| Mitsuru Tanaka | Last modified date：2024.04.04 |
Associate Professor /
Department of Bioscience and Biotechnology /
Faculty of Agriculture
Papers
| 1. | Tanaka, Mitsuru; Arima, Keishiro; Ide, Haruna; Koshi, Mariko; Ohno, Naoto; Imamura, Miho; MATSUI, Toshiro, Application of graphite carbon black assisted-laser desorption ionization-mass spectrometry for soy sauce product discrimination, Bioscience, Biotechnology, and Biochemistry, https://doi.org/10.1093/bbb/zbae034, 2024.04. |
| 2. | Cheng L, Shi C, Nakamura S, Esaki N, Ichiba Y, Tanaka M, Sakai K, Matsui T, Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells, Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.3c07821, 2024.03. |
| 3. | Lihong Cheng*, Mitsuru Tanaka*, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu & Toshiro Matsui (equal contribution), A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration, Scientific Reports, https://doi.org/10.1038/s41598-023-44161-z, 13, 16908, 2023.10. |
| 4. | Mitsuru Tanaka,* Keishiro Arima, Tomotaka Takeshita, Yuri Kunitake, Naoto Ohno, Miho Imamura, and Toshiro Matsui (*Corresponding author), Laser Desorption Ionization−Mass Spectrometry with Graphite Carbon Black Nanoparticles for Simultaneous Detection of Taste- and Odor-Active Compounds, ACS Applied Nano Materials, doi.org/10.1021/acsanm.1c03890, 5, 2187−2194, 2022.01, There is no analytical system to directly and simultaneously detect taste- and odor-active compounds. Graphite carbon black (GCB) nanoparticles, a chemical adsorbent for a variety of compounds, including gaseous molecules, which consists of nanoparticles made from multilayered sheets of sp2-conjugated atomic carbon, have the characteristics required for a surface-assisted laser desorption ionization–mass spectrometry (SALDI-MS) material. Thus, in this study, GCB-LDI-MS was developed for the simultaneous detection of taste- and odor-active compounds. The proposed GCB-LDI-MS successfully detected volatile compounds, including ethyl esters, alcohols, fatty acids, and aldehydes with up to 16 carbons (maximum carbon number of the tested compounds), which could not be detected by conventional matrix-assisted-LDI-MS. Moreover, a series of taste-active compounds (e.g., amino acids and sugars) and various volatile compounds (e.g., ethyl esters, aldehydes, alcohols, fatty acids, and lactones) as a mixture in liquid samples were also detected by the present GCB-LDI-MS. Thus, the proposed simple and rapid detection technique can digitize the analysis of flavor compounds, which provides an analytical concept for flavor scanning to evaluate the palatability of food products.. |
| 5. | Tae Hun Hahm, Toshiro Matsui*, and Mitsuru Tanaka* (*Corresponding author), Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Tissues via the Formation of Reproducible Matrix Crystals by the Fluorescence-Assisted Spraying Method: A Quantification Approach, Analytical Chemistry, DOI: 10.1021/acs.analchem.1c03369, 94, 1990-1998, 2022.01.  |
| 6. | Xiaojing Sheng*, Mitsuru Tanaka*, Risa Katagihara, Marika Hashimoto, Satoshi Nagaoka, Toshiro Matsui (*equal contribution), Novel Approach for Simultaneous Analysis of Peptide Metabolites from Orally Administered Glycinin in Rat Bloodstream by Coumarin-Tagged MALDI–MS, Journal of Agricultural and Food Chemistry, DOI: 10.1021/acs.jafc.1c05791, 69, 49, 14840–14848, 2021.12. |
| 7. | Weilin SHEN, Kiyomi ONO, Mitsuru TANAKA, Toshiro MATSUI, Characteristics of Electrospray-Ionization Detection of Synthetic Di- to Penta-Oligopeptides by Amine Derivatizations, Analytical Sciences, 10.2116/analsci.21N016, 37, 11, 1629-1632, 2021.11. |
| 8. | Kazunori Nakagawa , Mitsuru Tanaka , Tae Hun Hahm , Huu-Nghi Nguyen , Toshiro Matsui , Yong-Xiang Chen , Yutaka Nakashima, Accumulation of Plasma-Derived Lipids in the Lipid Core and Necrotic Core of Human Atheroma: Imaging Mass Spectrometry and Histopathological Analyses, Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.121.316154, 41, 11, e498-e511, 2021.09. |
| 9. | Reiko Nakao, Weilin Shen, Yasuka Shimajiri, Kumiko Kainou, Yuki Sato, Anayt Ulla, Kohta Ohnishi, Miyuki Ninomiya, Ayako Ohno, Takayuki Uchida, Mitsuru Tanaka, Kazuhito Akama, Toshiro Matsui & Takeshi Nikawa , Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle, npj Science of Food , https://doi.org/10.1038/s41538-021-00108-0, 5, Article number 25, 1-10, 2021.09. |
| 10. | Mitsuru Tanaka, Hayato Kiyohara, Atsuko Yoshino, Akihiro Nakano, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka, Toshiro Matsui, Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice, npj Science of Food, 10.1038/s41538-020-0067-3, 4, 1, 2020.12. |
| 11. | Tae Hun Hahm*, Mitsuru Tanaka*, Huu-Nghi Nguyen, Ayaka Tsutsumi, Koichi Aizawa, Toshiro Matsui (*equal contribution), Matrix-assisted laser desorption/ionization mass spectrometry-guided visualization analysis of intestinal absorption of acylated anthocyanins in Sprague-Dawley rats, Food Chemistry, doi.org/10.1016/j.foodchem.2020.127586., 334, 1, 127586, 1-9, 2020.07, [URL]. |
| 12. | Mitsuru Tanaka, Chung Hsuan, Masataka Oeki, Weilin Shen, Asuka Goda, Yusuke Tahara, Takeshi Onodera, Keisuke Sanematsu, Tomotsugu Rikitake, Eiji Oki, Yuzo Ninomiya, Rintaro Kurebayashi, Hideto Sonoda, Yoshihiko Maehara, Kiyoshi Toko, Toshiro Matsui, Identification of characteristic compounds of moderate volatility in breast cancer cell lines, PLOS ONE, https://doi.org/10.1371/journal.pone.0235442, 15, 6, e0235442, 2020.06. |
| 13. | Mitsuru Tanaka, Shinya Dohgu, Genki Komabayashi, Hayato Kiyohara, Fuyuko Takata, Yasufumi Kataoka, Takashi Nirasawa, Motohiro Maebuchi & Toshiro Matsui, Brain-transportable dipeptides across the blood-brain barrier in mice, Scientific Reports, https://doi.org/10.1038/s41598-019-42099-9, 9, 5769, 1-10, 2019.04. |
| 14. | Huu-Nghi Nguyen*; Tanaka, Mitsuru*; Li, Baorui; Ueno, Tomoya; Matsuda, Hideki; Matsui, Toshiro (*These authors contributed equally), Novel in situ visualisation of rat intestinal absorption of polyphenols via matrix-assisted laser desorption/ionisation mass spectrometry imaging, SCIENTIFIC REPORTS, 10.1038/s41598-019-39405-w, 9, 3166, 1-9, 2019.02. |
| 15. | Ayano Shimizu, Takakazu Mitani, Sachi Tanaka, Hiroshi Fujii, Motohiro Maebuchi, Yusuke Amiya, Mitsuru Tanaka, Toshiro Matsui, Soichiro Nakamura, Shigeru Katayama, Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.8b01581, 66, 30, 7935-7941, 2018.08. |
| 16. | Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui, Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b01727, 65, 29, 5935-5943, 2017.07. |
| 17. | Huu Nghi Nguyen*, Mitsuru Tanaka*, Genki Komabayashi, Toshiro Matsui (*equal contribution), The photobase generator nifedipine as a novel matrix for the detection of polyphenols in matrix-assisted laser desorption/ionization mass spectrometry, Journal of Mass Spectrometry, 10.1002/jms.3805, 51, 10, 938-946, 2016.10. |
| 18. | Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Satoshi Tajiri, Mitsuru Tanaka, Yoshinori Mine, Matsui Toshiro, Adenine attenuates the Ca2+ contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells, Naunyn-Schmiedeberg's Arch Pharmacol, 10.1007/s00210-016-1264-0, 289, 999-1007, 2016.09. |
| 19. | Thanutchaporn Kumrungsee, Sayaka Akiyama, Jian Guo, Mitsuru Tanaka, Matsui Toshiro, Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, Food Chemistry, dx.doi.org/10.1016/j.foodchem.2016.06.059, 213, 329-335, 2016.07. |
| 20. | Akiko Mizokami, Wang DaGuang, Mitsuru Tanaka, Gao Jing, Hiroshi Takeuchi, Matsui Toshiro, Hirata Masato, An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration., Bioscience, Biotechnology, and Biochemistry, 10.1080/09168451.2016.1214530, 11, 2176-2183, 2016.07. |
| 21. | Seong-Min Hong, Mitsuru Tanaka, Riho Koyanagi, Weilin Shen, Toshiro Matsui, Structural Design of Oligo-peptides for Intestinal Transport Model, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.6b00279., 64, 10, 2072-2079, 2016.03. |
| 22. | Kazuki Moriyasu, Takashi Ichinose, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya, The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem, International Journal of Peptides, http://dx.doi.org/10.1155/2016/6020786, 2016, 6020786, 1-5, 2016.02. |
| 23. | Vu Thi Hanh, Yutaro Kobayashi, Motohiro Maebuchi, Toshihiro Nakamori, Mitsuru Tanaka, Toshiro Matsui, Quantitative mass spectrometric analysis of dipeptides in protein hydrolysate by a TNBS derivatization-aided standard addition method, Food Chemistry, doi.org/10.1016/j.foodchem.2015.05.053, 190, 345-350, 2016.01. |
| 24. | Yusuke Ushida, Chutinan Boonyapichest, Hiroyuki Suganuma, Mitsuru Tanaka, Toshiro Matsui, Paracellular Transport of Sulforaphane Across Caco-2 Cell Monolayers, Food Science and Technology Research, doi: 10.3136/fstr.22.127, 22, 1, 127-134, 2016.01. |
| 25. | Jian Zhao, Aki Suyama, Hsuan Chung, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui, Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells, Life Sciences, http://dx.doi.org/10.1016/j.lfs.2015.12.044, 145, 224-232, 2016.01. |
| 26. | Mitsuru Tanaka, Eiji Tanaka, Noe Obinata, Toshiro Matsui, Visualization of Tocopherol Acetate Absorbed Inside Laminated Films by a Matrix-assisted Laser Desorption/Ionization-imaging Mass Spectrometry, Food Science and Technology Research, doi: 10.3136/fstr.21.821, 21, 6, 821-826, 2015.11. |
| 27. | Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Mitsuru Tanaka, Toshiro Matsui, Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats, Naunyn-Schmiedeberg's Archives of Pharmacology, 10.1007/s00210-015-1171-9, 288, 1113-1117, 2015.09. |
| 28. | Takashi Ichinose, Kazuki Moriyasu, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya, Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain, Bioscience, Biotechnology, and Biochemistry, DOI: 10.1080/09168451.2015.1044932, 79, 9, 1542-1547, 2015.03. |
| 29. | Ha-Young Park, Yuri Kunitake, Naoto Hirasaki, Mitsuru Tanaka, Toshiro Matsui, Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1080/09168451.2014.951027, 79, 1, 130-137, 2015.01. |
| 30. | Thanutchaporn Kumrungsee, Tomomi Saiki, Sayaka Akiyama, Kentaro Nakashima, Mitsuru Tanaka, Yutaro Kobayashi, Toshiro Matsui, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, Biochimica et Biophysica Acta, 10.1016/j.bbagen.2014.07.020, 1840, 3073-3078, 2014.10. |
| 31. | Jian Zhao, Aki Suyama, Mitsuru Tanaka, Toshiro Matsui, Ferulic Acid Enhances the Vasorelaxant Effect of Epigallocatechin Gallate in Tumor Necrosis Factor-Alpha-induced Inflammatory Rat Aorta, The Journal of Nutritional Biochemistry, 10.1016/j.jnutbio.2014.03.013, 25, 7, 807-814, 2014.07. |
| 32. | Thanutchaporn Kumrungsee, Zhengquan Wang, Shinya Matsumura, Tomomi Saiki, Mitsuru Tanaka, Toshiro Matsui, Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells., Food Chemistry, http://dx.doi.org/10.1016/j.foodchem.2013.11.143, 152, 218-224, 2014.06. |
| 33. | Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Takahisa Miyamoto, Mitsuru Tanaka, Toshiro Matsui, Attenuation of L-Type Ca2+ Channel Expression and Vasomotor Response in the Aorta with Age in Both Wistar-Kyoto and Spontaneously Hypertensive Rats, PLOS ONE, DOI: 10.1371/journal.pone.0088975, 9, 2, e88975, 1-9, 2014.02. |
| 34. | Eduardo M. N. NAKASHIMA, Hu-Qiang QING, Mitsuru Tanaka, Toshiro Matsui, Improved Detection of Di-peptides by Liquid Chromatography-Tandem Mass Spectrometry with 2,4,6-Trinitrobenzene Sulfonate Conversion, Bioscience, Biotechnology, and Biochemistry, http://dx.doi.org/10.1271/bbb.130448, 77, 10, 2094-2099, 2013.10. |
| 35. | Seong-Min Hong, Mitsuru Tanaka, Saori Yoshii, Toshiro Matsui, Enhanced Visualization of Small Peptides Absorbed in Rat Small Intestine by Phytic-Acid-Aided Matrix-Assisted Laser Desorption/ Ionization-Imaging Mass Spectrometry, Analytical Chemistry, 10.1021/ac402252j, 85, 10033-10039, 2013.09. |
| 36. | Chihiro Hashimoto, Yuri Iwaihara, Si Jing Chen, Tanaka Mitsuru, Toshiaki Watanabe, Toshiro Matsui, Highly-Sensitive Detection of Free Advanced Glycation End-Products by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry with 2,4,6-Trinitrobenzene Sulfonate Derivatization, Analytical Chemistry, 10.1021/ac400294q, 85, 4289-4295, 2013.04. |
| 37. | Mitsuru Tanaka, Jian Zhao, Aki Suyama, and Toshiro Matsui, Epigallocatechin Gallate Promotes the Vasorelaxation Power of the Antiatherosclerotic Dipeptide Trp-His in Contracted Rat Aorta, Journal of Agricultural and Food Chemistry, 10.1021/jf3010228, 60, 9048-9054, 2012, 60, 9048-9054, 2012.09, [URL]. |
| 38. | Yutaro Kobayashi, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui, The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca2+ channels in rat vascular smooth muscle cells, FEBS Open Bio, 10.1016/j.fob.2012.04.005, 2, 83-88, 2012.04. |
| 39. | S. Tokuda, T. Fukuda, Y. Kobayashi, M. Tanaka, T. Matsui, Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats., Biosci. Biotechnol. Biochem., 10.1271/bbb.110806, 76, 4, 828-830, 2012.04. |
| 40. | Eduardo M.N. Nakashima, Akihiro Kudo, Yuri Iwaihara, Mitsuru Tanaka, Kiyoshi Matsumoto, Toshiro Matsui, Application of 13C stable isotope labeling liquid chromatographymultiple reaction monitoringtandem mass spectrometry method for determining intact absorption of bioactive dipeptides in rats, Analytical Biochemistry, doi:10.1016/j.ab.2011.02.037, 414, 109-116, 2011.03. |
| 41. | Zhengquan Wang, Shimpei Watanabe, Yutaro Kobayashi, Mitsuru Tanaka, Toshiro Matsui, Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like l-type Ca2+ channels, Peptides, doi:10.1016/j.peptides.2010.07.013, 31, 11, 2060-2066, 2010.08. |
| 42. | T. Matsui, M. Sato, M. Tanaka, Y. Yamada, S. Watanabe, Y. Fujimoto, K. Imaizumi, K. Matsumoto, Vasodilating di-peptide Trp-His can prevent atherosclerosis in apolipoprotein E-deficient mice., Br. J. Nutr., 103, 309-313, 2010.02. |
| 43. | M. Tanaka, S. Watanabe, Z. Wang, T. Matsui, K. Matsumoto, His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx., Peptides , 30, 1502-1507, 2009.08. |
| 44. | Y. Ushida, T. Matsui, M. Tanaka, K. Matsumoto, H. Hosoyama, A. Mitomi, Y. Sagesaka, T. Kakuda, Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta., J. Nutr. Biochem., 19, 700-707, 2008.10. |
| 45. | M. Tanaka, M. Tokuyasu, T. Matsui, K. Matsumoto, Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of SpragueDawley rats., Life Sci., 82, 869-875, 2008.04. |
| 46. | M. Tanaka, T. Matsui, Y. Ushida, K. Matsumoto, Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats., Biosci. Biotechnol. Biochem., 70, 2292-2295, 2006.09. |
| 47. | T. Ueno, M. Tanaka, T. Matsui, K. Matsumoto, Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-switching technique., Anal. Sci. , 10.2116/analsci.21.997, 21, 8, 997-1000, 2005.08. |
| 48. | T. Matsui, T. Ueno, M. Tanaka, H. Oka, T. Miyamoto, K. Osajima, K. Matsumoto, Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells., Hypertens. Res., 10.1291/hypres.28.545, 28, 6, 545-552, 2005.06. |
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