsive traceless tag, Chemical Communications, 52, 7715-7718, 2016.06.
29. Naoya Matsunaga, Naoya Shindo, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo, Inhibition of G0/G1 switch 2 ameliorates renal inflammation in chronic kidney disease, EBioMedicin, 10.1016/j.ebiom.2016.10.008, 13, 262-273, 著者他21名, 2016.11.
30. Yuji Oshikawa, Kazuyuki Furuta, Satoshi Tanaka, Akio Ojida, Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement, Analytical Chemistry, 88, 1526-1529, 2016.01.
31. 王子田 彰夫, 高嶋 一平, 新しい蛍光センシング機構開発に基づいた細胞機能解析, 薬学雑誌, 136, 3-7, 2016.01.

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