|元村 祐貴（もとむら ゆうき）||データ更新日：2021.06.03|
助教 ／ 芸術工学研究院 デザイン人間科学部門 生理人類学講座
|1.||Yuki Motomura, Ruri Katsunuma, Naoko Ayabe, Kentaro Oba, Yuri Terasawa, Shingo Kitamura, Yoshiya Moriguchi, Akiko Hida, Yuichi Kamei, Kazuo Mishima, Decreased activity in the reward network of chronic insomnia patients, Scientific reports , 2021.02, In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli..|
|2.||Taisuke Eto, Petteri Teikari, Raymond P. Najjar, Yuki Nishimura, Yuki Motomura, Manami Kuze & Shigekazu Higuchi, A Purkinje image‑based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo, Scientific Reports, 2020.09.|
|3.||Yoshimura, Michitaka; Kitamura, Shingo; Eto, Norihito; Hida, Akiko; Katsunuma, Ruri; Ayabe, Naoko; Motomura, Yuki; Nishiwaki, Yuji; Negishi, Kazuno; Tsubota, Kazuo; Mishima, Kazuo, Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions, BIOLOGICAL RHYTHM RESEARCH, 10.1080/09291016.2020.1782691, 2020.06.|
|4.||Lee, Sang-Il; Kinoshita, Saki; Noguchi, Anna; Eto, Taisuke; Ohashi, Michihiro; Nishimura, Yuki; Maeda, Kaho; Motomura, Yuki; Awata, Yasuhiro; Higuchi, Shigekazu, Melatonin suppression during a simulated night shift in medium intensity light is increased by 10-minute breaks in dim light and decreased by 10-minute breaks in bright light, CHRONOBIOLOGY INTERNATIONAL, 10.1080/07420528.2020.1752704, 2020.04.|
|5.||Takashi Abe, Kazuo Mishima, Shingo Kitamura, Akiko Hida, Yuichi Inoue, Koh Mizuno, Kosuke Kaida, Kyoko Nakazaki, Yuki Motomura, Kazushi Maruo, Toshiko Ohta, Satoshi Furukawa, David F. Dinges, Katsuhiko Ogata, Tracking intermediate performance of vigilant attention using multiple eye metrics, Sleep, 10.1093/sleep/zsz219, 43, 3, 2020.03, [URL], Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open-the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300-500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named "eye-metrical estimation version of the PVT: PVT-E," can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate..|
|6.||Yuko Hakamata, Shotaro Komi, Eisuke Sato, Shuhei Izawa, Shinya Mizukami, Yoshiya Moriguchi, Yuki Motomura, Mie Matsui, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya, Cortisol-related hippocampal-extrastriate functional connectivity explains the adverse effect of cortisol on visuospatial retrieval, Psychoneuroendocrinology, 10.1016/j.psyneuen.2019.04.013, 109, 2019.11, [URL], Cortisol is known to affect visuospatial memory through its major binding site in the brain, the hippocampus. The synchronization of neural activity between the hippocampus, prefrontal cortex (PFC), and visual cortex is presumed to be essential for the formation of visuospatial memory because of their visuospatial learning-dependent neuroplasticity. However, it remains unclear how hippocampal connectivity with the PFC and visual cortex is involved in the relationship between cortisol and visuospatial memory in humans. We thus investigated whether functional connectivity (FC) of the hippocampus, specifically its rostral and caudal subdivisions, mediates the relationship between visuospatial memory and endogenous cortisol. One-hundred sixty-six healthy young adults underwent standard neuropsychological tests to assess visuospatial construction (a complex figure copying test) and retrieval (the corresponding recall test) and collected their saliva at 6-time points across 2 consecutive days for measurement of daily cortisol concentrations (dCOR). Ninety of them received resting-state fMRI scans. Greater dCOR was significantly associated with better figure copying performance, but contrastingly with poorer figure recall. In proportion to dCOR, the rostral hippocampus (rHC) showed significantly increased FC with the PFC (including its dorsolateral and medial parts) and the inferior lateral occipital cortex (iLOC), while the caudal hippocampus had increased FC with the anterior middle temporal cortex. Of the cortisol-related hippocampal connectivity, the rHC-iLOC FC was specifically correlated with figure recall and showed complete mediation for the negative relationship of dCOR with figure recall. These results suggest that cortisol might have enhancing effects on visuospatial encoding as well as impairing effects on visuospatial retrieval, possibly due to its occupancy patterns of corticosteroid receptors. Cortisol's adverse effects on visuospatial retrieval might be explained through cortisol-related rostral hippocampal connectivity with the iLOC, which is a part of the extrastriate cortex implicated in visuospatial perception. Thorough dissection of hippocampal-prefrontal-extrastriate connectivity might facilitate the understanding of neural mechanisms underlying cortisol's contrasting effects on encoding (or consolidation) and retrieval of visuospatial information..|
|7.||Sayuri Hayashi, Fumi Kishida, Shigekazu Higuchi, Yuki Motomura, Psychological Effect of the Menstrual Cycle on an Emotional Go/Nogo Task and Its Relation to Plasma Oxytocin and Prolactin Levels, Journal of physiological anthropology, 2019.06.|
|8.||Sayuri Hayashi, Ayami Tsuru, Fumi Kishida, Yeon Kyu Kim, Shigekazu Higuchi, Yuki Motomura, ERP study on the associations of peripheral oxytocin and prolactin with inhibitory processes involving emotional distraction, Journal of physiological anthropology, 10.1186/s40101-019-0196-z, 38, 1, 2019.05, [URL], Background: Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children's facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving. Methods: Participants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured. Results: The results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors. Conclusions: Our findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions..|
|9.||西村英伍、元村祐貴、勝沼るり、吉村道孝、三島和夫、尾方義人, 機械学習を用いた動画解析による生体情報の自動追跡技術：瞼裂幅計測に用いた一例, 日本生理人類学会誌, 2019.02.|
|10.||元村 祐貴, 脳と適応・順応：生理人類学における脳研究のこれまでとこれから, 日本生理人類学会誌, 2019.01.|
|11.||Hakamata, Yuko; Mizukami, Shinya; Komi, Shotaro; Sato, Eisuke; Moriguchi, Yoshiya; Motomura, Yuki; Maruo, Kazushi; Izawa, Shuhei; Kim, Yoshiharu; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni, Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial, JOURNAL OF AFFECTIVE DISORDERS, 10.1016/j.jad.2018.06.018, 238, 472-481, 2018.10.|
|12.||Sayuri Hayashi, Hiroko Wada, Sung-Phil Kim, Yuki Motomura, Shigekazu Higuchi, Yeon-Kyu Kim, Enhanced Nogo-P3 amplitudes of mothers compared with non-mother women during an emotional Go/Nogo task: Journal of Physiological Anthropology, 2018.04.|
|13.||Motomura Y, Katsunuma R, yoshimura M, Mishima K, Two Days’ Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity, SLEEP, 2017.10,
Sleep debt (SD) has been suggested to evoke emotional instability by diminishing the suppression of the amygdala by the medial prefrontal cortex (MPFC). Here, we investigated how short-term SD affects resting-state functional connectivity between the amygdala and MPFC, self-reported mood, and sleep parameters.
Eighteen healthy adult men aged 29 ± 8.24 years participated in a 2-day sleep control session (SC; time in bed [TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each session, resting-state functional magnetic resonance imaging was performed, followed immediately by measuring self-reported mood on the State-Trait Anxiety Inventory-State subscale (STAI-S).
STAI-S score was significantly increased, and functional connectivity between the amygdala and MPFC was significantly decreased in SD compared with SC. Significant correlations were observed between reduced rapid eye movement (REM) sleep and reduced left amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced FCL_amg-MPFC and increased STAI-S score in SD compared with SC.
These findings suggest that reduced MPFC functional connectivity of amygdala activity is involved in mood deterioration under SD, and that REM sleep reduction is involved in functional changes in the corresponding brain regions. Having adequate REM sleep may be important for mental health maintenance..
|14.||Katsunuma R, Oba K, Kitamura S, Motomura Y, Terasawa Y, Nakazaki K, Hida A, Moriguchi Y, Mishima K., Unrecognized sleep loss accumulated in daily life can promote brain hyperreactivity to food cue. SLEEP, 2017.10.|
|15.||Hakamata Y, Komi S, Moriguchi Y, Izawa S, Motomura Y, Sato E, Mizukami S, Kim Y, Hanakawa T, Inoue Y, Tagaya H, Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety.Sci Rep, 2017.08.|
|16.||Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K., Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.Front Neurol.8:306. 2017, 2017.07.|
|17.||Hida A, Ohsawa Y, Kitamura S, Nakazaki K, Ayabe N, Motomura Y, Matsui K, Kobayashi M, Usui A, Inoue Y, Kusanagi H, Kamei Y, Mishima K, Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders. Transl Psychiatry, 7 (4): e1106, 2017., 2017.04.|
|18.||Shingo Kitamura, Yasuko Katayose, Kyoko Nakazaki, Yuki Motomura, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Minori Enomoto, Yoshiya Moriguchi, Akiko Hida, Kazuo Mishima, Estimating individual optimal sleep duration and potential sleep debt, SCIENTIFIC REPORTS, 2016.10.|
|19.||Hiroki Murakami, Ruri Katsunuma, Kentaro Oba, Yuri Terasawa, Yuki Motomura, Kazuo Mishima, Yoshiya Moriguchi, Neural Networks for Mindfulness and Emotion Suppression, PLOS ONE, 10.1371/journal.pone.0128005, 10, 6, 2015.06.|
|20.||Yuki Motomura, Akira Takeshita, Yuka Egashira, Takayuki Nishimura, Yeon-kyu Kim, Shigeki Watanuki , Interaction between valence of empathy and familiarity: is it difficult to empathize with the positive events of a stranger?, Journal of Physiological Anthropology, 2015.03.|
|21.||Yuki Motomura, Akira Takeshita, Yuka Egashira, Takayuki Nishimura, Yeon-Kyu Kim, Shigeki Watanuki , Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study, JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 10.1186/s40101-015-0053-7, 34, 2015.03.|
|22.||Kyoko Nakazaki, Shingo Kitamura, Yuki Motomura, Akiko Hida, Yuichi Kamei, Naoki Miura, Kazuo Mishima, Validity of an algorithm for determining sleep/wake states using a new actigraph, JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 10.1186/1880-6805-33-31, 33, 2014.10.|
|23.||Yuki Motomura, Shingo Kitamura, Kentaro Oba, Yuri Terasawa, Minori Enomoto, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Sleepiness induced by sleep-debt enhanced amygdala activity for subliminal signals of fear, BMC NEUROSCIENCE, 10.1186/1471-2202-15-97, 15, 2014.08.|
|24.||Akiko Hida, Shingo Kitamura, Yosuke Ohsawa, Minori Enomoto, Yasuko Katayose, Yuki Motomura, Yoshiya Moriguchi, Kentaro Nozaki, Makiko Watanabe, Sayaka Aritake, Shigekazu Higuchi, Mie Kato, Yuichi Kamei, Shin Yamazaki, Yu-Ichi Goto, Masaaki Ikeda, Kazuo Mishima, In vitro circadian period is associated with circadian/sleep preference., Scientific reports, 2013.03.|
|25.||Yuki Motomura, Shingo Kitamura, Kentaro Oba, Yuri Terasawa, Minori Enomoto, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Sleep Debt Elicits Negative Emotional Reaction through Diminished Amygdala-Anterior Cingulate Functional Connectivity, PLOS ONE, 10.1371/journal.pone.0056578, 8, 2, 2013.02.|
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