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List of Papers
Yoshida Yuya Last modified date：2024.04.09

Assistant Professor / Department of Clinical Pharmacokinetics / Department of Pharmaceutical Health Care and Sciences / Faculty of Pharmaceutical Sciences


Papers
1. Yuya Yoshida, Taiki Fukuda, Kohei Fukuoka, Toshitaka Nagayama, Tomohito Tanihara, Naoki Nishikawa, Kaita Otsuki, Yuma Terada, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Kota Mayanagi, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo, Time-dependent differences in vancomycin sensitivity of macrophages underlie vancomycin-induced acute kidney injury, Journal of Pharmacology and Experimental Therapeutics, 10.1124/jpet.123.001864, JPET-AR, 2023.11.
2. Daiki Yamane, Ryo Tetsukawa, Naoki Zenmyo, Kaori Tabata, Yuya Yoshida, Naoya Matsunaga, Naoya Shindo, Akio Ojida, Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines., Journal of medicinal chemistry, 10.1021/acs.jmedchem.3c00737, 66, 13, 9130-9146, 2023.07.
3. Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, Toru Takeo, Naomi Nakagata, Shigekazu Higuchi, Yukihiko Sugimoto, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo, Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior., International journal of molecular sciences, 10.3390/ijms25031841, 25, 3, 2024.02.
4. Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, Taisei Kumamoto, Kosuke Oyama, Takashi Ogino, Akito Tsuruta, Kouta Mayanagi, Tomohiro Yamashita, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu, Hitomi Kawakami, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo, Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment., Translational research : the journal of laboratory and clinical medicine, 10.1016/j.trsl.2024.02.004, 2024.02, Chronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppressing GPR68 function. Reagents that inhibit the function of GPR68 were explored by high-throughput screening using a medicinal plant extract library (8,008 species), and we identified an extract from Cephalotaxus harringtonia var. nana as a GPR68 inhibitor that suppresses inflammatory cytokine production in a GPR68 expression-dependent manner. Consumption of the extract inhibited inflammatory cytokine expression and cardiac fibrosis and improved the decreased survival attributable to 5/6Nx. Additionally, homoharringtonine, a cephalotaxane compound characteristic of C. harringtonia, inhibited inflammatory cytokine production. Homoharringtonine administration in drinking water alleviated cardiac fibrosis and improved heart failure and survival in 5/6Nx mice. A previously unknown effect of C. harringtonia extract and homoharringtonine was revealed in which GPR68-dependent inflammation and cardiac dysfunction were suppressed. Utilizing these compounds could represent a new strategy for treating GPR68-associated diseases, including CKD..
5. Kengo Hamamura, Yuya Yoshida, Kosuke Oyama, Junhao Li, Shimpei Kawano, Kimiko Inoue, Keiko Toyooka, Misaki Yamadera, Naoya Matsunaga, Tsuyoshi Matsumura, Kosuke Aritake, Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy., International journal of molecular sciences, 10.3390/ijms25031846, 25, 3, 2024.02.
6. Yuya Yoshida, Taiki Fukuda, Tomohito Tanihara, Naoki Nishikawa, Serina Iwasa, Satoka Adachi, Orion Zaitsu, Yuma Terada, Ryotaro Tsukamoto, Hideki Shimoshikiryo, Kohei Fukuoka, Fumiaki Tsurusaki, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo, Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer, Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2024.149813, 708, 149813-149813, 2024.05.
7. Yoshida Y, Fukuda T, Fukuoka K, Nagayama T, Tanihara T, Nishikawa N, Otsuki K, Terada Y, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S., Time-Dependent Differences in Vancomycin Sensitivity of Macrophages Underlie Vancomycin-Induced Acute Kidney Injury., J Pharmacol Exp Ther. , 2024.01.
8. Kohei Fukuoka, Yuya Yoshida, Kurumi Sotono, Naoki Nishikawa, Kengo Hamamura, Kosuke Oyama, Akito Tsuruta, Kota Mayanagi, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo, Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease, Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2023.07.015, 675, 92-98, 2023.10.
9. Akito Tsuruta, Daiki Kanetani, Yuki Shiiba, Takuto Inoki, Yuya Yoshida, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins, Biochemical Pharmacology, 10.1016/j.bcp.2023.115708, 215, 115708-115708, 2023.09.
10. Shohei Uchinomiya, Tomoki Nagaura, Mark Weber, Yuya Matsuo, Naoki Zenmyo, Yuya Yoshida, Akito Tsuruta, Satoru Koyanagi, Shigehiro Ohdo, Naoya Matsunaga, Akio Ojida, Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes, Journal of the American Chemical Society, 10.1021/jacs.3c02043, 145, 14, 8248-8260, 2023.04.
11. Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, Jose M. M. Caaveiro, Yuya Yoshida, Shigehiro Ohdo, Naoya Matsunaga, Shinsuke Toba, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Eiji Kawanishi, Akio Ojida, Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease, Journal of Medicinal Chemistry, 10.1021/acs.jmedchem.2c01081, 65, 20, 13852-13865, 2022.10, [URL].
12. Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi, Shigehiro Ohdo, Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis, Nature Communications, 10.1038/s41467-021-23050-x, 12, 1, 2021.05.
13. Akito Tsuruta, Yuki Shiiba, Naoya Matsunaga, Marina Fujimoto, Yuya Yoshida, Satoru Koyanagi, Shigehiro Ohdo, Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice., Molecular cancer research : MCR, 10.1158/1541-7786.MCR-21-0786, 20, 6, 972-982, 20(6):972-982, 2022.06.
14. Naoya Matsunaga, Yuya Yoshida, Naoki Kitajou, Akira Shiraishi, Naoki Kusunose, Satoru Koyanagi, Shigehiro Ohdo, Microcurrent stimulation activates the circadian machinery in mice, Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2019.02.022, 513, 2, 293-299, 2019.05.
15. Kengo Hamamura, Naoya Matsunaga, Eriko Ikeda, Hideaki Kondo, Hisako Ikeyama, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Yuya Yoshida, Masaki Matsuda, Kaori Yasuda, Atsushi Doi, Yoshifumi Yokota, Toshiaki Amamoto, Hironori Aramaki, Yasuhiro Irino, Satoru Koyanagi, Shigehiro Ohdo, Alterations of hepatic metabolism in chronic kidney disease via D-box-binding protein aggravate the renal dysfunction, Journal of Biological Chemistry, 10.1074/jbc.M115.696930, 291, 10, 4913-4927, 2016.03.
16. Naoya Matsunaga, Eriko Ikeda, Keisuke Kakimoto, Miyako Watanabe, Naoya Shindo, Akito Tsuruta, Hisako Ikeyama, Kengo Hamamura, Kazuhiro Higashi, Tomohiro Yamashita, Hideaki Kondo, Yuya Yoshida, Masaki Matsuda, Takashi Ogino, Kazutaka Tokushige, Kazufumi Itcho, Yoko Furuichi, Takaharu Nakao, Kaori Yasuda, Atsushi Doi, Toshiaki Amamoto, Hironori Aramaki, Makoto Tsuda, Kazuhide Inoue, Akio Ojida, Satoru Koyanagi, Shigehiro Ohdo, Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease, EBioMedicine, 10.1016/j.ebiom.2016.10.008, 13, 262-273, 2016.11.
17. Naoki Kusunose, Akito Tsuruta, Kengo Hamamura, Yuya Tsurudome, Yuya Yoshida, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches, Genes to Cells, 10.1111/gtc.12758, 25, 4, 270-278, 2020.04.


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