九州大学 研究者情報
研究者情報 (研究者の方へ)入力に際してお困りですか?
基本情報 研究活動 教育活動
長尾 匡憲(ながお まさのり) データ更新日:2024.04.01



主な研究テーマ
ポルフィリンによるCO2光還元反応の制御を目指した高分子反応場の設計
キーワード:二酸化炭素、ポルフィリン、光反応、高分子ゲル
2022.04~2025.03.
フォールディングする糖鎖高分子と標的タンパク質との相互作用評価
キーワード:糖鎖高分子、フォールディング、分子間相互作用、糖鎖
2022.04~2024.03.
不凍タンパク質の模倣を目指した糖鎖高分子のライブラリー合成と評価
キーワード:不凍タンパク質 糖鎖高分子 光重合
2022.04~2025.03.
固定化光触媒と流通反応器を組み合わせたリビングラジカル重合系の開発
キーワード:流通反応、光触媒、リビング重合
2021.04~2024.03.
環状糖鎖高分子の構造設計による標的タンパク質への相互作用制御
キーワード:糖鎖 環状高分子 生体分子間相互作用
2021.04~2024.03.
研究業績
主要原著論文
1. 金文康、長尾匡憲、公文悠介、松本光、星野友、三浦佳子, Effects of Cyclic Glycopolymers Molecular Mobility on their Interactions with Lectins, ChemPlusChem, 2024.03.
2. 長尾匡憲, 堀江彩, 松本光, 星野友, 三浦佳子, Continuous-Flow PET-RAFT Polymerization in a Packed-Bed Reactor with Porphyrin-Immobilized Silica Particles, Industrial & Engineering Chemistry Research, 10.1021/acs.iecr.3c03496, 63, 1, 200-209, 2023.12.
3. 長尾匡憲,増田造,高井まどか,三浦佳子, Preparation of cellular membrane-mimicking glycopolymer interfaces by a solvent-assisted method on QCM-D sensor chips and their molecular recognition, Journal of Materials Chemistry B, 10.1039/D3TB02663A, 12, 1782-1787, 2024.01.
4. 長尾匡憲, 三浦佳子, Correlation between Self-Folding Behavior of Amphiphilic Polymers and Their Molecular Flexibility, ACS Macro Letters, 10.1021/acsmacrolett.3c00182, 2023, 12, 6, 733–737, 2023.05.
5. 長尾 匡憲、星野 友、三浦 佳子, Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins, Polymer Chemistry, 10.1039/D2PY00941B, 2022, 13, 5453-5457., 2022.09.
6. 長尾匡憲、山口愛、松原輝彦、星野友、佐藤智典、三浦佳子, De Novo Design of Star-Shaped Glycoligands with Synthetic Polymer Structures toward an Influenza Hemagglutinin Inhibitor, Biomacromolecules, 10.1021/acs.biomac.1c01483, 2021.12.
7. 長尾匡憲、植村剛、堀内輔、星野友、三浦佳子, Screening of a glycopolymer library for GM1 mimetics synthesized by the “carbohydrate module method”, Chemical Communications, doi.org/10.1039/D1CC04394C, 2021.09.
8. 長尾匡憲、吉瀬誠也、星野友、三浦佳子, Influence of Monomer Structures for Polymeric Multivalent Ligands: Consideration of the Molecular Mobility of Glycopolymers, Biomacromolecules, doi.org/10.1021/acs.biomac.1c00553, 2021.06.
9. 長尾 匡憲、松原 輝彦、星野 友、佐藤 智典、三浦 佳子, Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus, Biomacromolecules, 10.1021/acs.biomac.9b00515, 20, 7, 2763-2769, 2019.06, Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin–spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target..
10. 長尾 匡憲、松原 輝彦、星野 友、佐藤 智典、三浦 佳子, Topological Design of Star Glycopolymers for Controlling the Interaction with the Influenza Virus, Bioconjugate Chemistry, org/10.1021/acs.bioconjchem.9b00134, 30, 4, 1192-1198, 2019.03, The precise design of synthetic polymer ligands using controlled polymerization techniques provides an advantage for the field of nanoscience. We report the topological design of glyco-ligands based on synthetic polymers for targeting hemagglutinin (HA, lectin on the influenza virus). To achieve precise arrangement of the glycounits toward the sugar-binding pockets of HA, triarm star glycopolymers were synthesized. The interaction of the star glycopolymers with HA was found to depend on the length of the polymer arms and was maximized when the hydrodynamic diameter of the star glycopolymer was comparable to the distance between the sugar-binding pockets of HA. Following the formula of multivalent interaction, the number of binding sites in the interaction of the glycopolymers with HA was estimated as 1.8–2.7. Considering one HA molecule has three sugar-binding pockets, these values were reasonable. The binding mode of synthetic glycopolymer–ligands toward lectins could be tuned using controlled radical polymerization techniques..
11. 長尾 匡憲、星野 友、三浦 佳子, Quantitative preparation of multiblock glycopolymers bearing glycounits at the terminal segments by aqueous reversible addition–fragmentation chain transfer polymerization of acrylamide monomers, Journal of Polymer Science Part A: Polymer Chemistry, 10.1002/pola.29344, 57, 8, 857-861, 2019.03, Multiblock glycopolymers have gathered attention because of their potential use as effective ligands for sugar‐binding proteins. The authors report the quantitative preparation of multiblock glycopolymers by reversible addition‐fragmentation chain transfer polymerization. The optimized polymerization condition enabled the complete monomer incorporation into the elongating polymer chains at each polymerization step. The structure of the heptablock glycopolymer was well‐defined (polydispersity index
12. 長尾 匡憲、Jayeeta Sengupta、Diana Diaz-Dussan、Madeleine Adam、@Meng Wu、@Jason Acker、@Robert Ben、@石原 一彦、@Hongbo Zeng、三浦 佳子、@Ravin Narain, Synthesis of Highly Biocompatible and Temperature-Responsive PhysicalGels for Cryopreservation and 3D Cell Culture, ACS Appl Bio Mat, doi.org/10.1021/acsabm.8b00096, 1, 2, 356-366, 2018.06, There is considerable interest in the cryopreservation in 3D cell culture, as structurally preserving intact cells and tissues is critical in utilizing these systems to promote cell differentiation and tissue organization. Temperature-responsive physical gels and zwitterionic polymers are useful materials as 3D scaffolds for cell culture which may also provide cryoprotection to the composite cells. Nevertheless, there has been a lack of relevant data for polymer systems that have both of these properties. In this study, highly biocompatible triblock copolymers were examined for their effectiveness both as gelators and as cryo-protectants. The triblock copolymers were synthesized with 2-methacryloyloxyethyl phosphorylcholine (MPC) and di(ethylene glycol) methyl ether methacrylate (DEGMA) via atom transfer radical polymerization (PDEGMA113-b-PMPC243-b-PDEGMA113). ABA triblock copolymers composed of hydrophilic “B” block and temperature responsive “A” block could form physical gels above their lower critical solution temperatures (LCST). PDEGMA113-b-PMPC243-b-PDEGMA113 triblock copolymer exhibited the LCST derived from DEGMA and assembled in micellar structures forming physical gels above the LCST. The mechanical properties of the physical gels were evaluated by rheological tests, and the low toxicity of PDEGMA113-b-PMPC243-b-PDEGMA113 was confirmed by MTT assay. Interestingly, the triblock copolymer showed ice recrystallization inhibition (IRI) activity which was determined to be suitable for the cryopreservation of several cell lines. In vitro studies were conducted to demonstrate the cryo-protectant properties and the formation of two and three-dimensional (2D/3D) cell culture scaffolds with high biocompatibility. This stimuli-responsive gelator polymers can therefore be useful for cryopreservation of different cells models, and a promising material for 3D cell culture..
13. 長尾 匡憲、松原 輝彦、星野 友、佐藤 智典、三浦 佳子, Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus, Biomacromolecules, 10.1021/acs.biomac.7b01426, 18, 12, 4385-4392, 2017.11, We designed glycopolymers carrying sialyl oligosaccharides by “post-click” chemistry and evaluated the interaction with the influenza virus. The glycopolymer structures were synthesized in a well-controlled manner by reversible addition–fragmentation chain transfer polymerization and the Huisgen reaction. Acrylamide-type monomers were copolymerized to give hydrophilicity to the polymer backbones, and the hydrophilicity enabled the successful introduction of the oligosaccharides into the polymer backbones. The glycopolymers with different sugar densities and polymer lengths were designed for the interaction with hemagglutinin on the virus surface. The synthesized glycopolymers showed the specific molecular recognition against different types of influenza viruses depending on the sugar units (6′- or 3′-sialyllactose). The sugar density and the polymer length of the glycopolymers affected the interaction with the influenza virus. Inhibitory activity of the glycopolymer against virus infection was demonstrated..
14. 長尾 匡憲、@紅林 佑希、瀬戸 弘一、@高橋 知成、@鈴木 隆、星野 友、三浦 佳子, Polyacrylamide backbones for polyvalent bioconjugates using “post-click” chemistry, Polymer Chemistry, doi.org/10.1039/C6PY00904B, 7, 5920-5924, 2016.07, This paper reports the synthesis and application of acrylamide-type neoglycoconjugates interacting with practical targets. Polymer backbones with acrylamide and acrylamide derivatives bearing alkyne groups were prepared using living radical polymerization. Oligosaccharides were introduced into the backbones using copper-catalysed azide–alkyne cycloaddition “post-click” chemistry..
15. 長尾 匡憲、@紅林 佑希、瀬戸 弘一、@田中 知成、@高橋 忠伸、@鈴木 隆、星野 友、三浦 佳子, Synthesis of well-controlled glycopolymers bearing oligosaccharides andtheir interactions with influenza viruses, Polymer Journal, doi.org/10.1038/pj.2016.14, 48, 6, 745-749, 2016.02, Glycopolymers bearing oligosaccharides with narrow polydispersity indexes (
主要総説, 論評, 解説, 書評, 報告書等
1. 長尾匡憲, 松本光, 三浦佳子, Design of Glycopolymers for Controlling the Interactions with Lectins, Chemistry—An Asian Journal, 10.1002/asia.202300643, 2023.08.
主要学会発表等
1. 長尾匡憲, Precise Design of Star Polymers for Controlling the Interactions with the Target Biomolecules, 日本化学会 第104春季年会, 2024.04.
2. 長尾匡憲、堀江彩、三浦佳子, Continuous flow photoinduced polymerization in a packed bed reactor
, The 2023 Joint Symposium on Green Chemistry and Clean Technology, 2023.11.
3. 長尾匡憲、三浦佳子, Topological Design of Star Glycopolymers for Controlling the Interactions with the Influenza virus, Canadian Chemical Engineering Conference (CSChE 2023), 2023.10.
4. 長尾匡憲, 吉松大地, 三浦佳子, 両親媒性高分子の水中での自己収縮に伴う運動性の制御と分子認識, 第72回 高分子討論会 , 2023.09.
5. 長尾匡憲, 吉松大地, 三浦佳子, 水中における両親媒性合成高分子の自己収縮と分子認識, 第33回 バイオ・高分子シンポジウム , 2023.07.
6. 長尾匡憲, 三浦佳子, Correlation between percent collapse of self-folding amphiphilic polymers and their molecular flexibility, 第72回 高分子年次大会, 2023.05.
7. 長尾匡憲, Topological design of synthetic polymers for controlling the biomolecular recognition, 第72回 高分子年次大会, 2023.05.
8. 長尾匡憲, 山口愛, 松原輝彦, 星野友, 佐藤智典, 三浦佳子, 最適に設計された分子形状や大きさによって標的タンパク質に結合する合成糖鎖高分子リガンド, 第71回 高分子討論会 , 2022.09.
9. 長尾匡憲, 松原輝彦, 星野友, 佐藤智典, 三浦佳子, 生体分子を標的とした合成高分子リガンドのトポロジー設計, 第32回 バイオ・高分子シンポジウム , 2022.07.
10. 長尾匡憲, 吉瀬誠也, 星野友, 三浦佳子, 糖鎖高分子の側鎖の構造が標的タンパク質との相互作用に与える影響, 第71回 高分子年次大会, 2022.05.
11. 長尾匡憲, 松原輝彦, 星野友, 佐藤智典, 三浦佳子 , インフルエンザウイルスと結合する糖鎖高分子の構造設計, 第40回 糖質学会年会, 2021.10.
12. 長尾匡憲, 松原輝彦, 星野友, 佐藤智典, 三浦佳子, インフルエンザウイルスに対する星型糖鎖高分子の構造設計, 第70回 高分子討論会, 2021.09.
13. 長尾匡憲, 松原輝彦, 星野友, 佐藤智典, 三浦佳子, インフルエンザウイルスに対する合成糖鎖高分子リガンドの幾何学形状設計, 第31回 バイオ・高分子シンポジウム, 2021.06.
特許出願・取得
特許出願件数  1件
特許登録件数  0件
学会活動
所属学会名
化学工学会
高分子学会
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2022年度
受賞
若手研究者奨励講演賞, 公益社団法人 高分子学会 バイオ・高分子研究会, 2022.07.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2022年度~2025年度, 学術変革領域研究(B), 分担, 精密高分子の合成.
2022年度~2023年度, 学術変革領域研究(A), 代表, 膜タンパク質を模倣した精密合成高分子による集積応答型膜システムの構築.
2022年度~2023年度, 若手研究, 代表, 環状トポロジーの導入により標的への結合力を高めた生体模倣高分子の精密設計.
寄附金の受入状況
2024年度, 公益財団法人 岩谷科学技術財団, 第50回 岩谷科学技術財団研究助成 / 高分子による反応場を利用した高効率なCO2光還元触媒の開発.
2023年度, 公益財団法人 池谷科学技術振興財団, 2023年度 池谷科学技術振興財団研究助成 / タンパク質を模倣したフォールディング挙動により標的と強く結合する合成高分子の開発.
2022年度, 公益財団法人 戸部眞紀財団, 2022年度 戸部眞紀財団研究助成金 / ポルフィリンによる効率的なCO2光還元に向けたゲル内反応場の設計.
2022年度, 公益財団法人 旭硝子財団, 2022年度 旭硝子財団研究助成金/
不凍タンパク質の代替材料開発に向けた糖鎖高分子ライブラリーの合成と解析.
学内資金・基金等への採択状況
2022年度~2023年度, 令和4年度 工学研究新分野開拓助成, 代表, ポルフィリンによるCO2 光還元反応の制御を目指した高分子反応場の設計.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。