| 1. |
Koichiro Hayashi, Kunio Ishikawa, Effects of Nanopores on the Mechanical Strength, Osteoclastogenesis, and Osteogenesis in Honeycomb Scaffolds（selected as a Journal of Materials Chemistry B HOT Paper）, Journal of Materials Chemistry B, 10.1039/D0TB01498B, 2020.08, The scaffold chemical composition and pore architecture are critical for successful bone regeneration. Although the effects of chemical composition, micron-scale pores, and macropores (Z100 mm) are known, those of nanometer-scale pores (nanopores) are unknown. Here, honeycomb scaffolds (HCSs) composed of carbonate apatite and bone mineral, were fabricated with three distinct nanopore volumes, while other parameters were comparable between HCSs. Their compressive strengths and nanopore volumes linearly correlated. The HCSs were implanted into critical-sized bone defects (CSDs) in the rabbit femur distal epiphyses. The nanopore volume affected both osteoclastogenesis and osteogenesis. HCSs with nanopore volumes of Z0.15 cm3 g-1 promoted osteoclastogenesis, contributing to bone maturation and bone formation within 4 weeks. However, HCSs with nanopore volumes of 0.07 cm3 g-1 promoted significantly less bone maturation and neoformation. Nevertheless, HCSs with nanopore volumes of Z0.18 cm3 g-1 did not undergo continuous bone regeneration throughout the 12 week period due to excessive osteoclastogenesis, which favored HCS resorption over bone neoformation. When the nanopore volume was 0.15 cm3 g-1, osteoclastogenesis and osteogenesis progressed harmonically, resulting in HCS replacement with new bone. Our results demonstrate that the nanopore volume is critical for controlling osteoclastogenesis and osteogenesis. These insights may help establish a coherent strategy for developing scaffolds for different applications.. |
| 2. |
Michihiro Nakamura, Koichiro Hayashi, Junna Nakamura, Chihiro Mochizuki, Takuya Murakami, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Near-Infrared Fluorescent Thiol-Organosilica Nanoparticles That Are Functionalized with IR-820 and Their Applications for Long-Term Imaging of in Situ Labeled Cells and Depth-Dependent Tumor in Vivo Imaging , Chemistry of Materials, 10.1021/acs.chemmater.0c01414, 2020.08, Thiol-organosilica nanoparticles that are internally functionalized with IR-820 (thiol-OS/IR820) were prepared via a one-pot process for near-infrared (NIR) fluorescence in vivo imaging. Thiol-OS/IR820 demonstrated broad-band emissive NIR fluorescence with multiple new fluorescent peaks that differed from those of the IR-820 molecule and upconversion fluorescence originated from thiol-OS. Thiol-OS/IR820 was biocompatible and did not show significant toxicity in vitro and in vivo. We conducted in vivo tracking of in situ labeled cells against subcutaneous xenograft cells. The in vivo imaging showed a migration and an accumulation of the in situ labeled cells to the site of xenograft cells. Then, a reduction of the grafted cells was observed after 3 weeks. Next, we conducted in vivo tumor imaging of a mouse with a subcutaneous xenograft tumor using intravenous administration of thiol-OS/IR820. Using three wavelengths of light emission, depth-dependent NIR fluorescence imaging of a mouse with a subcutaneous xenograft tumor was conducted. The accumulation of particles in the tumor tissue due to the enhanced permeability and retention (EPR) effect was observed depth-dependently. NIR fluorescence in vivo imaging using thiol-OS/IR820 is useful for long-term observation and shows substantial promise for the visualization of novel biological phenomena in vivo.. |
| 3. |
Koichiro Hayashi, Atsuto Tokuda, Jin Nakamura, Ayae Sugawara-Narutaki, Chikara Ohtsuki, Tearable and fillable composite sponges capable of heat generation and drug release in response to alternating magnetic field, Materials, 10.1039/10.3390/ma13163637, 2020.08. |
| 4. |
Rui Shi,Koichiro Hayashi,Kunio Ishikawa, Rapid Osseointegration Bestowed by Carbonate Apatite Coating of Rough Titanium, Advanced Materials Interfaces, 10.1002/admi.202000636, 2020.07, Titanium (Ti) implants that realize rapid osseointegration are required for favorable outcomes. Rough implant surfaces favor osseointegration, hence, coating implants with natural bone mineral, i.e., carbonate apatite (CO3Ap), may be effective for osseointegration. To achieve rapid osseointegration, rough-Ti substrates are coated with CO3Ap (CO3Ap-Ti) and the effects are evaluated in vitro and in vivo. For comparison, rough-Ti without coating (rough-Ti) and calcite-coated rough-Ti (calcite-Ti) substrates are fabricated. The adhesive strengths of calcite and CO3Ap to the substrates are ≈56.6 and ≈76.8 MPa, respectively, being significantly higher than the strength defined in ISO13779-2 (15 MPa). Calcite and CO3Ap coatings significantly promote preosteoblastic MC3T3-E1 cell proliferation. Additionally, the CO3Ap coating promotes higher osteogenic differentiation activity than the calcite coating. Implantation of CO3Ap-Ti into rabbit tibia defects prompts bone maturation, compared to calcite-Ti or rough-Ti implantation. The bone-implant contact percentage with CO3Ap-Ti and calcite-Ti is higher than that with rough-Ti. Consequently, CO3Ap-Ti acquires a robust bond with the host bone at an early stage (4 weeks postimplantation), compared to calcite-Ti or rough-Ti: the CO3Ap-Ti–bone bonding strength is ≈1.9- and ≈5.5-fold higher than that of calcite-Ti and rough-Ti, respectively. Thus, CO3Ap coating of Ti implants effectively achieve rapid osseointegration.. |
| 5. |
Koichiro Hayashi, Melvin L. Munar, Kunio Ishikawa, Effects of macropore size in carbonate apatite honeycomb scaffolds on bone regeneration, Materials Science and Engineering: C, https://doi.org/10.1016/j.msec.2020.110848, 111, 110848, 2020.06, The pore architecture of scaffolds is a critical factor for angiogenesis and bone regeneration. Although the effects of scaffold macropore size have been investigated, most scaffolds feature macropores with poor uniformity and interconnectivity, and other parameters (e.g., microporosity, chemical composition, and strut thickness) differ among scaffolds. To clarify the threshold of effective macropore size, we fabricated honeycomb scaffolds (HCSs) with distinct macropore (i.e., channel) sizes (~100, ~200, and ~300 μm). The HCSs were composed of AB-type carbonate apatite with ~8.5% carbonate ions, i.e., the same composition as human bone mineral. Their honeycomb architecture displayed uniformly sized and orderly arranged channels with extremely high interconnectivity, and all the HCSs displayed ~100-μm-thick struts and 0.06 cm3 g−1 of micropore volume. The compressive strengths of
HCSs with ~100-, ~200-, and ~300-μm channels were higher than those of reported scaffolds, and decreased with increasing channel size: 62 ± 6, 55 ± 9, and 43 ± 8 MPa, respectively. At four weeks after implantation in rabbit femur bone defects, new bone and blood vessels were formed in all the channels of these HCSs. Notably, the ~300-μm channels were extensively occupied by new bone. We demonstrated that high interconnectivity and uniformity of channels can decrease the threshold of effective macropore size, enabling the scaffolds to maintain high mechanical properties and osteogenic ability and serve as implants for weight-bearing areas.. |
| 6. |
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Granular Honeycombs Composed of Carbonate Apatite, Hydroxyapatite, and β-Tricalcium Phosphate as Bone Graft Substitutes: Effects of Composition on Bone Formation and Maturation, ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.0c00060, 3, 3, 1787-1795, 2020.03. |
| 7. |
Tansza Setiana Putri, Koichiro Hayashi, Kunio Ishikawa, Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules, Journal of Biomedical Materials Research Part A, 108, 625-632, 2020.01. |
| 8. |
Rui Shi, Koichiro Hayashi, LT Bang, Kunio Ishikawa, Effects of surface roughening and calcite coating of titanium on cell growth and differentiation, Journal of Biomaterials Applications, 34, 917-927, 2020.02. |
| 9. |
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Carbonate Apatite Micro-Honeycombed Blocks Generate Bone Marrow-Like Tissues as well as Bone, Advanced Biosystems, 2019.09. |
| 10. |
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration: effects of composition on biological responses, Materials Today Bio, 4, 100031, 2019.09, Synthetic scaffolds exhibiting bone repair ability equal to that of autogenous bone are required in the fields of orthopedics and dentistry. A suitable synthetic bone graft substitute should induce osteogenic differentiation of mesenchymal stem cells, osteogenesis, and angiogenesis. In this study, three types of honeycomb blocks (HCBs), composed of hydroxyapatite (HAp), β-tricalcium phosphate (TCP), and carbonate apatite (CO3Ap), were fabricated, and the effects of HCB composition on bone formation and maturation were investigated. The HC structure was selected to promote cell penetration and tissue ingrowth. HAp and β-TCP HCBs were fabricated by extrusion molding followed by sintering. The CO3Ap HCBs were fabricated by extrusion molding followed by sintering and dissolution-precipitation reactions. These HCBs had similar macroporous structures: all harbored uniformly distributed macropores (∼160 μm) that were regularly arrayed and penetrated the blocks unidirectionally. Moreover, the volumes of macropores were nearly equal (∼0.15 cm3/g). The compressive strengths of CO3Ap, HAp, and β-TCP HCBs were 22.8 ± 3.5, 34.2 ± 3.3, and 24.4 ± 2.4 MPa, respectively. Owing to the honeycomb-type macroporous structure, the compressive strengths of these HCBs were higher than those of commercial scaffolds with intricate three-dimensional or unidirectional macroporous structure. Notably, bone maturation was markedly faster in CO3Ap HCB grafting than in β-TCP and HAp HCB grafting, and the mature bone area percentages for CO3Ap HCBs at postsurgery weeks 4 and 12 were 14.3- and 4.3-fold higher and 7.5- and 1.4-fold higher than those for HAp and β-TCP HCBs, respectively. The differences in bone maturation and formation were probably caused by the disparity in concentrations of calcium ions surrounding the HCBs, which were dictated by the inherent material resorption behavior and mechanism; generally, CO3Ap is resorbed only by osteoclastic resorption, HAp is not resorbed, and β-TCP is rapidly dissolved even in the absence of osteoclasts. Besides the composition, the microporous structure of HC struts, inevitably generated during the formation of HCBs of various compositions, may contribute to the differences in bone maturation and formation.. |
| 11. |
Koichiro Hayashi, Melvin L. Munar, Kunio Ishikawa, Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration, Ceramics International, 45, 15429-15434, 2019.05. |
| 12. |
Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima, Kunio Ishikawa, Fabrication and Histological Evaluation of Porous Carbonate Apatite Block from Gypsum Block Containing Spherical Phenol Resin as a Porogen, Materials, https://doi.org/10.3390/ma12233997, 12, 3997, 2019.12. |
| 13. |
Kunio Ishikawa, Tya Arifta, Koichiro Hayashi, Kanji Tsuru, Fabrication and Evaluation of Interconnected Porous Carbonate Apatite from Alpha Tricalcium Phosphate Spheres, Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 107, 2, 269-277, 2019.02. |
| 14. |
Koichiro Hayashi, Takuma Maruhashi, Wataru Sakamoto, Toshinobu Yogo, Organic-inorganic Hybrid Hollow Nanoparticles Suppress Oxidative Stress and Repair Damaged Tissues for Treatment of Hepatic Fibrosis, Advanced Functional Materials, 28, 1706332, 2018.03, Current therapeutic options for the treatment of liver fibrosis are limited, and transplantation is often the only effective option for end-stage fibrotic diseases. To overcome this problem, a nanoparticle-based treatment as an alternative to transplantation is developed. Multifunctional organic–inorganic hybrid hollow nanoparticles (HNPs) containing silibinin are synthesized by mixing precursors in ammonia water at 60 °C for 1 min. The HNPs are mainly composed of siloxanes and disulfides and have surface thiols. The disulfides are cleaved by intracellular glutathione and reduced to thiols, leading to the deformation of the HNPs. Silibinin molecules are released through the cracks formed by HNP deformation. Furthermore, the HNPs suppress the generation of hydroxyl radicals, a major cause of liver fibrosis, via sulfenylation reactions of HNP thiols. Retinol-modified HNPs target Kupffer cells and hepatic stellate cells, which are essential for hepatic fibrogenesis. The combined suppression of hydroxyl radical generation and release of silibinin using the HNPs decreases the proportion of fibrotic tissues and improves hepatic function. The therapeutic efficacy is greater than can be achieved by the suppression of hydroxyl radical generation alone and the injection of silibinin alone. Thus, HNPs are promising for the treatment of liver fibrosis.. |
| 15. |
Koichiro Hayashi, Shota Yamada, Hikaru Hayashi, Wataru Sakamoto, Toshinobu Yogo, Red Blood Cell-like Particles with the Ability to Avoid Lung and Spleen Accumulation for the Treatment of Liver Fibrosis, Biomaterials, 156, 45-55, 2018.02. |
| 16. |
Koichiro Hayashi, Hikaru Hayashi, Shota Yamada, Wataru Sakamoto, Toshinobu Yogo, Cellulose-Based Molecularly Imprinted Red-Blood-Cell-Like Microparticles for the Selective Capture of Cortisol, Carbohydrate Polymers, 193, 173-178, 2018.04, Magnetite-nanoparticle-containing red-blood-cell-like-microparticles (M-RBC-MPs) with a selective ability for trapping cortisol (COR) were synthesized by an electrospray technique of a molecularly imprinted ethyl(hydroxyethyl) cellulose (EHEC)-based precursor. The as-synthezied M-RBC-MPs were ∼3-μm-disks with a dent. MRBC-MPs contained magnetite nanoparticles below 15 nm in diameter, which exhibited magnetization and no room-temperature coercivity. The molecularly imprinted M-RBC-MPs (MI-M-RBC-MPs) passed through pores less than their diameter. The MI-M-RBC-MPs selectively trapped COR from a solution containing molecules similar to COR, whereas non-imprinted M-RBC-MPs did not trap COR. Furthermore, magnets were used to capture the water-dispersed MI-M-RBC-MPs flowing in a tube. Based on the above results, MI-M-RBC-MPs may selectively trap COR while simultaneously circulating in the blood, followed by their removal from the blood using magnets.. |
| 17. |
Koichiro Hayashi, Atsuto Tokuda, and Wataru Sakamoto, Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles (invited), International Journal of Molecular Sciences, 2018.08. |
| 18. |
Naoya Ozawa, Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, Synthesis of titania nanoparticle-dispersed hybrid membranes fromallyloxytitanium and phosphonic acid derivatives for fuel cell, Journal of Membrane Science, 563, 221-228, 2018.10. |
| 19. |
Kunio Ishikawa, Youji Miyamoto, Akira Tsuchiya, Koichiro Hayashi, Kanji Tsuru and Go Ohe, Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and β-Tricalcium Phosphate Bone Substitutes, Materials, 11, 1993, 2018.10. |
| 20. |
Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kiyoe Kurahashi, Sumiko Yoshida, Kumiko Kagawa, Itsuro Endo, Kenichi Aihara, Mariko Ikuo, Kohji Itoh, Koichiro Hayashi, Michihiro Nakamura and Masahiro Abe, Effective impairment of myeloma cells and their progenitors by hyperthermia, Oncotarget, 9, 10307-10316, 2018.02. |
| 21. |
Kouta Noritake, Wataru Sakamoto, Isamu Yuitoo, Teruaki Takeuchi, Koichiro Hayashi, Toshinobu Yogo, Fabrication of Lead-Free Piezoelectric Li2CO3-Added (Ba,Ca)(Ti,Sn)O3 Ceramics under Controlled Low Oxygen Partial Pressure and Their Properties, Japanese Journal of Applied Physics, 57, 021501-1‒021501-7, 2018.02. |
| 22. |
Masaya Takemoto, Masatomo Hattori, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo, Metallic Glass Separators for Fuel Cells at Intermediate Temperatures, Materials Letters, 206, 87–90, 2017.11. |
| 23. |
Wataru Sakamoto, Kouta Noritake, Hiroki Ichikawa, Koichiro Hayashi, Toshinobu Yogo, Fabrication and Properties of Nonreducible Lead-Free Piezoelectric Mn-Doped (Ba,Ca)TiO3 Ceramics, Ceramics International, 43, S166‒S171, 2017.08. |
| 24. |
Masaya Takemoto, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo, Synthesis of Inorganic-organic Hybrid Membranes Consisting of Organotrisiloxane Linkages and Their Fuel Cell Properties at Intermediate Temperatures, Polymer, 120, 264–271, 2017.06. |
| 25. |
Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Masafumi Harada, Keisuke Izumi, Yoshihiro Tsuruo, and Toshinobu Yogo, Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles, Scientific Reports, 7, 3953, 2017.06. |
| 26. |
Koichiro Hayashi, Yusuke Sato, Hiroki Maruoka, Wataru Sakamoto, and Toshinobu Yogo, Organic-Inorganic Hybrid Nanoparticles for Tracking the Same Cells Seamlessly at the Cellular, Tissue, and Whole Body Levels, ACS Biomaterials Science & Engineering, 3, 1129–1135, 2017.06. |
| 27. |
Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Takafumi Kanadani, Masafumi Harada, Toshinobu Yogo, Relaxometric Property of Organosilica Nanoparticles Internally Functionalized with Iron Oxide and Fluorescent Dye for Multimodal Imaging, Journal of Colloid and Interface Science, 49, 127–135, 2017.04. |
| 28. |
Koichiro Hayashi, Yoshitaka Sato, Wataru Sakamoto, Toshinobu Yogo, Theranostic Nanoparticles for MRI-Guided Thermochemotherapy: Tight Clustering of Magnetic Nanoparticles Boosts Relaxivity and Heat-Generation Power, ACS Biomaterials Science & Engineering, 3, 95–105, 2017.01. |
| 29. |
Koichiro Hayashi, Takuma Maruhashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-guided Trimodal Therapy, Advanced Functional Materials, 26, 8613–8622, 2016.12. |
| 30. |
Naoya Ozawa, Koichiro Hayashi, Shin-ichi Yamaura, Wei Zhang, Wataru Sakamoto, Toshinobu Yogo, Synthesis of Inorganic-Organic Hybrid Membranes Consisting of Triazole Linkages Formed by the Azide-Alkyne Click Reaction, Journal of Membrane Science, 517, 21–29, 2016.11. |
| 31. |
Rika Maruyama, Wataru Sakamoto, Isamu Yuitoo, Teruaki Takeuchi, Koichiro Hayashi, Toshinobu Yogo, Photocurrent Enhancement of Chemically Synthesized Ag Nanoparticle-Embedded BiFeO3 Thin Films, Japanese Journal of Applied Physics, 55, 10TA14-1, 2016.10. |
| 32. |
Koji Takahashi, Junji Umeda, Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, One-Pot Synthesis of Inorganic/Organic Hybrid Membranes from Organoalkoxysilane, Hydroimidazole Derivative, and Cyclic Sulfonic Acid Ester, Journal of Materials Science, 51, 3398–3407, 2016.04. |
| 33. |
Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI-Guided Local Magnetic Thermochemotherapy, Advanced Functional Materials, 26, 1708–1718, 2016.03. |
| 34. |
Tatsuo Hoshino, Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, One-Pot Synthesis of Proton-Conductive Inorganic–Organic Hybrid Membranes from Organoalkoxysilane and Phosphonic Acid Derivatives, Journal of Membrane Science, 502, 133–140, 2016.03. |
| 35. |
Sergey Zhukov, Yuri A. Genenko, Jurij Koruza, Jan Schultheiß, Heinz von Seggern, Wataru Sakamoto, Hiroki Ichikawa, Tatsuro Murata, Koichiro Hayashi, Toshinobu Yogo, Effect of Texturing on Polarization Switching Dynamics in Ferroelectric Ceramics, Applied Physics Letters, 108, 012907, 2016.01. |
| 36. |
Takeshi Katayama, Wataru Sakamoto, Isamu Yuitoo, Teruaki Takeuchi, Koichiro Hayashi, Toshinobu Yogo, Enhancement of Photoinduced Electrical Properties of Al-Doped ZnO/BiFeO3 Layered Thin Films Prepared by Chemical Solution Deposition, Japanese Journal of Applied Physics, 54, 10NA05, 2015.09. |
| 37. |
Michihiro Nakamura, Koichiro Hayashi, Mutsuki Nakano, Takafumi Kanadani, Kazue Miyamoto, Toshinari Kori, Kazuki Horikawa, Identification of Polyethylene Glycol-Resistant Macrophages on Stealth Imaging in Vitro Using Fluorescent Organosilica Nanoparticles, ACS Nano, 9, 1058–1071, 2015.02. |
| 38. |
Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, Iodinated Silica/Porphyrin Hybrid Nanoparticles for X-Ray Computedtomography/Fluorescence Dual-Modal Imaging of Tumors, Journal of Asian Ceramic Societies, 2, 429–434, 2014.12. |
| 39. |
Kiyofumi Katagiri, Keiko Ohta, Kaori Sako, Kei Inumaru, Koichiro Hayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Development and Potential Theranostic Applications of a Self-Assembled Hybrid of Magnetic Nanoparticle Clusters with Polysaccharide Nanogels, ChemPlusChem, 79, 1631–1637, 2014.11. |
| 40. |
Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Wataru Sakamoto, Toshinobu Yogo, Kazunori Ishimura, Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release, Theranostics, 4, 834–844, 2014.06. |
| 41. |
Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Kazunori Ishimura, Photostable Iodinated Silica/Porphyrin Hybrid Nanoparticles with Heavy-Atom Effect for Wide-Field Photodynamic/Photothermal Therapy Using Single Light Source, Advanced Functional Materials, 24, 503–513, 2014.01. |
| 42. |
Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, One-Pot Synthesis of Magnetic Nanoparticles Assembled on Polysiloxane Rod and Their Response to Magnetic Field, Colloid and Polymer Science, 291, 2837–2842, 2013.12. |
| 43. |
Koichiro Hayashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Kazunori Ishimura, Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment, Theranostics, 3, 366–376, 2013.04. |
| 44. |
Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Kazunori Ishimura, Gold Nanoparticle Cluster/Plasmon-Enhanced Fluorescent Silica Core-Shell Nanoparticles for X-Ray Computed Tomography/Fluorescence Dual-Mode Imaging of Tumors, Chemical Communications, 49, 5334–5336, 2013.04. |
| 45. |
Koichiro Hayashi, Michihiro Nakamura, Kazunori Ishimura, Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System, Advanced Healthcare Materials, 2, 756–763, 2013.03. |
| 46. |
Michihiro Nakamura, Kazunori Miyamoto, Koichiro Hayashi, Aziz Awaad, Masahito Ochiai, Kazunori Ishimura, Time-Lapse Fluorescence Imaging and Quantitative Single Cell and Endosomal Analysis of Peritoneal Macrophages Using Fluorescent Organosilica Nanoparticles, Nanomedicine: Nanotechnology, Biology, and Medicine, 9, 274–283, 2013.02. |
| 47. |
Koichiro Hayashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, Kazunori Ishimura, Synthesis and 3D Hierarchical Organization of 2D Structured Iron Oxide Based on Enzymatic Structure, Activity and Thermostability, Materials Research Bulletin, 47, 3959–3964, 2012.12. |
| 48. |
Michihiro Nakamura, Aziz Awaad, Koichiro Hayashi, Kazuhiko Ochiai, Kazunori Ishimura, Thiol-Organosilica Particles Internally Functionalized with Propidium Iodide as a Multicolor Fluorescence and X-ray Computed Tomography Probe and Application for Non-Invasive Functional Gastrointestinal Tract Imaging, Chemistry of Materials, 24, 3772–3779, 2012.10. |
| 49. |
Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Kazunori Ishimura, Near-Infrared Fluorescent Silica/Porphyrin Hybrid Nanorings for In Vivo Cancer Imaging, Advanced Functional Materials, 22, 3539–3546, 2012.09. |
| 50. |
Koichiro Hayashi, Kazuki Maeda, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo, In Situ Synthesis of Cobalt Ferrite Nanoparticle/Polymer Hybrid from a Mixed Fe-Co Methacrylate for Magnetic Hyperthermia, Journal of Magnetism and Magnetic Materials, 324, 3158–3164, 2012.09. |
| 51. |
Koichiro Hayashi, Michihiro Nakamura, Kazunori Ishimura, Silica-Porphyrin Hybrid Nanotubes for In Vivo Cell Tracking by Near-Infrared Fluorescence Imaging, Chemical Communications, 48, 3830–3832, 2012.02. |
| 52. |
Koichiro Hayashi, Michihiro Nakamura, Yoji Makita, Rise Fujiwara, Toshinari Kori, Kazunori Ishimura, Synthesis and Photocatalytic Activity of Sea Urchin-Shaped Rutile TiO2 Nanocrystals, Materials Letters, 65, 3037–3040, 2011.10. |
| 53. |
Koichiro Hayashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, Toshinari Kori, Kazunori Ishimura, Formation of TiO2 Nanostructures by Enzyme-Mediated Self-Assembly for the Destruction of Macrophages, Chemistry of Materials, 23, 3341–3347, 2011.07. |
| 54. |
Koichiro Hayashi, Michihiro Nakamura, Kazunori Ishimura, In Situ Synthesis and Photoresponsive Rupture of Organosilica Nanocapsules, Chemical Communications, 47, 1518–1520, 2010.11. |
| 55. |
Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo, Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual-Modality for Magnetic Resonance and Fluorescence Imaging, Small, 6, 2384–2391, 2010.11. |
| 56. |
Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo, High-Frequency, Magnetic Field-Responsive Drug Release from Magnetic Nanoparticle/Organic Hybrid Based on Hyperthermic Effect, ACS Applied Materials & Interfaces, 2, 1903–1911, 2010.07. |
| 57. |
Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo, One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol-Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging, Chemistry of Materials, 22, 3768–3772, 2010.06. |
| 58. |
Koichiro Hayashi, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo, Chemoselective Synthesis of Folic Acid-Functionalized Magnetite Nanoparticles via Click Chemistry for Magnetic Hyperthermia, Chemistry of Materials, 21, 1318–1325, 2009.04. |
| 59. |
Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, Magnetic and Rheological Properties of Monodisperse Fe3O4 Nanoparticle/Organic Hybrid, Journal of Magnetism and Magnetic Materials, 321, 450–457, 2009.03. |
| 60. |
Koichiro Hayashi, Toshifumi Shimizu, Hidefumi Asano, Wataru Sakamoto, Toshinobu Yogo, Synthesis of Spinel Iron Oxide Nanoparticle/Organic Hybrid for Hyperthermia, Journal of Materials Research, 23, 3415–3424, 2008.12. |
| 61. |
Koichiro Hayashi, Rintaro Fujikawa, Wataru Sakamoto, Mitsuteru Inoue, Toshinobu Yogo, Synthesis of Highly Transparent Lithium Ferrite Nanoparticle/Polymer Hybrid Self-standing Films Exhibiting Faraday Rotation in the Visible Region, Journal of Physical Chemistry C, 112, 14255–14261, 2008.09. |
| 62. |
Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo, In Situ Synthesis of Lithium Ferrite Nanoparticle/Polymer Hybrid, Journal of Materials Research, 22, 974–981, 2007.04. |
