九州大学 研究者情報
論文一覧
立花 宏文(たちばな ひろふみ) データ更新日:2024.02.02

教授 /  農学研究院 生命機能科学部門 食料化学工学


原著論文
1. Kwanwoo Lee,Motofumi Kumazoe,Yuki Marugame,Yoshinori Fujimura, andHirofumi Tachibana, Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by inhibition of neuronal maturation in adolescent mice, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2023.05.112, 669, 46-53, 2023.06.
2. Motofumi Kumazoe,Fumiyo Ogawa,Ai Hikida,Yu Shimada,Ren Yoshitomi,Ryoya Watanabe,Yoshinori Fujimura, andHirofumi Tachibana, Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1, Sci. Rep., Doi: 10.1038/s41598-023-29188-6, 13, 2128, 2023.02.
3. Motoki Murata,Yuki Marugame,Mai Morozumi,Kyosuke Murata,Motofumi Kumazoe,Yoshinori Fujimura, andHirofumi Tachibana, (-)-Epigallocatechin-3-O-gallate upregulated the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells, Biomedical Reports, doi: 10.3892/br.2023.1601, 18, 19, 2023.01.
4. Motoki Murata,Satomi Komatsu,Emi Miyamoto,Chihiro Oka,Ichian Lin,Motofumi Kumazoe,Shuya Yamashita,Yoshinori Fujimura, and Hirofumi Tachibana, Quercetin up-regulates the expression of tumor-suppressive miRNAs in human cervical cancer, Bioscience of Microbiota, Food and Health, 42, 87-93, 2023.01.
5. Yoshinori Fujimura,Takanori Yoshimoto,Konatsu Fujino,Ayaka Nezu,Yuki Marugame,Jaehoon Bae,Motofumi Kumazoe, andHirofumi Tachibana, Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin

, J. Nat. Med., doi: 10.1007/s11418-022-01668-5, 77, 363-369, 2022.12.
6. Jaehoon Bae,Kwanwoo Lee,Ji Sun Park,Jinseok Jung,Hirofumi Tachibana,Yoshinori Fujimura,Motofumi Kumazoe,Jae Sung Lim,Young-Chang Cho,Seung-Jae Lee and Su-Jin Park , Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells, Curr. Issues Mol. Biol.
, doi: 10.3390/cimb44120426, 44, 6247-6256, 2022.12.
7. @Tomomi Morikawa-Ichinose,@Yoshinori Fujimura,@Motofumi Kumazoe,@Hiroaki Onda,@Daisuke Miura,@Hirofumi Tachibana, Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment




, Food and Chemical Toxicology, doi: 10.1016/j.fct.2022.113421, 169, 113421, 2022.09.
8. @Motoki Murata,#Yuki Marugame,@Shuhei Yamada,@I-Chian Lin,@Shuya Yamashita,@Yoshinori Fujimura, and@Hirofumi Tachibana, Circulating miRNA profiles in mice plasma following flavonoid intake, Mol. Biol. Rep., doi: 10.1007/s11033-022-07918-9, 49, 10399-10407, 2022.09.
9. @Daiki Hayashi,@Varnavas D. Mouchlis,@Seika Okamoto,@Liuqing Wang,@Sheng Li,@Shuji Ueda,@Minoru Yamanoue,@Hirofumi Tachibana, @Hiroyuki Arai,@Hitoshi Ashida,@Edward A. Dennis, and@Yasuhito Shirai, Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase

, J. Nutr. Biochem, doi:10.1016/j.nutbio.2022.109129, 110, 109129, 2022.12.
10. Yu Shimada,Yuka Sato,Motofumi Kumazoe,Ryo Kitamura,Yoshinori Fujimura, andHirofumi Tachibana, Myricetin improve cognitive function in SAMP8 mice accompanied with upregulation of BDNF and NGF, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2022.05.039, 616, 33-40, 2022.05.
11. Yoshinori Fujimura,Mototsugu Watanabe,Tomomi Morikawa-Ichinose,Konatsu Fujino,Mao Yamamoto,Seita Nishioka,Chihiro Inoue, Fumiyo Ogawa,Madoka Yonekura,Akari Nakasone,Motofumi Kumazoe, andHirofumi Tachibana, Metabolic profiling for evaluating the dipeptidyl peptidase-IV inhibitory potency of diverse green tea cultivars and determining bioactivity-related ingredients and combinations, J. Agri. Food Chem, doi:10.1021/acs.jafc.2c01693, 70, 6455-6466, 2022.05.
12. Motofumi Kumazoe,Yoshinori Fujimura,Ren Yoshitomi,Yu Shimada,and Hirofumi Tachibana, Fustin, a flavanonol, synergically potentiates the anti-cancer effect of the green tea catechin EGCG with activation of the eNOS/cGMP axis, J. Agri. Food Chem, doi: 10.1021/acs.jafc.1c07567, 70, 3458-3466, 2022.02.
13. Motoki Murata,Kai Nakayama,Ryo Kitamura,Megumi Goto,Mai Morozumi,Takanori Yoshimoto,Yuki Marugame,Ren Yoshitomi,Shuya Yamashita,Yoshinori Fujimura, and Hirofumi Tachibana, Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice, Int. J.Gastronomy and Food Science, doi:10.1016/j.ijgfs.2022.100573, 29, 100573, 2022.09.
14. Yuki Marugame,Natsuko Takeshita,Shuhei Yamada,Ren Yoshitomi,Motofumi Kumazoe,Yoshinori Fujimura and Hirofumi Tachibana, Sesame Lignans Upregulate Glutathione S-transferase Expression and Downregulate microRNA-669c-3p, Bioscience of Microbiota, Food and Health, doi: 10.12938/bmfh. 2021-067, 41, 66-72, 2022.01.
15. Shuya Yamashita,Ichian Lin,Chihiro Oka,Motofumi Kumazoe,Satomi Komatsu,Motoki Murata,Shoko Kamachi,andHirofumi Tachibana, Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner, J. Nutr. Biochem., doi: 10.1016/j.jnutbio.2021.108910., 100, 108910, 2022.02.
16. Motofumi Kumazoe,Kanako Takamatsu,Fuyumi Horie,Ren Yoshitomi,Hiroki Hamagami,Hiroshi Tanaka,Yoshinori Fujimura,Hirofumi Tachibana, Methylated (−)-epigallocatechin 3-O-gallate potentiates split vaccine accompanied with upregulation of Toll-like receptor 5 , Sci. Rep., doi: 10.1038/s41598-021-02346-4., 11, 23101, 2021.11.
17. Ren Yoshitomi, Mao Yamamoto, Motofumi Kumazoe, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Akari Nakasone, Satoshi Kondo, Hiroki Hattori, Akane Haseda, Jun Nishihira, Hirofumi Tachibana, The combined effect of green tea and α-glucosyl hesperidin in preventing obesity:a randomized placebo-controlled clinical trial, Sci. Rep., doi: 10.1038/s41598-021-98612-6., 11, 19067, 2021.09.
18. Akira Iwamoto,Yuichi Inoue,Hirofumi Tachibana,Hiroharu Kawahara, Immunomodulatory effect of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in allergic conditions in vitro and in vivo, Cytotechnology, doi.org/10.1007/s10616-020-00438-z, 73, 333-342, 2021.06.
19. Motofumi Kumazoe, Yasutake Tanaka, Ren Yoshitomi, Yuki Marugame, Kwan-Woo Lee, Hiroaki Onda, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Hirofumi Tachibana, Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG, J. Natural Medicines, doi: 10.1007/s11418-021-01538-6, 75, 1037-1042, 2021.07.
20. Yoshinori Fujimura, Konatsu Fujino, Takanori Yoshimoto, Ayaka Nezu, Yuki Marugame, Jaehoon Bae, Motofumi Kumazoe, Hirofumi Tachibana, Eriodictyol-amplified 67-kDa laminin receptor signaling potentiates the anti-allergic effect of O-methylated catechin, J. Natural Products, doi: 10.1021/acs.jnatprod.1c00337, 84, 1823-1830, 2021.07.
21. Yasutake Tanaka,Motofumi Kumazoe,Hiroaki Onda,Yoshinori Fujimura, andHirofumi Tachibana, Oral EGCG administration time-dependently increases plasma cGMP concentration in mice, Food Bioscience, doi:10.1016/j.fbio.2021.101017, 41, 101017, 2021.06.
22. Ren Yoshitomi,Kai Nakayama,Shuya Yamashita,Motofumi Kumazoe,Ting-An Lin,Chen-Yi Mei,Yuki Marugame,Yoshinori Fujimura,Mari Maeda-Yamamoto,Shinichi Kuriyama, andHirofumi Tachibana, Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3, Sci. Rep., doi: 10.1038/s41598-020-67288-9, 10, 1, 10283, 2020.12, 葉酸のホモシステイン代謝促進活性にFolate Receptor 3が重要な役割を担っていることを発見した。.
23. Motoki Murata,Yuki Shimizu,Yuki Marugame,Ayaka Nezu,Konatsu Fujino,Syuhei Yamada,Motofumi Kumazoe,Yoshinori Fujimura, and Hirofumi Tachibana, EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol, J. Natural Medicines, doi:10.1007/s11418-020-01417-6, 74, 4, 637-679, 2020.05.
24. Motofumi Kumazoe,Mai Kadomatsu,Jaehoon Bae,Yushi Otsuka, Yoshinori Fujimura, and Hirofumi Tachibana, Src mediates epigallocatechin-3-O-gallate-elicited acid, Molecules, doi:10.3390/molecules25225481, 25, 22, 5481, 2020.11.
25. Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, and Hirofumi Tachibana, Cancer cell selective probe by mimicking EGCG, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2020.03.021, 525, 974-981, 2020.02.
26. Jaehoon Bae, Motofumi Kumazoe, Kyosuke Murata, Yoshinori Fujimura, and Hirofumi Tachibana, Procyanidin C1 inhibits melanoma cell growth by activating 67-kDa laminin receptor signaling, Molecular Nutrition & Food Research, doi: 10.1002/mnfr.201900986, 64, 1900986, 2020.04, 多彩な生体調節作用を示すプロシアニジンC1の受容体分子として67LRを同定するとともに受容体を介したプロシアニジンC1の生理活性発現メカニズムを明らかにした。.
27. Jaehoon Bae, Motofumi Kumazoe, Chieri Takeuchi, Shiori Hidaka, Yoshinori Fujimura, and Hirofumi Tachibana, Epigallocatechin-3-O-gallate induces acid sphingomyelinase activation through activation of phospholipase C, Biochem. Biophys. Res. Commun., doi: 10.1016/j.bbrc.2019.09.102., 520, 186-191, 2019.04.
28. Akira Iwamoto, Yuichi Inoue, Hirofumi Tachibana, Hiroharu Kawahara, Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro, Cytotechnology, 10.1007/s10616-019-00306-5, 71, 2, 573-581, 71(2), 573-58, 2019.04.
29. Jaehoon Bae, Motofumi Kumazoe, Yoshinori Fujimura, and Hirofumi Tachibana, Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity, J. Nutr. Biochem., 64, 152-161, 64, 152-161, 2019.02.
30. Masafumi Wasai, Haruna Nonaka, Motoki Murata, Ryo Kitamura, Yuka Sato, and Hirofumi Tachibana, Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8, Biosci. Biotechnol. Biochem., 10.1080/09168451.2018.1530093, 83, 339-347, 83, 339-347, 2018.10.
31. Masafumi Wasai, Yoshinori Fujimura, Haruna Nonaka, Ryo Kitamura, Motoki Murata, and Hirofumi Tachibana, Postprandial glycaemia-lowering effect of a green tea cultivar Sunrouge and cultivar-specific metabolic profiling for determining bioactivity-related ingredients, Sci. Rep., 10.1038/s41598-018-34316-8, 8, 16041, 8:16041, 2018.10.
32. Yoshito Abe, Naoki Odawara, Nantanat Aeimhirunkailas, Hinako Shibata, Naoki Fujisaki, Hirofumi Tachibana, Tadashi Ueda, Inhibition of amyloid fibril formation in the variable domain of 6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate, Biochim Biophys Acta Gen. Subj., 10.1016/j.bbagen.2018.08.006., 1862, 2570-2578, 1862, 2570-2578, 2018.08.
33. Masahiro Miyawaki, Hiroyuki Sano, Hisashi Imbe, Reiko Fujisawa, Keiji Tanimoto, Jungo Terasaki, Mari Maeda-Yamamoto, Hirofumi Tachibana, Akihisa Imagawa, Toshiaki Hanafusa, O-Methylated catechins from "Benifuuki" green tea reduce serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: a double-blind placebo-controlled randomized trial, Nutrients, 10.3390/nu10070924, 10, 924, 10, 924, 2018.07.
34. Shuya Yamashita, Asami Hirashima, I-Chian Lin, Jaehoon Bae, Kanami Nakahara, Motoki Murata, Shuhei Yamada, Motofumi Kumazoe, Ren Yoshitomi, Mai Kadomatsu, Yuka Sato, Ayaka Nezu, Ai Hikita, Konatsu Fujino, Kyosuke Murata, Mari Maeda-Yamamoto and Hirofumi Tachibana, Saturated fatty acid inhibits anti-obesity effect of green tea., Sci. Rep., 10.1038/s41598-018-28338-5, 8, 10023, 8:10023, 2018.07.
35. Mari Maeda-Yamamoto , Mie Nishimura, Nobuyoshi Kitaichi, Atsushi Nesumi, Manami Monobe, Sachiko Nomura, Yukihiko Horie, Hirofumi Tachibana, Jun Nishihira, A randomized, placebo-controlled study on the safety and efficacy of daily ingestion of green tea (Camellia sinensis L.) cv. “Yabukita” and “Sunrouge” on eyestrain and blood pressure in healthy adults, Nutrients, 2018, 10, 569; , 10.3390/nu10050569, 2018.02.
36. Hisashi Ohseto, Mami Ishikuro,Masahiro Kikuya,Taku Obara, Yuko Igarashi, Satomi Takahashi, Michiko Shigihara,Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, and Shinichi Kuriyama , Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: the Kakegawa cohort study., J. Psychosomatic Res., 107, 20-25 (2018), doi.org/10.1016/j.jpsychores.2018.01.013, 2018.02.
37. Masaomi Nimata, Hideki Okada, Kei Kurihara, Tsukasa Sugimoto, Tsutomu Honjoh, Kazuhiko Kuroda, Takeo Yano, Hirofumi Tachibana, and Masahiro Shoji , A harmonized immunoassay with liquid chromatograph-mass spectrometry analysis in egg allergen determination., Anal. Bioanal. Chem., 410, 325-335 (2018), 10.1007/s00216-017-0721-z., 2018.02.
38. Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa, and Hirofumi Tachibana, Green tea polyphenol EGCG upregulates Tollip expression by suppressing Elf-1 expression., J. Immunol., 199, 3261-3269 (2017), 10.4049/jimmunol.1601822., 2017.07.
39. Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana, Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells., Sci. Rep., 7, 6665 (2017), 10.1038/s41598-017-06879-5, 2017.07.
40. Masafumi Wasai, Nobuaki Urata, Yuji Fujii, Akiyoshi Kawaoka, Hirofumi Tachibana, Suguru Fujiwara, Katsuhisa Sakano, Mayumi Hayashi, Shukuko Ebihara, Effect of Sunrouge on the postprandial blood glucose level., Jpn. Pharmacol. Ther., 45, 105-111(2017), 2017.07.
41. Won, YS., Kumazoe, M., Takamatsu, K., Shinoda, Y., Sonoda, S., Okada, K., Okamoto, T., Tachibana, H., Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production, J. Nat. Med., 71, 68-75(2017), 10.1007/s11418-016-1028-7, 2017.07.
42. Yuko Igarashi, Taku Obara, Mami Ishikuro, Michiko Shigihara, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Youichi Samejima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama, Randomized controlled trial of the effects of consumption of "Yabukita" or "Benifuuki" encapsulated tea-powder on LDL cholesterol level and body weight., Food & Nutrition Research, 10.1080/16546628.2017.1334484., 10.1080/16546628.2017.1334484, 2017.06.
43. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Mai Kadomatsu, Takashi Nojiri, Hiroaki Onda, Jaehoon, B., Yuhui Huang, Takamatsu, K., Shuya Yamashita, Kenji Kangawa, Hirofumi Tachibana, The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma., J. Biol. Chem., doi:10.1074/jbc.M116.772111, 10.1074/jbc.M116.772111, 2017.05.
44. Yoshinori Fujimura, Chihiro Kawano, Ayaka Maeda-Murayama, Asako Nakamura, Kanako Takamatsu, Akiko Koike-Miki, Daichi Yukihira, Eisuke Hayakawa, Takanori Ishii, Hirofumi Tachibana, Hiroyuki Wariishi, Daisuke Miura, A Chemometrics-driven Strategy for the Bioactivity Evaluation of Complex Multicomponent Systems and the Effective Selection of Bioactivity-predictive Chemical Combinations., Sci. Rep., 7, 2257 (2017), 2017.04.
45. Motofumi Kumazoe, Takai, M., Jaehoon, B., Yuhui Huang, Takamatsu, K., Won, YS., Hiroi,S., Shuya Yamashita, Shuhei Yamada, Murata, M., Tsukamoto, S., Hirofumi Tachibana, FOXO3 is essential for CD44 expression in pancreatic cancer cells.
, Oncogene, doi:10.1038/onc.2016.426, 2017.03.
46. Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Takamatsu, K., Yuhui Huang, Jaehoon, B., Shuya Yamashita, Murata, M., Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana, Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Upregulation of E3 Ubiquitin-protein Ligase RNF216., J. Biol. Chem., 292, 4077-4088 (2017), 2017.03.
47. Masafumi Wasai, Nobuaki Urata, Yuji Fujii, Akiyoshi Kawaoka, Hirofumi Tachibana, Suguru Fujiwara, Katsuhisa Sakano, Mayumi Hayashi, Shukuko Ebihara, Effect of Sunrouge on the postprandial blood glucose level, Jpn. Pharmacol. Ther., 45, 105-111 (2017), 2017.03.
48. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Kanako Takamatsu, Yuhui Huang, Jaehoon, B., Shuya Yamashita, Shuhei Yamada, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana, PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma., Sci. Rep., 7, 1917 (2017), 2017.03.
49. Yuhui Huang, Mami Sumida,, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Fujimura Y, Hirofumi Tachibana, Oligomer formation of a tea polyphenol, EGCG on its sensing molecule the 67-kDa laminin receptor., Chemical Communication, 53, 1941-1944 (2017)
.
, 34, 2017.02.
50. Tsukamoto, S., Kumazoe, M., Huang, Y., Yamada, S., Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana, SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells
, Br. J. Haematol., in press, 2016.08.
51. Yamashita, M., Kumazoe, K., Nakamura, N., Won, YS., Bae, J., Yamashita, S., Hirofumi Tachibana, The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Accompanied by Suppression of Cholester, J.Nutr.Sci.Vit., 62, 249-256 (2016), 2016.08.
52. Hamagami, H., Kumazoe, K., Yamaguchi,Y., Fuse,S., Hirofumi Tachibana, Tanaka, H., 6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of zido-containing chemical probes.
, Chemistry - Eur. J., 22, 12884-12890 (2016)., 2016.08.
53. Shiraishi, N., Kumazoe, K., Fuse,S., Hirofumi Tachibana, Tanaka, H., The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR., Chemistry - Eur. J.,22, 13050-13053 (2016).
, 2016.08.
54. Kim, YH., Won, Y., Xue, Y., Kumazoe, K., Yamashita, S., Hara, A., Takagaki, A., Goto,K., Nanjo,F., Hirofumi Tachibana, Green Tea Catechin Metabolites Derived from Intestinal Bacteria Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activity, J. Agri. Food Chem., 64, 3591-3597 (2016), 34, 1162-1168, 2016.07.
55. Imbe, H., Sano, H., Miyawaki, M., Fujisawa, R., Miyasato, M., Nakatsuji, M., Haseda, F., Tanimoto, K., Hanafusa, T., Terasaki, J., Hirofumi Tachibana, Maeda-Yamamoto, M., "Benifuuki" Green Tea, Containing O-methylated EGCG, Reduces Serum Low-Density Lipoprotein Cholesterol and Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind, Placebo-Controlled Randomized Trial, J. Fuct. Foods 25, 25-37 (2016), 2016.07.
56. Motoki Murata, Haruna Nonaka, Satomi Komatsu, Kumazoe, K., Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Yamashita, S., Hirofumi Tachibana, Delphinidin prevents muscle atrophy and upregulates miR-23a expression., J. Agri. Food Chem., 65, 45-50 (2017)., 34, 1162-1168, 2016.07.
57. Lin, IC., Yamashita, S., Murata, M., Kumazoe, M., Hirofumi Tachibana, Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice.

, J. Nutr. Biochem., 32, 101-106 (2016), 6, 19225, 2016.05.
58. Hatasa, Y, Chikazawa, M., Furuhashi, M., Nakashima, F., Shibata, T., Kondo, T., Akagawa, M., Tanaka, H., Hirofumi Tachibana, Uchida, K., Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-gallate: Potential Mechanism for the Formation of Innate Antigens by Antioxidants, PLoS ONE, 11(4), e0153002 (2016), 2016.05.
59. Murata, M., Kosaka, R., Kurihara, K., Yamashita, S., Hirofumi Tachibana, Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression, Biosci. Biotechnol. Biochem., 80 (8), 1636-1640 (2016), 2016.05.
60. 宮崎義之, 倉田有希江, 古賀裕章, 山口智, 山田耕路, Hirofumi Tachibana, ザクロ酢のヒスタミン放出抑制活性におけるポリフェノール化合物の寄与, 日本食品科学工学会誌,63(2), 63-69 (2016)., ザクロ酢のヒスタミン放出抑制活性におけるポリフェノール化合物の寄与, 2016.02.
61. Yamada, S., Tsukamoto1, S., Huang, Y., Makio, A, Kumazoe, K., Yamashita, S., Hirofumi Tachibana, Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells
, Scientific Reports, 6, 19225 , 2016.01.
62. Yamada, S., Baba, K, Makio, A, Kumazoe, K., Huang, Y., Yamashita, S., Lin, IC., Bae, J., Murata, M., Yamada, S., Hirofumi Tachibana, γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein., Biochem. Biophys. Res. Commun., 473, 801-807(2016)., 6, 19225, 2016.01.
63. Tsukamoto, S., Huang, Y., Kumazoe, M., Kim, YH., Yamashita, S., Murata, M., Suzuki, T., Ueda, N., Yoshinori Fujimura, Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana, Sphingosine kinase-1 protects B-cell neoplasm and myeloid leukemia from apoptosis driven by cancer specific inhibition of RTKs., Mol. Cancer Theraputic., doi:10.1158/1535-7163.MCT-15-0185, 2015.08.
64. Huang, Y., Kumazoe, K., Bae, J., Yamada, S., Takai, M., Hidaka, S., Yamashita, S., Kim, YH., Won, Y., Murata, M., Tsukamoto1, S., Hirofumi Tachibana, Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells., Oncology Rep., 34, 1162-1168, 2015.07.
65. 上田京子, 塚谷忠之, 村山加奈子, 倉田有希江, 竹田絵理, 大塚崇文, 高井美佳, 宮崎義之, Hirofumi Tachibana, 山田耕路, ブロッコリーのビタミンC、S−メチルメチオニン、ポリフェノール含有量の部位別解析と細胞機能への影響, 日本食品科学工学会誌, 62, 5, 242-249, 2015.05.
66. Kumazoe, M., Yoshinori Fujimura, Shiori HIdaka, Kim, YH., Tsukamoto, S., Kanako Murayama, Mika Takai, Huang, Y., Yamashita, S., Daisuke Miura, Mari Maeda-Yamamoto, Hirofumi Tachibana, Metabolic profiling-based data-mining for an effective chemical combination to induce apoptosis of cancer cells., Sci. Rep., 5, 9474, 2015.03.
67. Kim, YH., Yamashita, S., Kumazoe, M., Huang, Y., Shiori HIdaka, Nakahara, K., Won, YS., Murata, M., Lin, I., Koji Yamada, Hirofumi Tachibana, Pentagalloylglucose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mouse, Int. Immunopharmacol., 26, 30-36, 2015.03.
68. Tsukamoto, S., Huang, Y., Umeda , D., Yamashita, S., Kumazoe, M., Murata, M., Kim, YH., Koji Yamada, Hirofumi Tachibana, 67kDa-laminin receptor-dependent PP2A activation elicits melanoma-specific antitumor activity overcoming drug resistance., J. Biol. Chem., 10.1074/jbc.M114.604983, 2014.12.
69. Takai, M, Miyazaki, Y., Koji Yamada, Hirofumi Tachibana, The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes., Biosci. Biotechnol. Biochem., 78, 1743-1747, 2014.09.
70. Kim, Y.H., Shuya Yamashita, Kumazoe, M., Yuhui Huang, Motoki Murata, Won, YS., Yamada, K., Ninomiya,Y., Tachibana H., IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation, Biochem. Biophys. Res. Commun., 450, 824-830, 2014.09.
71. Kumazoe, M., Tsukamoto, S., Lesnick, C, Kay, N. E., Koji Yamada, Shanafelt T. D., Hirofumi Tachibana, Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells., Br. J. Haematol. , 10.1111/bjh.13135, 2014.09.
72. Kim, YH., Yoshinori Fujimura, Masako Sasaki, Yang, X., Daichi Yukihira, Daisuke Miura, Unno, Y., Ogata, K., Hiroyuki Wariishi, Nakajima, H., Yamashita, S., Koji Yamada, Hirofumi Tachibana, Kanami Nakahara, Murata, M., Lin,I., In situ label-free visualization of orally dosed strictinin within mouse kidney by MALDI-MS imaging., J. Agri. Food Chem., 62, 9279-9285, 2014.09.
73. Takashi Suzuki, Shuya Yamashita, Yukari Tsurudome, Motofumi Kumazoe, Huang, Y., Kanami Nakahara, Yuki Shinoda, Wataru Yamaguchi, Mari Maeda-Yamamoto, Koji Yamada, Hirofumi Tachibana, Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder., Scientific. Reports, 10.1038/srep02749, 3, 2749, 2013.09.
74. Kim, YH., Yoshinori Fujimura, Nagao, T, Takatoki Hagihara, Masako Sasaki, Daichi Yukihira, Daisuke Miura, HIroshi Tanaka, Saito, D., Hiroyuki Wariishi, Koji Yamada, Hirofumi Tachibana, In situ label-free imaging for visualizing biotransformation of bioactive polyphenol., Scientific Reports, 10.1038/srep02805, 3, 2805, 2013.09.
75. Miyamoto, T., Mekada, Y., Kurahachi, M., Umeno, M., Nakayama, M., Shigemune, M., Tsugukuni, T., Tokuda, H., Tachibana, H., and Honjoh, K., A highly sensitive method for quantifying gallocatechin gallate and its epimer using a catechinspecific peptide., Food Cont., 29, 162-166 (2013)., 2013.08.
76. Kim, Y.H., Nakayama, K., Yoshimoto, M., Tanino, S., Koji Yamada, Hirofumi Tachibana, 1,2,3,4,6-penta-O-galloyl-β-D-glucose from tannic acid inhibits antigen-specific IgE production by inhibiting  germline transcription induced by STAT6 activation. , FEBS Open Bio, 10.1016/j.fob.2013.07.008, 2013.08.
77. Kumazoe, M., Kim, Y-H., Tsukamoto, S., Huang, Y., Nakahara, K., Bae, JH., Takai, M., Suemasu, Y., Motoki Murata, Sugihara, K., 山下 修矢, Koji Yamada, Hirofumi Tachibana, Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis.
, FEBS Letter, org/10.1016/j.febslet.2013.07.041, 2013.08.
78. Akira Iwamoto, Yuichi Inoue, Aiko Inoue, Koji Yamada, Hirofumi Tachibana, Hiroharu Kawahara, Anti-allergic effects of strawberry extract, J. Funct. Foods, 5, , 1947-1955, 2013.07.
79. 山崎有美, 山崎正夫, 安藤美子, 立花 宏文, 山田 耕路, オキナワモズク由来フコイダンの細胞運動阻害作用, 日本食品科学工学会誌, 60, 7, 357-361, 2013.07.
80. Kumazoe, M., Sugihara, K., Tsukamoto, S., Huang, Y., Tsurudome, Y., Suzuki, T., Suemasu, Y., Yamashita, S., Kim, Y-H., Koji Yamada, Hirofumi Tachibana, 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis., J.Clin.Invest., 123, 787-799, 2013.02.
81. 村山加奈子, 澤智子, 古賀裕章, 山口智, 熊添基文, 大塚崇文, 宮崎義之, 立花 宏文, 山田 耕路, 不知火姫菊の花弁および葉抽出液のヒト乳がん細胞MCF-7株に対する増殖抑制作用, 日本食品科学工学会誌, 60, 2, 80-86, 2013.02.
82. Lee J.H., Won, Y.S., Park, K.H., Lee, M.K., Hirofumi Tachibana, Koji Yamada, Seo, K.I., Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling., Apoptosis, 17, 1275-1286, 2012.09.
83. Maeda-Yamamoto, M., Saito, T., Nesumi, A., Tokuda, Y., Ema, K., Honma, D., Ogino, A., Monobe, M., Murakami, A., Murakami, A., and Tachibana, H., Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. ‘Sunrouge’)"., J. Sci. Food Agric.92, 2379-2386 (2012)., 2012.08.
84. Maeda-Yamamoto, M., Ema, K., Monobe, M., Tokuda, Y., and Tachibana, H., Epicatechin-3-O-(3-O-methyl) gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release., J. Agric. Food Chem. 60, 2165-2170 (2012), 2012.08.
85. Tsukamoto, S., Yamashita, S., Kim, Y.H., Kumazoe, M., Huang, Y., Koji Yamada, Hirofumi Tachibana, Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG., FEBS Lett., 586, 3441-3447, 2012.08.
86. Koji Yamada, Tomoko Sawa, Kanako Murayama, Satoshi Yamaguchi, Hirofumi Tachibana, 不知火姫菊の花弁および葉抽出液のヒスタミン放出抑制効果, 日本食品科学工学会誌, 59, 8, 394-400, 2012.08.
87. Yamashita, S., Yano, S., Tsukamoto, S., Kumazoe, M., Kim, Y-H., Koji Yamada, Hirofumi Tachibana, Isoflavones suppress the expression of the FcεRI high-affinity IgE receptor independently of estrogen receptor., J. Agric. Food Chem., 60, 8, 8379-8385, 2012.08.
88. Shin Yasuda, Hirofumi Tachibana, Koji Yamada, Induction of nitric oxide generation by various cow milk cheeses in RAW264.7 mouse macrophage-like cells., Milkscience, 61, 89-94, 2012.06.
89. Yamasaki, Y., Yamasaki, M., Tachibana, H., and Yamada, Y. , β-Integrin plays an important role in fucoidan-induced apoptosis via caspase-8 activation., Biosci. Biotechnol. Biochem.,76(6), 1163-1168 (2012)., 2012.06.
90. Yasuda, S., Kuwata, H., Kawamoto, K., Shirakawa, J., Atobe, S., Hoshi, Y.,Yamasaki, M., Nishiyama, K., Tachibana,H., Yamada, K., Kobayashi,H., Igoshi,K. , Effect of Highly Lipolyzed Goat Cheese on HL-60 Human Leukemia Cells: Antiproliferative Activity and Induction of Apoptotic DNA Damage.
, J. Dairy Sci., 95(5), 2248-2260 (2012)., 2012.05.
91. Fujimura, Y., Sumida, M. Sugihara, K., Tsukamoto, S., Yamada, K., and Tachibana, H. , Green Tea Polyphenol EGCG Sensing Motif on the 67-kDa Laminin Receptor., PLoS ONE, e37942, 7(5) (2012)., 2012.05.
92. Tsukamoto, S., Hirotsu, K., Kumazoe, M., Goto, Y., Sugihara, K., Suda, T., Tsurudome, Y., Suzuki, T., Yamashita, S., Kim, Y., Huang, Y., Yamada, K., and Tachibana, H. , Green tea polyphenol EGCG induces lipid raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through 67-kDa laminin receptor in multiple myeloma cells., Biochem. J., 443, 525-534, 2012.02.
93. Kim, Y.H., Ida, M., Yamashita, S., Tsukamoto, S., Kumazoe,M., Sumida, M., Mitsuo Kawakami, M., Yamada, K., and Tachibana, H., Anti-allergic effects of Kakrol (Momordica diocia Roxb.) flesh extract, Bioscience of Microbiota, Food and Health, 31, 1-6 , 2012.01.
94. Maeda-Yamamoto, M., Ema, K., Tokuda, Y., Monobe, M., Tachibana, H., Sameshima, Y., and Kuriyama, S., Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study., Cytotechnology, 63, 171-179, 2011.08.
95. Fujimura, Y., Kurihara, K., Ida, M., Kosaka, R., Miura, D., Wariishi, H., Maeda-Yamamoto, M., Nesumi, A., Saito, T., Kanda, T., Yamada, K., and Tachibana, H., Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars, PLoS ONE, 585, e23426, 6(8), 2011.05.
96. Byun, E.-H., Omura, T., Yamada, K., and Tachibana, H. , Green tea polyphenol epigallocatechin-3-gallate inhibites TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor., FEBS Lett., 585, 814-820, 2011.03.
97. Maeda-Yamamoto M, Ema K, Tokuda Y, Monobe M, Tachibana H, Sameshima Y, Kuriyama S., Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study.
, Cytotechnology, 2011.02.
98. Miura, D., Fujimura, Y., Yamato, M., Hyodo, F., Tachibana, H., and Wariishi, H., Ultra-highly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors., Anal. Chem., 82, 9789-9796, 2010.12.
99. Tanaka H., Yamanouchi M., Miyoshi H., Hirotsu K., Tachibana H., and Takahashi T., Solid-phase synthesis of a combinatorial methylated epigallocatechin gallate library and their growth inhibitory effects on melanoma B16 cells., Chem. Asian J., 5, 10, 2231-2248, 2010.10.
100. Yamashita, S., Yamada, K. and Tachibana, H., Identification of a Sensing Gene for Antioxidative Flavones., Free Radic. Biol. Med., 49, Supplement1, S151, 2010.10.
101. Miura, D., Fujimura, Y., Hyodo, F., Yasukawa, K., Tachibana, H., and Wariishi, H., Analysis of Cisplatin-Induced Nephrotoxicity by In Situ Mass Spectrometry Imaging and Urinary Metabolic Profiling., Free Radic. Biol. Med., 49, Supplement1, S191, 2010.10.
102. Fujimura, Y., Tsukamoto, S., Irie, M., Miura, D., Wariishi, H., and Tachibana, H., New Insights into Anticancer Effect of Green Tea Polyphenol Epigallocatechin-3-gallate in Hypoxia by Metabolic Profiling., Free Radic. Biol. Med., 49, Supplement1, S220, 2010.10.
103. Lee JH., Kishikawa M., Kumazoe M., Yamada K., and Tachibana H., Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa Laminin Receptor., PLoS ONE, 5, 6, e11051, 2010.06.
104. Kanouchi H., Shibuya M., Tsukamoto S., Fujimura Y., Tachibana H., Yamada K.,and Oka T., Comparisons of uptake and cell surface binding among pyridoxal, pyridoxine and pyridoxamine in RAW264.7 cells., Nutrition, 6, 6, 648-652, 2010.06.
105. Byun E-H., Fujimura Y., Yamada K., and Tachibana H., TLR 4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor., J. Immunol., 185, 33-45, 2010.06.
106. Yamashita, S., Yamashita, T., Yamada, K., and Tachibana, H., Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain., FEBS Lett., 587, 775-779, 2010.03.
107. Kurihara K., Nagatomo S., Maeda-Yamamoto M., Yamada K., and Tachibana H., Inhibitory effect on thrombin-induced myosin light chain phosphorylation by an extract of new green tea cultivar in A7r5 rat aortic smooth muscle cells., Food Sci. Tech. Res., 16, 3, 263-266, 2010.03.
108. Kurita, I., Maeda-Yamamoto, M., Tachibana,. H., and Kamei, M., Antihypertensive effect of Benifuuki tea containing O-methylated EGCG, J. Agric. Food Chem., 58, 1903-1908, 2010.02.
109. Miura, D., Fujimura, Y., Tachibana, H., and Wariishi, H., Highly Sensitive MALDI-Mass Spectrometry for High-throughput Metabolic Profiling, Anal. Chem., 82, 18, 498-504, 2010.01.
110. Hiura, Y., Tachibana, H., Arakawa, R., Aoyama, N., Okabe,M., Sakai, M. and Yamada,K., Specific accumulation of γ and δ-tocotrienols in tumor and their antitumor effect in vivo, J. Nutr. Biochem., 20, 607-613, 2009.07.
111. Yano, S., Umeda, D., Yamashita, S., Yamada, K. and Tachibana, H., Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice, J. Nutr. Biochem., 20, 876-881, 2009.07.
112. Lee, J-H., Tachibana, H., Morinaga, Y., Fujimura, Y., and Yamada, K., Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids., Life Sciences, 84, 415-420, 2009.07.
113. Yamasaki-Miyamoto, Y., Yamasaki, M., Tachibana, H., and Yamada, K., Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 Cells, J. Agri. Food Chem., 57, 18, 8766-8782, 2009.07.
114. Maruyama, S., Akasaka, T., Yamada, K., and Tachibana, H., Cistanche salsa extract acts similarly to protein-bound polysaccharide-K (PSK) on various types of cell lines., J. Trad. Med., 25, 166-169, 2009.05.
115. Maruyama, S., Akasaka, T., Yamada, K., and Tachibana, H., Bioactivity of High-molecular-weight Constituents of Cistanche tubulosa, Pharmacologyonline, 1, 913-921, 2009.01.
116. Yamasaki, M, Tachibana, H, Yamada, A, Ochi, Y, Madhyastha, H, Nishiyama ,K, Yamada, K., Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway, In Vitro Cellular & Developmental Biology –Animal, 44, 290-294 (2008), 2008.09.
117. Umeda, D., Yamada, K., and Tachibana, H., H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation, Eur. J. Pharm., 590, 61-66, 2008.09.
118. Umeda, D., Yano, S., Yamada, K., and Tachibana, H., Identification of Eukaryotic Translation Elongation Factor 1A as a Downstream Mediator of EGCG Signaling through 67-kDa Laminin Receptor., J. Clin. Biochem. Nutr., 43 Suppl. 1, 113-116, 2008.09.
119. Yano, S., Fujimura, Y., Umeda, D., Miyase, T., Yamada, K., Tachibana, H., Relationship between the suppressive effect of methylated derivatives of EGCG on FcεRI Expression and their cell surface binding activities., J. Clin. Biochem. Nutr., 43 Suppl. 1, 473-476, 2008.09.
120. Fujimura, Y., Umeda, D., Maeda-Yamamoto, M., Yamada,K.and Tachibana, H., The 67 kDa laminin receptor mediates anti-allergic effects of epigallocatechin-3-O-(3-O-methyl) gallate., J. Clin. Biochem. Nutr., 43 Suppl. 1, 477-480, 2008.09.
121. Fujimura, Y., Umeda, D., Yamada, K., and Tachibana, H., The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins, Arch. Biochem. Biophys. , 476 (2), 133-138, 2008.07.
122. Umeda, D., Yano, S., Yamada, K., and Tachibana, H., Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells, Biochem. Biophys. Res. Commun., 371, 172-176, 2008.06.
123. Maruyama, S., Yamada, K., and Tachibana, H., Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1, Biomedicine and Pharmacotherapy , 63, 6, 409-412, 2008.06.
124. Maruyama, S., Yamada, K., and Tachibana, H., Immunomodulating activity of Cistanche salsa, J. Trad. Med.
, 25, 87-89, 2008.06.
125. Umeda, D., Yano, S., Yamada, K., and Tachibana, H., Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor, J. Biol. Chem., 283, 3050-3058, 2008.02.
126. Maruyama, S., Yamada, K., and Tachibana, H., Cistanche salsa extract induced apoptosis in the human Burkitt’s lymphoma cell clone Namalwa, J. Trad. Med.
, 25, 24-27, 2008.01.
127. Miyamoto-yamasaki, Y. Yamasaki, M. Tachibana, H. Yamada, K., Induction of endoreduplication by a JNK Inhibitor SP600125 in human lung carcinoma A 549 cells, Cell Biology Int., 31, 12, 1501-1506 , 2007.12.
128. Maruyama, S., Yamada, K., and Tachibana, H., Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1, J. Trad. Med., 24, 209-211, 2007.12.
129. Miyamoto-yamasaki, Y. Yamasaki, M. Tachibana, H. Yamada, K., Induction of endoreduplication by a JNK Inhibitor SP600125 in human lung carcinoma A 549 cells., Cell Biology Int., 31(12), 1501-1506, 2007.11.
130. Fujimura, Y., Umeda, D., Yano, S., Maeda-Yamamoto, M., Yamada, K., and Tachibana, H., The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG, Biochem. Biophys. Res. Commun., 364, 79-85, 2007.10.
131. Tachibana, H., Yano, S., and Yamada, K. , Study on the molecules involved in anti-allergic effect of soybean components
, Soy Protein Res., , 10, 128-133, 2007.06.
132. Nakaya, M., Onda, Y., Yukiyoshi, A., Tachibana, H., and Yamada K., Effect of royal jerry on bisphenol A-induced proliferation of human breast cancer cells, Biosci. Biotechnol. Biochem., 71, 253-255, 2007.05.
133. Yano, S., Umeda, D., Yamashita, T., Ninomiya, Y., Sumida,M., Fujimura, Y., Yamada, K., and Tachibana, H., Dietary flavones suppress IgE and Th2 cytokines in OVA-immunized BALB/c mice, Eur J. Nutr., 46, 5, 257-263, 2007.05.
134. Ikeda, Y., Murakami, M., Fujimura, Y., Tachibana, H., Yamada, K., Hirano, K., Masuda, D., Ohigashi, H., The aggregated ursolic acid, a natural triterpenoid, induces interleukin-1β release in murine peritoneal macrophages: A role of CD36, J. Immunol., 178, 4854-4864, 2007.04.
135. Yano, S., Fujimura, Y., Umeda, D., Miyase, T., Yamada, K, and Tachibana,H. , Relationship between biological activities of methylated derivatives of EGCG and their cell surface binding activities, J. Agric. Food Chem., 55, 17, 7144-7148, 2007.03.
136. 柘植圭介、渡部弥生、前田徳秀、阿部真一、鶴橋亨、吉村臣史、吉木政弘、立花宏文、山田耕路, スサビノリ水溶性低分子画分のHL-60細胞の増殖に及ぼす影響, 日本食品科学工学会誌, 54, 2, 241-246, 2007.02.
137. Maeda, N., Yoshimi, K., Tachibana, H., and Yamada, K., Soy-derived immunoglobulin production stimulating factor enhances IgM production of mouse spleen lymphocytes, J. Food Sci., 71, 643-647 , 2006.12.
138. Fujimura,Y., Yamada, K., and Tachibana, H., The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate, Biochem. Biophys. Res. Commun., 348, 524-531 , 2006.11.
139. Sakai, M., Okabe, M., Tachibana, H., and Yamada, K. , Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells, J Nutr Biochem. , 17, 672-676 , 2006.10.
140. Nakaya, M., Onda, Y., Yukiyoshi, A., Tachibana, H., and Yamada K., Effect of royal jerry on bisphenol A-induced proliferation of human breast cancer cells, Biosci. Biotechnol. Biochem., 71, 253-255 , 2006.08.
141. Yamasaki M, Kitagawa T, Koyanagi N, Chujo H, Maeda H, Kohno-Murase J, Imamura J, Tachibana H, Yamada K., Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice, Nutrition, 22, 54-59 , 2006.06.
142. Nakaya, M., Tachibana, H., and Yamada, K., Effect of estrogens on interferon-γ producing cell population of mouse splenocytes, Biosci. Biotechnol. Biochem., 70, 47-53 , 2006.05.
143. Yano, S., Umeda, D., Maeda, N., Fujimura, Y., Yamada, K., and Tachibana,H., Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice, J. Agric. Food Chem, 54, 5203-5207 , 2006.05.
144. Yasuda, S., Wu, P.-O., Okabe, M., Tachibana, H. and Yamada K., Tissue-specific distribution of genistein, daizein and bisphenol A in male Sprague-Dawley rats after intragastric administration, Food Sci. & Tech. Res., 10.3136/fstr.11.187, 11, 2, 187-193, 11, 187-193 , 2005.10.
145. Fujimura,Y., Yamada, K., and Tachibana, H., A lipid raft-associated 67 kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcεRI expression , Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.08.146, 336, 2, 674-681, 348, 524-531 , 2005.08.
146. Nakaya, M., Tachibana, H., and Yamada, K., Isoflavone genestein and daizein up-regulate LPS-inducible oxide synthase activity through estrogen receptor pathway in RAW264.7 cells, Biochem. Pharmacol., 10.1016/j.bcp.2005.10.002, 71, 1-2, 108-114, 71, 108-114 , 2005.06.
147. Umeda, D., Tachibana, H, and Yamada, K., Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67kDa laminin receptor, Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.05.108, 333, 2, 628-635, 336, 674-681 , 2005.06.
148. Nakaya, M., Yamasaki, M., Tachibana, H., and Yamada, K., IgM production of lymphocytes from C57BL/6N mice was stimulated by estrogen treated splenic adherent cells, Immunol. Lett., 10.1016/j.imlet.2004.11.023, 98, 2, 225-231, 98, 225–231 , 2005.02.
149. Yamasaki, M, Miyamoto, Y, Chujo, H, Nishiyama, K, Tachibana,H, Yamada, K, Trans10,cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilizationinrat hepatoma cells , Biochim Biophys Acta, 10.1016/j.bbalip.2005.05.010, 1735, 3, 176-184, 1735, 176-184 , 2005.02.
150. Yano, S., Tachibana, H., and Yamada, K., Flavones suppress the expression of the high affinity IgE receptor FcεRI in human basophilic KU812 cells, J. Agric. Food Chem, 10.1021/jf047929d, 53, 5, 1812-1817, 53, 1812-1817 , 2005.02.
151. Yamasaki, M., Nishida, E., Nou, S., Tachibana, H., and Yamada, K., Cytotoxity of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol, In Vitro Cell. Dev. Biol., 41, 239-244 , 2005.01.
152. Tachibana, H., Koga, K., Fujimura, Y., and Yamada, K., A receptor for green tea polyphenol EGCG, Nature Struc. Mol. Biol., 10.1038/nsmb743, 11, 4, 380-381, 11, 380-381, 2004.04.
153. Maeda-Yamamoto, M., Inagaki, N., Kitaura, J., Chikumoto, T., Kawahara, H., Kawakami,Y., Sano, M., Miyase, T., Tachibana, H., Nagai, H., and Kawakami, T., O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells, J. Immunol.,, 172, 7, 4486-4492, 172, 4486-4492, 2004.04.
154. Fujimura, Y., Tachibana, H., and Yamada, K., Lipid raft-associated catechin suppresses the FceRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2, FEBS Lett., 10.1016/S0014-5793(03)01432-7, 556, 1-3, 204-210, 556, 204-210, 2004.01.
155. Nakaya, M., Yamasaki, M., Miyazaki, Y., Tachibana, H., Yamada, K., Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction., In Vitro Cell Dev Biol Anim., 39, 8-9, 383-387, 2003.10.
156. Chujo, H., Yamasaki, M., Koyanagi, N., Iwara, T., Tsutsumi, K., Tachibana, H., and Yamada, K., Inhibitory effect of conjugated linoleic acid isomaers on the proliferation of human breast cancer cells., Cancer letter, 202, 81-87, 2003.10.
157. Yamada, K., Tokunaga, Y., Ikeda, A., Ohkura, K., Kaku-Ohkura, S., Mamiya, S., Lim, B.-O., and Tachibana, H., Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats., Biosci. Biotechnol. Biochem., 67, 2, 429-433, 67, 429-43, 2003.09.
158. Yamasaki, M., Chujo, H., Nou, S., Tachibana, H., and Yamada, K., Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid., Cancer lett., 10.1016/S0304-3835(03)00215-5, 196, 2, 187-196, 196, 187-196, 2003.04.
159. 立花宏文、藤村由紀、矢野和美、山田耕路, 大豆サポニンの高親和性IgE受容体発現抑制効果, 大豆たん白質研究, 6, 104-107, 2003.04.
160. Liu, Z., Otonari, M., Naito, S., Yasuda, S., Tanaka, H., Yoshioka, H., Oyabu, M., Tobina, T., Kanda, R., Tanaka, H., Shindo, M., Tachibana, H., and Yamada, K., Diurnal variation in secretory immunoglobulin A concentration., J. Fac. Agr. Kyushu Univ., 48, 1-2, 167-174, 48, 1-11, 2003.03.
161. Yamasaki, M., Ikeda, A., Oji, M., Tanaka, Y., Hirao, A., Kasai, M., Iwata, T., Tachibana, H., and Yamada, K., Modulation of body fat and serum leptin levels by dietary conjugated  linoleic acid in Sprague-Dawley rats fed various fat level diets., Nutrition, 10.1016/S0899-9007(02)00842-0, 19, 1, 30-35, 19, 30-35, 2003.01.
162. Yamasaki, M., Chujo, H., Hirao, A., Koyanagi, N., Okamoto, T., Tojo, N., Oishi, A., Iwata, T., Yamauchi-Sato, Y., Yamamoto, T., Tsutsumi , K., Tachibana, H., and Yamada, K., Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid., J. Nutr., 133, 3, 784-788, 133, 784-788, 2003.01.
163. Fujimura, Y., Tachibana, H., and Yamada, K., Peroxisome proliferator-activated receptor (PPAR) ligands negatively regulate the expression of the high-affinity IgE receptor FceRI in human basophilic KU812 cells., Biochem. Biophys. Res. Commun, 10.1016/S0006-291X(02)02139-3, 297, 2, 193-201, 297, 193-201, 2002.09.
164. Miyazaki, Y., Tachibana, H., and Yamada, K., Inhibitory effect of peroxisome proliferator-activated receptor-g ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39., Biochem. Biophys. Res. Commun., 10.1016/S0006-291X(02)00709-X, 295, 2, 547-552, 295, 547-552, 2002.08.
165. Fujimura, Y., Tachibana, H., Maeda-Yamamoto, M., Miyase, T., Sano, M., and Yamada, K., Antiallergic tea catechin, (-)-Epigallocatechin-3-O-(3-O-methyl) gallate, suppresses FceRI expression in human basophilic KU812 cells., J. Agric. Food Chem., 10.1021/jf025680z, 50, 20, 5729-5734, 50, 5729-5734, 2002.07.
166. Han, D.-H., Denison M. S., Tachibana, H., and Yamada, K., Relationship between estrogen receptor-binding and estrogenic activites of environmental estrogens and suppression by flavonoids, Biosci. Biotechnol. Biochem, 66, 7, 1479-1487, 66,1479-1487, 2002.07.
167. Yamada, K., Okabe, M., Ohkura, K., Oji, M., Nonaka, M., Ikeda, I., and Tachibana, H., Dietary effect of a-tocopherol and tocotrienols on lipid metaborism and immune function of aged Sprague-Dawley rats., Food Sci. Technol. Res., 10.3136/fstr.8.59, 8, 1, 59-63, 8, 59-63, 2002.01.
168. Okamoto, T., Sugahara, T., Tachibana, H., and Yamada, K., Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone, Biosci. Biotechnol. Biochem, 66, 6, 1241-1245, 66, 1241-1245, 2002.01.
169. Okabe, M., Oji, M., Ikeda, I., Tachibana, H., and Yamada, K., Tocotrienol levels in various tissues of Sprague-dawley rats after intragastric administration of tocotrienols., Biosci. Biotechnol. Biochem, 66, 8, 1768-1771, 66, 1768-1771, 2002.01.
170. Han, D., Denison, M. S., Tachibana, H., and Yamada, K., Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes, Biol. Pharm. Bull., 10.1248/bpb.25.1263, 25, 10, 1263-1267, 25, 1263-1267, 2002.01.
171. Yamasaki, M., Chujo, H., Koga, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K., Potent cytotoxic effect of trans-10, cis-12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells., Cancer Lett., 10.1016/S0304-3835(02)00459-7, 188, 1-2, 171-180, 188, 171-180, 2002.01.
172. Yamasaki, M., Ikeda, A., Tanaka, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K., Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo, J. Nutr. Sci. Vitaminol., 48, 6, 505-511, 48, 505-511, 2002.01.
173. Fujimura, Y., Tachibana, H., and Yamada, K., A tea catechin suppresses the expression of the high affinity IgE receptor FceRI in the human basophilic KU812 cells., J. Agric. Food Chem., 10.1021/jf001392w, 49, 5, 2527-2531, 49, 2527-2531, 2001.10.
174. Takasugi, M., Tamura, Y., Tachibana, H., Sugano, M., and Yamada, K., Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes., Biosci. Biotechnol. Biochem, 10.1271/bbb.65.143, 65, 1, 143-149, 65, 143-149, 2001.01.
175. Kaku, S., Yunoki, S., Ohkura, K., Sugano, M., Nonaka, M., Tachibana, H., and Yamada, K., Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats, Biosci. Biotechnol. Biochem, 10.1271/bbb.65.315, 65, 2, 315-321, 65, 315-321, 2001.01.
176. Han, D-H., Tachibana, H., and Yamada, K., Interaction of flavonoids and environmental estrogens on proliferation of human breast carcinoma MCF-7 cells., In Vitro Cell. Devlop. Biol., 37, 275-282, 2001.01.
177. Yamasaki, M., Ikeda, A., Hirao, A., Tanaka, Y., Miyazaki, Y., Rikimaru, T., Shimada, M., Sugimachi, K., Tachibana, H., and Yamada, K., Effect of dietary conjugated lonoleic acid on the in vivo growth of rat hapatoma dRLh84., Nut. Cancer, 10.1207/S15327914NC402_10, 40, 2, 140-148, 40, 140-148, 2001.01.
178. Miyazaki, Y., Tokunaga, Y., Takagaki, K., Tsuzaki, S., Tachibana, H., and Yamada, K., Effect of dietary cabbage fermentation extract and young barley leaf powder on immune function of sprague-Dawley rats., J. Nutr. Sci. Vitaminol., 47, 3, 253-257, 47, 253-257, 2001.01.
179. Kaku, S., Ohkura, K., Yunoki, S., Nonaka, M., Tachibana, H., Sugano, M., and Yamada, K., Dietary g-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats, Prostaglandins Leukot Essent Fatty Acids, 10.1054/plef.2001.0312, 65, 4, 205-210, 65, 205-210, 2001.01.
180. Miyazaki, Y., Yamasaki, M., Mishima, H., Mansho, K., Tachibana, H., and Yamada, K., Oxidation of cell membrane phospholipids suppresses immunoglobulin production by mouse spleen lymphocytes., Biosci. Biotechnol. Biochem, 65, 593-598, 2001.01.
181. Tachibana, H., Kubo, T., Miyase, T., Tanino, S., Yoshimoto, M., Sano, M., Yamamoto-Maeda, M., and Yamada, K., Identification of an inhibitor for interleukin 4-induced e germline transcription and antigen-specific IgE production in vivo., Biochem. Biophys. Res. Commun., 10.1006/bbrc.2000.4069, 280, 1, 53-60, 280, 53-60, 2001.01.
182. Kanouchi, H., Tachibana, H.,Oka, T., and Yamada, K., Recombinant expression of perchloric acid-solble protein reduces cell proliferation., Cell. Mol. Life Sci., 10.1007/PL00000945, 58, 9, 1340-1343, 58, 1340-1343, 2001.01.
183. 山本(前田)万里、佐野満昭、松田奈帆美、宮瀬敏男、川本恵子、鈴木直子、吉村昌恭、立花宏文、袴田勝弘, 茶の品種、摘採期と製造法による抗アレルギー性カテキンEGCG3モMeの変動., 日本食品科学工学会誌, 48, 64-68, 2001.01.
184. Fujimura, Y., Tachibana, H., Eto, M., and Yamada, K, Antigen binding of an ovomucoid specific monoclonal antibody is modulated by the carbohydrate chain on the light chain variable region., Biosci. Biotech. Biochem, 10.1271/bbb.64.2298, 64, 11, 2298-2305, 64 2298-2305, 2000.11.
185. Tachibana, H., Haruta, H., Ueda, K., Chiwata, T. and Yamada, K., Induction of light chain replacement in human plasma cells by caffeine independent from enhancement of RAG proteins expression and germ-line transcription., J. Biol. Chem., 10.1074/jbc.275.8.5927, 275, 8, 5927-5933, 275, 5927-5933, 2000.08.
186. Yamasaki, M., Kishihara, K., Mansho, K., Ogino, Y., Kasai, M., Tachibana, H., and Yamada, K., Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes, Biosci. Biotechnol. Biochem, 10.1271/bbb.64.2159, 64, 10, 2159-2164, 64, 2155-2160, 2000.10.
187. Tachibana, H., Sunada, Y., Miyase, T., Sano, M., Maeda-Yamamoto, M., and Yamada, K., Identification of a methylated epigallocatechin gallate as an inhibitor of degranulation in human basophilic KU812 cells., Biosci. Biotech. Biochem, 64, 452-454, 2000.11.
188. Yamasaki, M., Mansho, K., Ogino, Y., Kasai, M., Tachibana, H., and Yamada, K., Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats., J. Nutr. Biochem., 10.1016/S0955-2863(00)00116-9, 11, 9, 467-471, 11, 467-471, 2000.01.
189. Yamasaki, M., Mansho, K., Mishima, H., Kimura, G., Sasaki, M., Kasai, M., Tachibana, H., and Yamada, K., Effect of dietary conjugated linoleic acid on lipid peroxidation and histological change in rat liver tissues, J. Agric. Food Chem., 10.1021/jf9912001, 48, 12, 6367-6371, 48, 6367-6371, 2000.01.
190. Hung, P., Gu, J-Y., Kaku, S., Yunoki, S., Ohkura, K., Ikeda, I., Tachibana, H., Sugano, M., Yazawa, K., and Yamada, K., Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in sprague-dawley rats, Biosci. Biotechnol. Biochem, 64, 2588-2593, 2000.01.
191. Yamada, K., and Tachibana, H., Recent topics in antioxidative factors., BioFactors, 13, 1-4, 167-172, 13, 167-172, 2000.01.
192. Kanouchi, H., Oka, T., Asagi, K., Tachibana, H., and Yamada, K., Expression and cellular distribution of perchloric acid-soluble protein is dependent on the cell-proliferating States of NRK-52E cells., Cell. Mol. Life Sci., 10.1007/PL00000746, 57, 7, 1103-1108, 57, 11103-1108, 2000.01.
193. Hara, T., Tachibana, H., and Yamada, K., Basophilic differentiation of the human leukemia cell line KU812 upon treatment with hydrocortisone., Cytotechnology., 34, 213-223, 2000.01.
194. Tachibana, H., Haruta, H. and Yamada, K., Light Chain Shifting: Identification of a human plasma cell line actively undergoing light chain replacement., Blood, 93, 1, 198-207, 93, 198-207, 1999.04.
195. Yamada, K., Tachibana, H., Matsuo, N., Nishiyama, K., and Sugano, M., Structure-activity relationship of immunoregulatory factors in foodstuffs., Food Sci. Technol. Res., 5, 1-8, 1999.01.
196. Yamasaki, M., Mansho, K., Mishima, H., Kasai, M., Sugano, M., Tachibana, H., and Yamada K, Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats., Biosci. Biotechnol. Biochem., 10.1271/bbb.63.1104, 63, 6, 1104-1106, 63, 1104-1106, 1999.01.
197. Yamada K., Tokunaga Y., Ikeda A., Ohkura, K., Mamiya S., Kaku S., Sugano M., and Tachibana H., Dietary effect of guar gum and its partially hydrolyzed product on lipid metabolism and immune function of Sprague-Dawley rats., Biosci. Biotechnol. Biochem., 10.1271/bbb.63.2163, 63, 12, 2163-2167, 63, 2163-2167, 1999.01.
198. Haruta, T., Tachibana, H. and Yamada, K., Concanavalin A stimulation enhanced secondary VlJl rearrangement in some human plasma B cells without up-regulation of recombination activating gene expression and Vl germline transcription., Immunology, 97, 4, 549-557, 97, 549-557, 1999.01.
199. Kuramoto T, Miyazaki Y, Inoue S, Haruta H, Tachibana H, Sugano M and Yamada K, Effect of rosebengal on immunoglobulin production by mouse B lymphoma, WEHI-279 cells., J. Agric. Food Chem., 10.1021/jf9804793, 46, 12, 5368-5372, 46, 5368-5372, 1998.01.
200. Hara, T., Yamada, K. and Tachibana, H., Basophilic differentiation of the human leukemia cell line KU812 upon treatment with interleukin-4., Biochem. Biophys. Res. Commun., 10.1006/bbrc.1998.8816, 247, 3, 542-548, 247, 542-548, 1998.07.
201. Haruta, H., Tachibana, H. and Yamada, K., Serum starvation induced secondary VlJl rearrangement in a human plasma B cell., Mol. Immunol., 10.1016/S0161-5890(99)00028-0, 36, 3, 177-185, 36, 177-185, 1999.01.

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